Abstract: Exemplary embodiments of the present invention relate to a complex formulation for treating adipositas or improving a therapeutic effect, and more particularly, to a complex formulation prepared by including colchicine and metformin as main effective agents. According to exemplary embodiments of the present invention, the composition may be used as an excellent pharmaceutical composition capable of preventing or treating obesity by efficiently decomposing fat accumulated in the body by a synergic effect of colchicine and metformin.

Abstract: The present invention relates to a composition for preventing or treating liver diseases, and more particularly, provides a pharmaceutical composition for preventing or treating liver diseases containing colchicine and a dipeptidyl peptidase-4 (DPP-4) inhibitor as active ingredients. The pharmaceutical composition according to the present invention may significantly reduce liver injury such as fibrosis, fat accumulation, and inflammation in hepatocytes or liver tissues and more effectively prevent or treat liver diseases by co-using colchicine and a DPP-4 inhibitor, which are drugs used for treating other diseases in the related art.

Abstract: The present invention relates to a pharmaceutical composition comprising an antagonist of the phosphorylation of HMGB1, and a method for treating a condition associated with activation of the inflammatory cytokine cascade comprising administering an effective amount of an said antagonist of HMGB1 phosphorylation.