Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15R? Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

Abstract: The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.

Abstract: A vessel for cooling drinks includes external walls and inner walls that can be joined together to define internal housings to house drinks containers. The walls contain a volume of eutectic liquid, which absorbs heat and cools the drink by contact through the walls.

Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15R? Fc fusion protein and an NKG2D antigen binding domain Fc fusion proteins.

Abstract: An article of footwear includes an injection molded outsole of a first material having a durometer reading of at least 28 to at most 38 on the Asker C scale, an injection molded insole of a second material having a durometer reading of at least 28 to at most 38 on the Asker C scale, and an upper, at least a section of a peripheral edge of the upper being sandwiched between the insole and the outsole.

Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15R? Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.

Abstract: The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes engineered protease site for cleavage antigen-antibody or antigen-polypeptide complexes. In some embodiments the protease cleavage site to cleave the complexes is an exogenous protease to mammalian cell. In various embodiments the protease cleavage site to cleave the complexes is an endogenous protease to mammalian cell.

Abstract: A method and system for intelligent demand response by a load controller device connected to a load is provided. Demand response events generated by utilities can generate energy conservation however they can provide demand subpeaks during the event and can impact user comfort. In order to improve the energy profile and user comfort one or more event parameters from the DR event are generated. One or more temperature setpoints of the load controller device are modified to provide smooth setpoint transition between temperature setpoints using the generated one or more event parameters to shape electricity demand of the load to reduce an expected demand subpeak during the DR event. The modified one or more temperature setpoints can be applied at an associated time to control the load.

Abstract: The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes engineered protease site for cleavage antigen-antibody or antigen-polypeptide complexes. In some embodiments the protease cleavage site to cleave the complexes is an exogenous protease to mammalian cell. In various embodiments the protease cleavage site to cleave the complexes is an endogenous protease to mammalian cell.

Abstract: A method and system for intelligent demand response by a load controller device connected to a load is provided. Demand response events generated by utilities can generate energy conservation however they can provide demand subpeaks during the event and can impact user comfort. In order to improve the energy profile and user comfort one or more event parameters from the DR event are generated. One or more temperature setpoints of the load controller device are modified to provide smooth setpoint transition between temperature setpoints using the generated one or more event parameters to shape electricity demand of the load to reduce an expected demand subpeak during the DR event. The modified one or more temperature setpoints can be applied at an associated time to control the load.

Abstract: A method of using BIOS information can include exporting first BIOS information from a first information handling system. The method can further include initiating a boot sequence for the second information handling system and importing second BIOS information into a second information handling system after initiating the boot sequence and before initiating an operating system, wherein the second BIOS information is associated with the first BIOS information. The method can further include initiating an operating system of the second information handling system after importing the second BIOS information. The first and second BIOS information may be the same, or the second BIOS information may be derived from the first BIOS information. The first and second information handling systems may be the same or different. In one embodiment, the first BIOS information can be translated into a text file for editing before using the second BIOS information during a boot sequence.

Abstract: Methods and systems are provided for recovering configuration data in a computer system. According to one method, a device is selected as a current device. A first map location is retrieved from a layout of present configuration data stored in a computer system. Next, a second map location is retrieved from a layout of updated configuration data stored in the computer system for the current device. A determination is then made as to whether the first map location matches the second map location for the current device. If it is determined that the first map location matches the second map location for the current device, then the next hardware device in the set of devices is selected as the current device.

Abstract: A method of using BIOS information can include exporting first BIOS information from a first information handling system. The method can further include initiating a boot sequence for the second information handling system and importing second BIOS information into a second information handling system after initiating the boot sequence and before initiating an operating system, wherein the second BIOS information is associated with the first BIOS information. The method can further include initiating an operating system of the second information handling system after importing the second BIOS information. The first and second BIOS information may be the same, or the second BIOS information may be derived from the first BIOS information. The first and second information handling systems may be the same or different. In one embodiment, the first BIOS information can be translated into a text file for editing before using the second BIOS information during a boot sequence.

Abstract: A method and computer system are provided for recovering program code in a memory device. A determination is made as to whether current program code stored in a memory device in the computer system is valid. The current program code may be current BIOS code for the computer system. If it is determined that the current program code is invalid, code stored in the memory device is executed to copy an image file from a storage device to a main memory in the computer system. The image file includes recovery program code for the memory device. The current program code in the memory device is then updated with the recovery program code from the main memory. Prior to updating the current program code, a flag is set indicating that the current program code needs to be updated. A boot of the computer system is then initiated from the image file and upon detecting the flag, the boot of the computer system is interrupted.

Abstract: The invention relates to tetrahydroisoquinoline sulfonamide compounds (of formula (1) as defined in the specification), their preparation and their use in therapies for the treatment of central nervous system diseases such as vigilance and sleep disorders, narcolepsy, Alzheimer's disease and other dementias, Parkinson's disease, attention disorders in hyperkinetic children, memory and learning disorders, epilepsy, schizophrenia, moderate cognitive disorders, depression, anxiety, sexual dysfunction, dizziness and travel sickness.

Abstract: A system and method is disclosed for the handling of interrupts by the disabled logical processors of an information handling system or computer system. An interrupt service routine is written to the read-only portion of system memory. Upon receipt of an interrupt, each disabled logical processor branches to the hard coded interrupt service routine. The interrupt service routine can be written to read only memory because the context, current instruction, and return state of the disabled logical processor are known, and the disabled logical processor will not need to write to system memory during the execution of the interrupt service routine. Following the handling of the interrupt by another logical processor of the computer system, each disabled logical processor returns to the halt state.

Abstract: A computer program product is provided that is readable by a computing system and encoding a computer program of instructions. The computer program product includes a hardware protected region that is utilized to store a portion of a computer BIOS. The BIOS includes a compressed computer program for restoring at least a portion of the computer BIOS when uncompressed and executed. The computer program product also includes a non-hardware protected region that is utilized to store the remainder of the computer BIOS. The hardware protected region may include an uncompressed computer program that may be utilized to uncompress the compressed program. The hardware protected region may also include an uncompressed program for detecting and initializing one or more memory devices within the computer system. Methods and apparatus are also provided for creating and utilizing the contents of the computer program product.

Abstract: Methods are provided for detecting the validity of configuration data and recovering configuration data in a computer system. A layout of present configuration data is detected in the computer system. The present configuration data is stored in a memory device which may be a non-volatile random access memory (“NVRAM”) device. Next, a layout of updated configuration data for the computer system is detected. The updated configuration data is stored within program code, such as a BIOS, which includes an updated configuration for the computer system. Next, the layout of the present configuration data is compared to the layout of the updated configuration data in the computer system. If the layout of the present configuration data matches the layout of the updated configuration data, then it is determined that the present configuration data is valid configuration data for the computer system.