Abstract: A delivery system including a distal capture device that has a sleeve with a passageway defined axially therethrough and one or more elastically deformable sections. Each of the one or more elastically deformable sections has a free terminating end and an opposite end mounted to the distal end of the sleeve. The elastically deformable sections transition between: (i) a fully expanded state in which the elastically deformable section is distally biased in a direction away from the sleeve; and (ii) a retracted state in which the free terminating end of each of the elastically deformable sections is proximally deflected backwards over itself in a direction toward the proximal end of the sleeve.

Abstract: An occlusion device for treating an aneurysm can have an inner embolic device with a proximal section and a distal section. The distal section has a first stiffness and the proximal section has a second stiffness. Further, the device has an expandable mesh capable of a collapsed position and an expanded position. The mesh can be disposed over, and attached to, a portion of the proximal section of the inner embolic device. The first stiffness is greater than the second stiffness and the inner embolic device comprises a preselected shape which assists in transforming the expandable mesh from the collapsed position to the expanded position.

Abstract: A detachment actuator for use with an implantable medical device deployment system that guide and deploys the medical device at a target location within a body vessel. The detachment actuator includes a first portion that is connected the implantable medical device and a second portion that is attached to a control member the controls the release of the medical device, The second portion of the detachment actuator detaches and moves away from the first portion of the detachment actuator to move the control member and release the medical device.

Abstract: A vasculature occlusion device detachment system including a heating fuse element made of a material that melts when a current is applied that exceeds a predetermined maximum current threshold. An electrically conductive corewire connected proximate its distal end directly to the heating fuse element at a first electrical connection joint, while a separate insulated electrically conductive wire is electrically connected directly to the heating fuse element at a second electrical connection joint. An inner insulation sleeve placed over a distal section of the corewire covers the first electrical connection joint and is disposed between the insulated electrically conductive wire and the electrically conductive corewire. An outer insulation sleeve is disposed over a distal section of an assembly including the insulated electrically conductive wire, the inner insulation sleeve and the electrically conductive corewire. The outer insulation sleeve covers the second electrical connection joint.

Abstract: A vasculature occlusion device detachment system including a heating element of a predetermined resistivity. A coil securing suture terminates in a proximal bead retained within the heating element while the distal end of the coil securing suture extends beyond the distal end of the heating element and is attached to the proximal end of the vasculature occlusion device. The coil securing suture is independently rotatable of the heating element 360 degrees about a longitudinal axis extending therethrough the heating element. A power source applies electrical current to the heating element via an electrically conductive corewire and separate insulated electrically conductive wire to increase its resistance and, as a result of the heat produced, sever the coil securing suture.

Abstract: A mechanism can include a step feature guidewire having a guidewire with a proximal end, a distal end, and a diameter. A self-expanding element can be disposed approximate to the distal end of the guidewire and can have at least two states which include a contracted diameter and an expanded diameter. The self-expanding element can be expandable under its inherent proprieties, based at least on its original shape and the nature of the materials that make up the element. Further, the expanded diameter can be approximately 70% to 280% of the guidewire diameter. While the guidewire is designed for passing through a body lumen while treating a patient, the expanded diameter is less than any body lumen diameter the guidewire is determined to pass through.

Abstract: An embolic device deployment system includes a catheter having a first lumen and proximal and distal ends. A notch is disposed in the first lumen, forming a second lumen. An embolic device has a retaining ring at the proximal end. An engagement member includes a distal loop extending through the retaining ring, and a proximal loop extending into the first lumen. An elongated detachment member can be disposed through the loops and have a detachment member bump disposed between the loops. When the detachment member is disposed within the distal loop and the distal loop is disposed within the retaining ring, the embolic device is engaged. When the detachment member is pulled proximally, the detachment member is withdrawn from the distal loop, and the detachment member bump contacts the proximal loop. These acts assist in the disengagement of the distal loop from the retaining ring to release the embolic device.

Abstract: A vascular occlusion device for effectively occluding blood flow and pressure to a vascular defect while simultaneously not occluding blood flow and pressure to adjacent vasculature is provided. The vascular occlusion device can include a tubular member that has variable porosity regions along its length. The tubular member can be formed of a plurality of filaments that have different cross-sectional shapes along their length that are indexed to the variable porosity regions along the length of the tubular member.

Abstract: Provided herein are a system, method, and apparatus for delivering a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. A heating element is disposed in the delivery tube that can be actuated remotely, and a layer of low temperature adhesive is applied at the heating element to retain the therapeutic device. The kicker in the form of, for example, a compressed spring is mounted within the delivery tube so as to be in contact with the therapeutic device for applying a constant ejector force that is countered by the adhesive force of the low temperature adhesive. When the heating element is actuated, the spring's ejector force overcomes the softened adhesive's adhesive force to force the therapeutic device out of the delivery tube.

Abstract: A stretch-resistant occlusive device, and method of manufacturing such a device, having a helically wound coil defining a coil lumen extending along the entire axial length of the coil from a proximal end portion to a distal end portion. The device further includes a headpiece having a proximal end, a distal end attached to the proximal end portion of the coil, and a headpiece lumen extending between the proximal and distal ends of the headpiece. An anchor filament extends through the headpiece lumen, has at least one proximal end secured to the proximal end of the headpiece, and has a distal portion defining an eye positioned distal to the distal end of the headpiece. A stretch resistant member is positioned within the coil lumen, has a proximal portion extending through the eye, and has at least one distal end secured to the distal end of the coil.

Abstract: A generally tubular braided flow diverting stent is formed of alternating round and rectangular elongated members, for treatment of aneurysms. The generally tubular braided flow diverting stent maintains a significant wall thickness while increasing area coverage of a vessel wall. Sliding of the round elongated members over the rectangular elongated members allows the stent to be crimped to very low diameters for delivery in narrow portions of the vasculature.

Abstract: Provided herein are a system, method, and apparatus for delivering a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. A heating element is disposed in the delivery tube that can be actuated remotely, and a layer of low temperature adhesive is applied at the heating element to retain the therapeutic device. The kicker in the form of, for example, a compressed spring is mounted within the delivery tube so as to be in contact with the therapeutic device for applying a constant ejector force that is countered by the adhesive force of the low temperature adhesive. When the heating element is actuated, the spring's ejector force overcomes the softened adhesive's adhesive force to force the therapeutic device out of the delivery tube.

Abstract: A delivery system for an embolic coil including a delivery tube having a lumen. A proximal coil junction is disposed between the delivery tube and the embolic coil. Insertable through the lumen and extending proximally beyond the proximal end of the delivery tube is a detachable wire with a terminating feature disposed on its distal end. At least one stretch resistant member is disposed within a lumen formed by the embolic coil. A distal end of each of the at least one stretch resistant members is secured to a distal end of the embolic coil, while each of the at least one stretch resistant members is also secured proximate the proximal end of the embolic coil. The distal end of the delivery tube is retained by the wire physically against without being attached in any way to the proximal junction.

Abstract: An occlusion device suitable for endovascular treatment of an aneurysm in a blood vessel in a patient, including a substantially tubular structure having a proximal end region and a distal end region, having a first, expanded condition and a second, collapsed condition. The device has dimensions in the second, collapsed condition suitable for insertion through vasculature of the patient and through a neck of the aneurysm. The device further includes a control ring having a substantially annular body disposed on the proximal end region of the structure and at least substantially circumscribing the proximal end region to prevent radial expansion of the proximal end region and to provide an engagement feature during manipulation of the occlusion device.

Abstract: An expansion ring for a braided stent includes a plurality of elongated forked frame elements forming the expansion ring. Each of the frame elements includes first and second legs extending in one direction and connected together at a junction portion forming a fulcrum allowing compression of the frame elements, and each of the frame elements are threaded through interstices in a tubular body of the braided stent so that the junction portions engage the tubular body of the braided stent. Each of the frame elements is connected sequentially to adjacent frame elements at the ends of the first and second legs, and the expansion ring has a compressed configuration with a first diameter and an expanded configuration with a second diameter larger than the first diameter.

Abstract: Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a series of connectors. The series of connectors include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, is disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the bead and therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

Abstract: An embolic coil detachment system includes an elongated, flexible polymer tube having a tubular wall with an inner surface defining an interior lumen. A distal portion of the tubular wall has a score line, and a resistive heating element is located near the score line and in immediate contact with a surface of a distal portion of the tubular wall, to provide direct heating of the distal portion of the flexible polymer tube adjacent to the score line. A therapeutic embolic coil includes a headpiece that is releasably attached within the distal portion of the flexible polymer tube, and that is releasable by heating of the distal portion of the tubular shaft to cause the distal portion of the tubular wall to split along the score line.

Abstract: The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo[2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders.

Abstract: A system for delivering and releasing a self-expanding stent includes a catheter, a tubular self-expanding stent configured to be constrained from expanding when the tubular self-expanding stent is contained within the catheter, and a core advancement wire disposed within and extending through a lumen of the tubular self-expanding stent. One or more stop members on the core advancement wire engage one or more anchor members on the stent when the core advancement wire is translated longitudinally toward the one or more anchor members.

Abstract: A capture tube mechanism for delivering and releasing a self-expanding stent includes a core wire on which a proximal portion of the stent is removably retained by a distal portion of a tubular capture sleeve. In one embodiment, one or more elongated members extending through corresponding apertures through the capture sleeve and out the distal end of the capture sleeve can be pulled to split the tubular capture sleeve to release the stent. In another embodiment, the capture sleeve can be pulled proximally over one or more stop members provided on the core wire to release the stent.