Abstract: Systems and methods are directed to a pull-through winding method, and a manufacturing fixture, or mandrel, that guides the layup of material in the pull-through winding method, for fabrication of a three-dimensional load bearing structure. These systems and methods allow fibers of material of the 3D load bearing structure to be pulled as straight as possible during winding, and maintained as straight as possible during curing, to take full advantage of properties associated with the fiber or filament-based materials used in these structures, including, for example, carbon fiber material. The manufacturing fixture includes a plurality of pull-through slots at end portions thereof, that provide for the pulling of the fiber-based material, and the application and maintenance of tension in the material that maintains the alignment of the fibers as the material is wound, cured and hardened.

Abstract: The present invention relates to a pallet with impact resistant columns (3) comprising a structure for the distribution of impact energy (4) configured for the distribution of impact forces, at the same time as its internal structure deforms and is compacted upon receiving impacts, such that the pallet remains functional although its columns (3) are permanently deformed and/or partially fractured.

Abstract: The present invention relates to a pallet with impact resistant columns (3) comprising a structure for the distribution of impact energy (4) configured for the distribution of impact forces, at the same time as its internal structure deforms and is compacted upon receiving impacts, such that the pallet remains functional although its columns (3) are permanently deformed and/or partially fractured.

Abstract: The present invention provides formulations for enhancing bioavailability of water-soluble compounds including water-soluble vitamins. The formulations include a water-soluble vitamin and a glycoside selected from a diterpene glycoside and a triterpene glycoside.

Abstract: Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRC1) wherein the 5? region of the nucleotide sequence encoding MRC1 is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody production, e.g., neutralizing antibody production, in a subject being treated for Gaucher disease using such cells.

Abstract: The present invention provides formulations for enhancing bioavailability of watersoluble compounds including water-soluble vitamins. The formulations include a watersoluble vitamin and a glycoside selected from a diterpene glycoside and a triterpene glycoside. Methods for increasing the bioavailability of a water-soluble vitamin are also described.

Abstract: Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Abstract: The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.

Abstract: Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Abstract: Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS). The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Abstract: The present invention relates to the use of cardiotrophin-1 (CT-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1.

Abstract: Methods and kits for determining the presence in a patient biological sample of an antibody which binds to an agent (e.g., an enzyme administered in the course of ERT), and optionally determining the neutralizing effect or lack thereof of the antibody on the agent are disclosed.

Abstract: Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRC1) wherein the 5? region of the nucleotide sequence encoding MRC1 is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody production, e.g., neutralizing antibody production, in a subject being treated for Gaucher disease using such cells.

Abstract: Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Abstract: The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.

Abstract: A technique for handling hardware errors in a computing system, such as a data storage facility, while avoiding a system crash. An interface is registered with an operating system of the computing system to process hardware errors. When a hardware error is detected, the interface checks an error register to identify the adapter that likely causes the error, and quarantines, e.g., blocks off, the offending adapter from the computing system. The interface then notifies the operating system that the error has been handled, thereby causing the operating system to bypass a system crash that would otherwise occur. The interface can be provided as a kernel extension of a device driver associated with the operating system.

Abstract: According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1.2 in bodily fluids that also contain prothrombin or other plasma proteins. Antibodies having the necessary properties for this assay are made using synthetic polypeptides which mimic the carboxy terminus of F1.2.

Abstract: According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1.2 in bodily fluids that also contain prothrombin or other plasma proteins. Antibodies having the necessary properties for this assay are made using synthetic polypeptides which mimic the carboxy terminus of F1.2.