Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.

Abstract: A peptide sequence of a guide protein for the production of a peptide of interest; a peptide sequence that has a similarity of at least 90% to SEQ. ID. NO 1; a nucleotide sequence encoding the guide protein; an expression vector comprising the nucleotide sequence; a host cell that expresses a fusion protein comprising a peptide of interest; a method of production of a peptide of interest, comprising the steps of A) constructing an expression vector; B) inserting the expression vector into a host cell; C) expressing the fusion protein, culturing the host cell in a culture medium; D) recovering the accumulated fusion protein in the host cell; E) cleaving the fusion protein; F) purifying the peptide of interest.

Abstract: There is disclosed a wearable, personal safety device that can be activated to silently send an alarm along with a video and an audio feed, in real time, to a monitoring authority. The personal safety device includes a support member for positioning the personal safety device on a user and housing affixed to the support member and containing a main circuit board and a camera system connected to the main circuit board. The camera system includes both video and audio components. An alarm or activation button is movably mounted on the housing and in selective contact with the main circuit board such that when the activation button is depressed relative to the housing, a silent alarm along with a video and audio feed is sent to the remote monitoring system. The personal safety device can further include a global positioning unit and/or a heart rate monitor module.

Abstract: A peptide sequence of a guide protein for the production of a peptide of interest; a peptide sequence that has a similarity of at least 90% to SEQ. ID. NO 1; a nucleotide sequence encoding the guide protein; an expression vector comprising the nucleotide sequence; a host cell that expresses a fusion protein comprising a peptide of interest; a method of production of a peptide of interest, comprising the steps of A) constructing an expression vector; B) inserting the expression vector into a host cell; C) expressing the fusion protein, culturing the host cell in a culture medium; D) recovering the accumulated fusion protein in the host cell; E) cleaving the fusion protein; F) purifying the peptide of interest.

Abstract: A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality.

Abstract: The invention is directed to an activated halo-containing aralkylsilanes possessing at least one hydrolyzable group bonded to a silicon atom and at least one halo functional group bonded to a carbon atom to which both the silicon atom and an aromatic group are covalently bonded. The invention is also directed to a process for making such a silane as well as its use in rubber compositions and articles containing such rubber compositions, such as tires.

Abstract: A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality.

Abstract: A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality.

Abstract: The invention is directed to an activated halo-containing aralkylsilanes possessing at least one hydrolyzable group bonded to a silicon atom and at least one halo functional group bonded to a carbon atom to which both the silicon atom and an aromatic group are covalently bonded. The invention is also directed to a process for making such a silane as well as its use in rubber compositions and articles containing such rubber compositions, such as tires.

Abstract: A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality.

Abstract: The present invention relates to the silanization or surface treatment of minerals with alkylsilanes and alkylsilane copolymers. More specifically, the present invention relates to alkylsilane copolymers useful for surface treating pigments or fillers. The alkylsilane copolymers comprise at least two different monomers. The copolymers find particular utility for the surface treatment of white pigments, such as titanium dioxide, for improving the dispersibility and processibility of the pigments when compounded with a polymeric material, in particular, when compounded with polyolefins.

Abstract: A laser diode or laser diode bar mounted on a heat sink and having an insulating layer of greater thickness also mounted on the heat sink requires a lead overlying both the insulating layer and the diode to bend downward for making electrical contact. Failures have been found to occur at the bend. The provision of a pattern of slots at the bend alleviates the problem by reducing stress there. The use of such slotted leads is disclosed for diodes or diode bars individually or in a stack arrangement.

Abstract: Diffusion bonding techniques are extended to the simultaneous bonding of an array of multilevel piece parts. The problems of uneven expansion and contraction of different levels of different piece parts in the array are obviated by positioning each level of the array within a frame. The stack of frames is pinned in one corner. The opposite corner of the array has a slot at a 45° angle with respect to the x and y axes of the array. The slot engages a pin and allows the entire array to expand and contract along the slot in a manner to maintain the registration of features between respective levels of each piece part.