Abstract: The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.

Abstract: The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g. pharmacokinetic and/or physicochemical properties) compared to the same active protein not linked to mucin-domain polypeptide, as well as methods for making and using the fusion proteins of the invention.

Abstract: The present invention relates to a low pressure water filter and dispenser system for use in a refrigerator which enables an effluent from said system exhibiting a log 6 bacteria reduction and a log 4 virus reduction with pressures as low as 0.35 kg/cm2 (5 psi). The system can be located in various places, for example it can sit on the shelf, it can be mounted to the ceiling of the refrigerator, or it can be attached to the wall or other internal components.

Abstract: A medium for storing a biological sample, in particular sperm, oocytes, embryos and stem cells, in a refrigerated, frozen or vitrified state.

Abstract: Method and system for emission control of a compression ignition locomotive engine. The method includes measuring an actual power level of the engine, comparing a desired power level with the actual power level of the engine; implementing a combustion strategy based on the comparing of the desired and the actual power levels; and implementing an emission strategy based on the combustion strategy. The emission strategy is intended to attain a predetermined emission level in the exhaust from the engine.

Abstract: A footwear fabrication process and product are disclosed. The footwear is characterized by flexibility, lightness and excellent ventilation.