Patents by Inventor Juan Botas
Juan Botas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7848888Abstract: The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.Type: GrantFiled: July 14, 2003Date of Patent: December 7, 2010Assignees: Vitruvean LLC, Baylor College of Medicine, European Molecular Biology LaboratoryInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Patent number: 7847146Abstract: The present invention discloses a double transgenic fly that expresses both Tau protein and the human A?42 peptide of human amyloid-? precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human A?42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.Type: GrantFiled: May 25, 2004Date of Patent: December 7, 2010Assignee: Baylor College of MedicineInventors: Juan Botas, Diego Rincon-Limas, Pedro Fernandez-Funez, Ismael Al-Ramahi
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Publication number: 20090202108Abstract: A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.Type: ApplicationFiled: September 15, 2008Publication date: August 13, 2009Applicants: EnVivo Pharmaceuticals, Inc., European Molecular Biology Laboratory, Baylor College of MedicineInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Publication number: 20050114912Abstract: The present invention discloses a double transgenic fly that expresses both Tau protein and the human A?42 peptide of human amyloid-? precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human A?42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.Type: ApplicationFiled: May 25, 2004Publication date: May 26, 2005Inventors: Juan Botas, Diego Rincon-Limas, Pedro Fernandez-Funez, Ismael Al-Ramahi
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Publication number: 20040194158Abstract: The present invention discloses a double transgenic fly that expresses both human Tau protein and the human A&bgr;42 peptide of human amyloid-&bgr; precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either human Tau or human A&bgr;42 alone. Thus, the flies provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.Type: ApplicationFiled: March 28, 2003Publication date: September 30, 2004Applicant: Baylor College of MedicineInventors: Juan Botas, Diego Rincon-Limas, Pedro Fernandez-Funez, Ismael Al-Ramahi
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Publication number: 20040177388Abstract: The present invention relates to Drosophila models of the neurodegenerative disorder spinocerebellar ataxia 1 (SCA-1). In particular, the invention relates to transgenic Drosophila which express normal human ataxin-1 or mutant human ataxin-1 with expanded polyglutamine repeats for SCA-1 therapeutics. The invention further relates to the diagnosis of predispositions to developing SCA-1. The invention further relates to methods of using the transgenic Drosophila to screen for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the identification of modifier genes of the SCA-1 phenotypes produced by overexpression of ataxin-1, for therapeutic and diagnostic uses and for screening for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the diagnosis of a predisposition to SCA-1 comprising detecting the overexpression of normal ataxin-1.Type: ApplicationFiled: November 8, 2002Publication date: September 9, 2004Applicant: Baylor College of MedicineInventors: Juan Botas, Huda Zoghbi, Pedro Fernandez-Funez
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Publication number: 20040126319Abstract: The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.Type: ApplicationFiled: October 1, 2003Publication date: July 1, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edvard Falt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Publication number: 20040076583Abstract: The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.Type: ApplicationFiled: July 14, 2003Publication date: April 22, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Publication number: 20040076999Abstract: Tools are provided for obtaining and assessing data concerning the physical or behavioral traits of an biological specimen population for the purpose of identifying, treating, or gathering intelligence on the condition of the specimen population. In one aspect, a computer system is provided to assess a condition of a biological specimen by studying the physical traits of a sample that comprises a number of specimens. The condition may comprise a human central nervous system condition. A user interface is provided that comprises a computer screen, an input interface portion, and a processing mechanism. The user interface may further comprise a specimen information input mechanism. The specimen information input mechanism may comprise a specimen type input that allows the user to specify, through the computer screen input, the type of specimen to be studied.Type: ApplicationFiled: July 14, 2003Publication date: April 22, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Publication number: 20040076318Abstract: A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.Type: ApplicationFiled: July 14, 2003Publication date: April 22, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi