Patents by Inventor Juan C. Jaen

Juan C. Jaen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arylsulfonanilide derivatives
    Patent number: 6153585
    Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: November 28, 2000
    Assignee: Tularik Inc.
    Inventors: Steven M. Rubenstein, Juan C. Jaen
  • Method of imaging amyloid deposits
    Patent number: 6001331
    Abstract: The present invention provides a method of imaging amyloid deposits and radiolabeled compounds useful in imaging amyloid deposits. The invention also provides a method of delivering a therapeutic agent to amyloid deposits, a method of inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of determining a compound's ability to inhibit aggregation of amyloid proteins.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: December 14, 1999
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, John L. Gilmore, Sheryl J. Hays, Juan C. Jaen, Harry LeVine, III
  • Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5620988
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
    Patent number: 5534522
    Abstract: The [1:1] maleate salt of [R-(Z)]-1-Azabicyclo [2.2.1]heptan-3-one, O-[3-(3-methoxyphenyl)-2-propynyl]-oxime, a known muscarinic agonist has unique properties relative to other salts of the compound, rendering it a desirable pharmaceutical.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 9, 1996
    Assignee: Warner-Lambert Company
    Inventors: Howard Y. Ando, Stephen D. Barrett, Juan C. Jaen, Steven E. Rose, Haile Tecle
  • Preparation of stereochemically pure oximes with muscarinic activity
    Patent number: 5514812
    Abstract: The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo 2.2.1!heptan-3-one and 1-azabicyclo 2.2.2!heptan-3-one oximes to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: May 7, 1996
    Assignee: Warner-Lambert Company
    Inventors: Ruth Bucsh, Juan C. Jaen, Edgardo Laborde, Anthony J. Thomas
  • Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5466698
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists
    Patent number: 5446057
    Abstract: Substituted tetrahydropyridines and piperidinecarboxylic acids and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which muscarinic antagonists are useful as agents for inhibiting gastric acid release, for treating bradycardia, bronchoconstriction, urinary incontinence, atonic conditions of the gut and bladder, Parkinson's disease, dystonias, and Alzheimer's disease.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: August 29, 1995
    Assignee: Warner-Lambert Company
    Inventors: Corinne E. Augelli-Szafran, Juan C. Jaen, Roy Schwarz, Anthony J. Thomas
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5409931
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: April 25, 1995
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
    Patent number: 5346911
    Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds which are azabicyclo[2.2.1]oximes, azabicyclo[2.2.2]oximes, azabicyclo[2.2.1]amines, azabicyclo[2.2.2]amines, azabicyclo[3.2.1]oximes, and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 3 to 7 carbon atoms are disclosed.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: September 13, 1994
    Assignee: Warner-Lambert Company
    Inventors: Corinne E. Augelli-Szafran, Stephen D. Barrett, Bradley W. Caprathe, Adam A. Galan, Juan C. Jaen, David J. Lauffer, Walter H. Moos, Michael R. Pavia, Kathryn B. Sanders, Haile Tecle, Anthony J. Thomas
  • Pyrazoloquinazolone derivatives as neurotrophic agents
    Patent number: 5342942
    Abstract: Pyrazolo[5,1-b]quinazoline compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds, and methods for treating neurodegenerative disorders, tumors of neuronal origin, inflammation, allergy, and pain, and methods for screening compounds that interact with the neurotrophic receptors using said compositions are disclosed.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: August 30, 1994
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, Bradley W. Caprathe
  • Fused pyridazinoquinazolone derivatives as neurotrophic agents
    Patent number: 5340808
    Abstract: Fused pyridazinoquinazoline compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating neurodegenerative disorders using said compositions are disclosed.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: August 23, 1994
    Assignee: Warner Lambert Company
    Inventors: Juan C. Jaen, Bradley W. Caprathe
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5314896
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: May 24, 1994
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
    Patent number: 5273977
    Abstract: Substituted tetrahydropyridines and hydroxypiperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: December 28, 1993
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted piperazines as central nervous system agents
    Patent number: 5270312
    Abstract: Substituted piperazines and derivatives of Formula I ##STR1## are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: December 14, 1993
    Assignee: Warner-Lambert Company
    Inventors: Shelly Glase, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5198443
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: March 30, 1993
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted tetrahydropyridines and their use as central nervous system agents
    Patent number: 5187280
    Abstract: Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: August 16, 1991
    Date of Patent: February 16, 1993
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, David G. Nickell, Donna M. Reynolds, Sarah J. Smith, Lawrence D. Wise, David J. Wustrow
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5120748
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: June 9, 1992
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted tetrahydropyridines as central nervous system agents
    Patent number: 5118691
    Abstract: Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: June 2, 1992
    Assignee: Warner-Lambert Co.
    Inventors: Juan C. Jaen, David G. Nickell, Donna M. Reynolds, Sarah J. Smith, Lawrence D. Wise, David J. Wustrow
  • Substituted piperazines as central nervous system agents
    Patent number: 5089497
    Abstract: Substituted piperazines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: February 18, 1992
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, David G. Nickell, Donna M. Reynolds, Sarah J. Smith, Lawrence D. Wise, David J. Wustrow
  • Substituted cyclohexanols as central nervous system agents
    Patent number: 5047406
    Abstract: Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: September 10, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise