Patents by Inventor Juan Carlos Jaume

Juan Carlos Jaume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistic Inhibition of eIF5A and Notch Signaling
    Publication number: 20240148789
    Abstract: Methods for inducing plasticity in effector T cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the synergstic inhibition of eIF5A and Notch signaling. Also described are compositions and kits including an eIF5A inhibitor and a Notch signaling inhibitor.
    Type: Application
    Filed: July 17, 2023
    Publication date: May 9, 2024
    Applicant: The University of Toledo
    Inventors: Shahnawaz Imam, Juan Carlos Jaume
  • Transgenic C57BL6-BTBR mouse with a humanized MHC II gene that expresses GAD65
    Patent number: 11974552
    Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: May 7, 2024
    Assignee: The University of Toledo
    Inventors: Shahnawaz Imam, Maria Alfonso-Jaume, Juan Carlos Jaume
  • Immunosuppressive Antigen-Specific Chimeric Antigen Receptor Treg Cells for Prevention and/or Treatment of Autoimmune and Alloimmune Disorders
    Publication number: 20240100094
    Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
    Type: Application
    Filed: August 23, 2023
    Publication date: March 28, 2024
    Applicant: The University of Toledo
    Inventors: Juan Carlos Jaume, Shahnawaz Imam
  • Spontaneous Autoimmune Diabetes in Humanized Mice Carrying Human Type 1 Diabetes Susceptibility and Uses Therefor
    Publication number: 20200037586
    Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: The University of Toledo
    Inventors: Shahnawaz Imam, Maria Alfonso-Jaume, Juan Carlos Jaume