Patents by Inventor Juan Carlos SAEZ

Juan Carlos SAEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180050029
    Abstract: The present invention provides connexin hemichannel blockers for the treatment of epilepsy. In particular, the present invention relates to organic compounds which act as selective blockers connexin hemichannels which are useful in the treatment of epilepsy. In another embodiment of the present invention there is provided a composition comprising a selective connexin hemichannels blocker compounds useful in the treatment of epilepsy in combination with other antiepileptic compounds.
    Type: Application
    Filed: February 29, 2016
    Publication date: February 22, 2018
    Inventors: Juan Carlos SAEZ, Carlos LAGOS, Carola MATURANA
  • Publication number: 20170115276
    Abstract: The invention provides identification methods of specific modulators of hemichannels formed by connexin through the use of structural bioinformation methods for the calculation of the interaction energy with ligands and compositions to selectively modulate the activity of hemichannels formed by connexins. Among other aspects, the invention describes a computer-aided method, where estimating the interaction energy between ligands coming from a database of chemical compounds is possible, with a binding pocket defined by the region comprising the residues of 3-10 (NTH), 29-40 (TM1), 74-93 (TM2) of a protomer and residues 29-40 (TM1) of an adjacent protomer in connexin 26 or the equivalent residues in other connexins.
    Type: Application
    Filed: April 14, 2015
    Publication date: April 27, 2017
    Applicant: PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE º
    Inventors: Juan Carlos SAEZ, Carlos LAGOS