Patents by Inventor Juan Carlos Zuniga-Pflucker

Juan Carlos Zuniga-Pflucker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR GENERATING CELLS OF THE T CELL LINEAGE
    Publication number: 20200399599
    Abstract: A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell lineage. In one embodiment, the cells of the T-cell lineage are progenitor T cells or mature T cells. Compositions, kits and uses thereof are also provided.
    Type: Application
    Filed: February 14, 2019
    Publication date: December 24, 2020
    Inventors: Juan Carlos Zuniga-Pflucker, Mahmood Mohtashami, Ashton Trotman-Grant
  • METHODS OF MAKING, EXPANDING, AND USING A HUMAN PROGENITOR T CELL
    Publication number: 20200308540
    Abstract: A CD7+ progenitor T cell, a method of producing the CD7+ progenitor T cell, and a method of administering the CD7+ progenitor T cell. The method of producing the CD7+ progenitor T cell includes expanding CD34+ cells.
    Type: Application
    Filed: September 28, 2018
    Publication date: October 1, 2020
    Inventors: Heather Emily Stefanski, John Edward Wagner, Jr., Bruce Robert Blazar, Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker
  • Human progenitor T-cells into NK cells
    Patent number: 10266805
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: April 23, 2019
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • Populations of hematopoietic progenitors and methods of enriching stem cells therefor
    Patent number: 9834754
    Abstract: There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34+CD43?, CD31+CD43? and CD144+CD43?. Also provided are populations of hematopoietic progenitors obtained by the methods described herein.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: December 5, 2017
    Assignees: UNIVERSITY HEALTH NETWORK, SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Gordon Keller, Juan Carlos Zuniga-Pflucker, Marion J. Kennedy, Christopher Michael Sturgeon, Andrea Ditadi, Geneve Sheandra Awong
  • HUMAN PROGENITOR T-CELLS
    Publication number: 20170121684
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 4, 2017
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • Producing human CD34+CD7+CD5+CD1a? progenitor T cells and method of treatment
    Patent number: 9533009
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: January 3, 2017
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • POPULATIONS OF HEMATOPOIETIC PROGENITORS AND METHODS OF ENRICHING STEM CELLS THEREFOR
    Publication number: 20140322808
    Abstract: There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34+CD43?, CD31+CD43? and CD144+CD43?. Also provided are populations of hematopoietic progenitors obtained by the methods described herein.
    Type: Application
    Filed: November 21, 2012
    Publication date: October 30, 2014
    Applicants: SUNNYBROOK RESEARCH INSTITUTE, UNIVERSITY HEALTH NETWORK
    Inventors: Gordon Keller, Juan Carlos Zuniga-Pflucker, Marion J. Kennedy, Christopher Michael Sturgeon, Andrea Ditadi, Geneve Sheandra Awong
  • HUMAN PROGENITOR T-CELLS
    Publication number: 20140248248
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 4, 2014
    Applicant: Sunnybrook Health Sciences Centre
    Inventors: JUAN CARLOS ZUNIGA-PFLUCKER, GENEVE AWONG, ROSS LA MOTTE-MOHS
  • CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using
    Patent number: 8772028
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: July 8, 2014
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • HUMAN PROGENITOR T-CELLS
    Publication number: 20110274671
    Abstract: Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a?CD5? or CD34+CD7+CD1a?CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
    Type: Application
    Filed: November 6, 2009
    Publication date: November 10, 2011
    Inventors: Juan Carlos Zuniga-Pflucker, Geneve Awong, Ross La Motte-Mohs
  • Cell preparations comprising cells of the T cell lineage and methods of making and using them
    Patent number: 7575925
    Abstract: The invention relates to cell preparations comprising cells of the T cell lineage, methods for preparing same, and uses of the cell preparations.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 18, 2009
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Thomas M. Schmitt, Juan Carlos Zuniga-Pflucker
  • Cell preparations comprising cells of the T cell lineage and methods of making and using them
    Publication number: 20040171148
    Abstract: The invention relates to cell preparations comprising cells of the T cell lineage, methods for preparing same, and uses of the cell preparations.
    Type: Application
    Filed: December 10, 2003
    Publication date: September 2, 2004
    Inventors: Thomas M. Schmitt, Juan Carlos Zuniga-Pflucker