Abstract: The present disclosure relates to a use of an ADAM9 inhibitor in manufacture of an immunomodulator. The immunomodulator can change the distribution of immune cells in a tumor and increase the infiltration of the immune cells, thereby increasing the efficacy of cancer immunotherapy. Furthermore, the immunomodulator can be used to enhance an effectiveness of a cancer immunotherapy, and the ADAM9 inhibitor can be a compound of Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof.

Abstract: The present disclosure relates to an ADAM9 inhibitor compound of formula (I), including salts, hydrates and stereoisomers thereof, compositions thereof, and methods of use therefor, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Abstract: A process of assigning a colour grade to a diamond, including the steps of (i) determining the N3 and C-center content of a diamond (110); (ii) comparing the N3 and C-center content of the diamond with a previously acquired data set from a plurality of diamonds each having a colour grading previously assigned thereto, and (iii) assigning a colour grade to the diamond upon a correlation of the N3 and C-center content of said diamond with a grade of said previously acquired data set; wherein said previously acquired data set comprises a correlation between N3 and C center content and optical absorbance in the visible light spectrum for each diamond of said plurality of diamonds.

Abstract: A process operable using a computerized system (300) grades the clarity of a diamond (315, 400) as a function of internal defects within its body (315, 400). The computerized system (300) includes an optical image acquisition device (310), a processor module (320) and an output module (340) operably interconnected together. The process includes the steps of (i) acquiring via an optical image acquisition device (310) a plurality of top view images of a diamond (315, 400); (ii) in a processor module (320), detecting defects within the body of the diamond (315, 400); and (iii) from an output module (340), providing a signal indicative of the clarity grade assigned in (ii).

Abstract: The present disclosure provides a voltage reference source circuit for generating a reference voltage, the voltage reference source circuit comprises a starting circuit, a current generating circuit, and an output voltage reference circuit electrically connected in sequence. The starting circuit provides a starting voltage for the voltage reference source circuit to prevent the voltage reference source circuit from operating in zero state area. The current generating circuit generates a working current for the output voltage reference circuit; and the output voltage reference circuit is used to realize the reference voltage output with zero temperature coefficient according to the working current output by the current generating circuit. A low power consumption power supply system is also disclosed.

Abstract: A system (100a) for determining the type of a diamond (130a), the system (100a) comprising a plurality of lasers (110a,120a) for directing light towards a diamond (130a), wherein each laser is of a different wavelength of light; wherein the spectrum of light from the plurality of lasers (110a,120a) extends from ultra-violet to near infra-red; a spectrometer (140a) for collecting luminescence spectrum from the diamond (130a) responsive to inhomogeneities upon light from the lasers (110a,120a) being directed towards the diamond (130a); a processor module (150a) for comparing photoluminescence spectrum collected by the spectrometer (140a) with pre-existing photoluminescence spectrum of known diamond type; and an output module (160a) for providing an output signal indicative of the diamond type of the diamond (130a), upon a predetermined threshold of correlation between the photoluminescence spectrum from the diamond (130a) and the pre-existing photoluminescence spectrum from the diamond (130a) and the pre-existi

Abstract: Degradable hyperbranched epoxy resin and a preparation method thereof, wherein the preparation method comprises carrying out a reaction between a cyclotriazine compound and a carboxyl-sourced compound to prepare a carboxyl-terminated or hydroxy-terminated hyperbranched polymer; then reacting with epoxy chloropropane to obtain a degradable hyperbranched epoxy resin of which the molecular weight is about 1,900-22,000 g/mol. After the degradable hyperbranched epoxy resin is cured, a cyclotriazine structure can be completely degraded within 2 h in a phosphoric acid solution at the temperature of 80° C., thus realizing the recycle of the epoxy resin. The invention has simple process, and the product is degradable and has self-strengthening and self-toughening functions, and is expected to be used in the fields of strengthening and toughening of epoxy resins, solvent-free coatings etc.

Abstract: A process operable using a computerized system (300) grades the clarity of a diamond (315, 400) as a function of internal defects within its body (315, 400). The computerized system (300) includes an optical image acquisition device (310), a processor module (320) and an output module (340) operably interconnected together. The process includes the steps of (i) acquiring via an optical image acquisition device (310) a plurality of top view images of a diamond (315, 400); (ii) in a processor module (320), detecting defects within the body of the diamond (315, 400); and (iii) from an output module (340), providing a signal indicative of the clarity grade assigned in (ii).

Abstract: The present disclosure relates to an ADAM9 inhibitor compound of formula (I), including salts, hydrates and stereoisomers thereof, compositions thereof, and methods of use therefor, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Abstract: A process operable using a computerized system (300) grades the clarity of a diamond (315, 400) as a function of internal defects within its body (315, 400). The computerized system (300) includes an optical image acquisition device (310), a processor module (320) and an output module (340) operably interconnected together. The process includes the steps of (i) acquiring via an optical image acquisition device (310) a plurality of top view images of a diamond (315, 400); (ii) in a processor module (320), detecting defects within the body of the diamond (315, 400); and (iii) from an output module (340), providing a signal indicative of the clarity grade assigned in (ii).

Abstract: Degradable sulfur-containing hyperbranched epoxy resin and a preparation method thereof. The preparation method comprises initiating a reaction of a mercaptocyclotriazine compound and a binary olefin by ultraviolet light to prepare a mercapto hyperbranched polymer; then reacting with glycidyl methacrylate to obtain a degradable sulfur-containing hyperbranched epoxy resin of which the molecular weight is about 3,000-35,400 g/mol. After the degradable sulfur-containing hyperbranched epoxy resin is cured, a cyclotriazine structure can be completely degraded within 1.5 h in a phosphoric acid solution at the temperature of 80 DEG C, thus realizing the recycle of the epoxy resin.

Abstract: The present disclosure relates to a component structure, a power module and a power module assembly structure having the component structure. The component structure comprises: a first bus bar, having one end extending to a first plane to form a first connecting terminal; a second bus bar, comprising a front portion of the second bus bar and a rear portion of the second bus bar, wherein the front portion of the second bus bar is laminated in parallel with the first bus bar, and the rear portion of the second bus bar is extended to a second plane to form a second connecting terminal; and an external circuit comprising a third bus bar, wherein the third bus bar is settled in parallel with the rear portion of the second bus bar, to reduce a parasitic inductance between the first connecting terminal and the second connecting terminal.

Abstract: A computerized system for grading the colour of a diamond, wherein the colour of the diamond is graded based on a predetermined threshold of correlation of colour of a diamond with the colour of a diamond of a plurality of diamonds each having a colour grading assigned thereto, the computerized system including: an optical image acquisition device for acquiring at least a first optical image of a diamond, wherein the first optical image is acquired at a predetermined angle of inclination to the central axis extending normal to the table and through the apex of the pavilion of the diamond and in a direction of towards the table and wherein the first optical image is acquired in an environment having a predetermined constant light level; a processor module for comparing data derived from acquisition of the at least a first optical image with a plurality of data sets each of which corresponds to a diamond of a plurality of diamonds, wherein data sets are each derived from an optical image acquired by an optical

Abstract: The present disclosure relates to a component structure, a power module and a power module assembly structure having the component structure. The component structure comprises: a first bus bar, having one end extending to a first plane to form a first connecting terminal; a second bus bar, comprising a front portion of the second bus bar and a rear portion of the second bus bar, wherein the front portion of the second bus bar is laminated in parallel with the first bus bar, and the rear portion of the second bus bar is extended to a second plane to form a second connecting terminal; and an external circuit comprising a third bus bar, wherein the third bus bar is settled in parallel with the rear portion of the second bus bar, to reduce a parasitic inductance between the first connecting terminal and the second connecting terminal.

Abstract: A power module structure includes a first metal layer, a second metal layer, a third metal layer and a fourth metal layer, wherein the fourth metal layer is connected to the second metal layer via a connecting bridge; at least one first switch including a first end connected to the third metal layer and a second end connected to the second metal layer; and at least one second switch including a third end connected to the fourth metal layer and a fourth end connected to the first metal layer; wherein the projection of the first metal layer and the projection of the third metal layer are overlapped to form a first overlapping area; wherein the direction of the current flowing through the first metal layer is opposite to the direction of the current flowing through the third metal layer.

Abstract: Degradable hyperbranched epoxy resin and a preparation method thereof, wherein the preparation method comprises carrying out a reaction between a cyclotriazine compound and a carboxyl-sourced compound to prepare a carboxyl-terminated or hydroxy-terminated hyperbranched polymer; then reacting with epoxy chloropropane to obtain a degradable hyperbranched epoxy resin of which the molecular weight is about 1,900-22,000 g/mol. After the degradable hyperbranched epoxy resin is cured, a cyclotriazine structure can be completely degraded within 2 h in a phosphoric acid solution at the temperature of 80 ° C., thus realizing the recycle of the epoxy resin. The invention has simple process, and the product is degradable and has self-strengthening and self-toughening functions, and is expected to be used in the fields of strengthening and toughening of epoxy resins, solvent-free coatings etc.

Abstract: Degradable sulfur-containing hyperbranched epoxy resin and a preparation method thereof. The preparation method comprises initiating a reaction of a mercaptocyclotriazine compound and a binary olefin by ultraviolet light to prepare a mercapto hyperbranched polymer; then reacting with glycidyl methacrylate to obtain a degradable sulfur-containing hyperbranched epoxy resin of which the molecular weight is about 3,000-35,400 g/mol. After the degradable sulfur-containing hyperbranched epoxy resin is cured, a cyclotriazine structure can be completely degraded within 1.5 h in a phosphoric acid solution at the temperature of 80 DEG C, thus realizing the recycle of the epoxy resin.

Abstract: A computerized system for grading the colour of a diamond, wherein the colour of the diamond is graded based on a predetermined threshold of correlation of colour of a diamond with the colour of a diamond of a plurality of diamonds each having a colour grading assigned thereto, the computerized system including: an optical image acquisition device for acquiring at least a first optical image of a diamond, wherein the first optical image is acquired at a predetermined angle of inclination to the central axis extending normal to the table and through the apex of the pavilion of the diamond and in a direction of towards the table and wherein the first optical image is acquired in an environment having a predetermined constant light level; a processor module for comparing data derived from acquisition of the at least a first optical image with a plurality of data sets each of which corresponds to a diamond of a plurality of diamonds, wherein data sets are each derived from an optical image acquired by an optical

Abstract: The present disclosure relates to a component structure, a power module and a power module assembly structure having the component structure. The component structure comprises: a first bus bar, having one end extending to a first plane to form a first connecting terminal; a second bus bar, comprising a front portion of the second bus bar and a rear portion of the second bus bar, wherein the front portion of the second bus bar is laminated in parallel with the first bus bar, and the rear portion of the second bus bar is extended to a second plane to form a second connecting terminal; and an external circuit comprising a third bus bar, wherein the third bus bar is settled in parallel with the rear portion of the second bus bar, to reduce a parasitic inductance between the first connecting terminal and the second connecting terminal.

Abstract: A power plug is provided. The power plug may include a plug insert having a handle, and a plug body including a plurality of insulation layers and a plurality of conducting strips sandwiched between the pluralities of insulation layers. Each of the plurality of conducting strips may have an end extending into the handle and the other end forming or electrically connected to a conducting contact point exposed on a surface of the plug body.