Patents by Inventor Juan Cubillos-Ruiz

Juan Cubillos-Ruiz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD161 ligand, pilar, for modulating activation and proliferation of T cells
    Patent number: 8084217
    Abstract: The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly up-regulated on both CD4 and CD8 T cells upon TCR engagement and increases the expression of anti-apoptotic genes and glucose transporters through CD161, which globally results in a dramatic enhancement of T cell proliferation. Agents which stimulate or block this activity are also provided as are methods for manipulating PILAR signaling in the treatment of disease.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: December 27, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Jose R. Conejo-Garcia, Eduardo Huarte-Sobrino, Juan Cubillos-Ruiz, Yolanda Nesbeth, Diana G. Martinez
  • CD161 LIGAND, PILAR, FOR MODULATING ACTIVATION AND PROLIFERATION OF T CELLS
    Publication number: 20100143363
    Abstract: The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly up-regulated on both CD4 and CD8 T cells upon TCR engagement and increases the expression of anti-apoptotic genes and glucose transporters through CD161, which globally results in a dramatic enhancement of T cell proliferation. Agents which stimulate or block this activity are also provided as are methods for manipulating PILAR signaling in the treatment of disease.
    Type: Application
    Filed: April 10, 2008
    Publication date: June 10, 2010
    Inventors: Jose R. Conejo-Garcia, Eduardo Huarte-Sobrino, Juan Cubillos-Ruiz, Yolanda Nesbeth, Diana G. Martinez