Patents by Inventor Juan Diego Naranjo Gutierrez
Juan Diego Naranjo Gutierrez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11707485Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.Type: GrantFiled: November 12, 2021Date of Patent: July 25, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Juan Diego Naranjo Gutierrez, Lindsey Tamiko Saldin
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Publication number: 20220354473Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).Type: ApplicationFiled: January 21, 2022Publication date: November 10, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Lindsey Tamiko Saldin, Juan Diego Naranjo Gutierrez
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Publication number: 20220331486Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an esophagus of a subject. These methods include injecting submucosally into the esophagus of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa). The ECM hydrogel is not a urinary bladder ECM hydrogel.Type: ApplicationFiled: March 7, 2022Publication date: October 20, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Lindsey Tamiko Saldin, Juan Diego Naranjo Gutierrez
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Publication number: 20220249549Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.Type: ApplicationFiled: November 12, 2021Publication date: August 11, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Juan Diego Naranjo Gutierrez, Lindsey Tamiko Saldin
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Patent number: 11213545Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.Type: GrantFiled: March 2, 2018Date of Patent: January 4, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Juan Diego Naranjo Gutierrez, Lindsey Tamiko Saldin
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Publication number: 20210268148Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of the esophagus of a subject. These methods include injecting submucosally into the region of the esophagus of the subject a pharmaceutical composition comprising a urinary bladder extracellular matrix (ECM) hydrogel, to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 20 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa).Type: ApplicationFiled: June 20, 2019Publication date: September 2, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Lindsey Tamiko Saldin, Juan Diego Naranjo Gutierrez
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Publication number: 20210260246Abstract: A composition is disclosed herein that includes isolated ECM-derived nanovesicles and a pharmaceutically acceptable carrier. Methods are producing the ECM-derived nanovesicles are also disclosed. These ECM-derived nanovesicles can be included in pharmaceutical compositions, bioscaffolds, and devices. Methods for using these ECM-derived nanovesicles are provided.Type: ApplicationFiled: October 16, 2020Publication date: August 26, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Luai Huleihel, George S. Hussey, Juan Diego Naranjo Gutierrez
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Publication number: 20210244855Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an esophagus of a subject. These methods include injecting submucosally into the esophagus of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa). The ECM hydrogel is not a urinary bladder ECM hydrogel.Type: ApplicationFiled: June 20, 2019Publication date: August 12, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Lindsey Tamiko Saldin, Juan Diego Naranjo Gutierrez
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Publication number: 20210244396Abstract: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).Type: ApplicationFiled: June 20, 2019Publication date: August 12, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Lindsey Tamiko Saldin, Juan Diego Naranjo Gutierrez
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Publication number: 20200009187Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.Type: ApplicationFiled: March 2, 2018Publication date: January 9, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Juan Diego Naranjo Gutierrez, Lindsey Tamiko Saldin
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Publication number: 20190117837Abstract: A composition is disclosed herein that includes isolated ECM-derived nanovesicles and a pharmaceutically acceptable carrier. Methods are producing the ECM-derived nanovesicles are also disclosed. These ECM-derived nanovesicles can be included in pharmaceutical compositions, bioscaffolds, and devices. Methods for using these ECM-derived nanovesicles are provided.Type: ApplicationFiled: March 2, 2017Publication date: April 25, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen Francis Badylak, Luai Huleihel, George S. Hussey, Juan Diego Naranjo Gutierrez