Patents by Inventor Juan G. Alvarez

Juan G. Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8634067
    Abstract: Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: January 21, 2014
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Lev T. Perelman, Juan G. Alvarez, Mark D. Modell
  • Publication number: 20110122487
    Abstract: Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
    Type: Application
    Filed: May 11, 2005
    Publication date: May 26, 2011
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Lev T. Perelman, Juan G. Alvarez, Mark Modell
  • Publication number: 20040127567
    Abstract: A method of treating disorders in which DHA levels are affected is described. The method includes administering to a subject suffering from the disorder a therapeutically affective amount of DHA. This method is particularly useful in treating subjects suffering from a disorder characterized by a defect in the CF gene, e.g., cystic fibrosis, or a chronic inflammatory disorder, e.g., ulcerative colitis, Crohn's disease, chronic pancreatitis, asthma, rheumatoid arthritis or chronic gastritis. A method of ameliorating affects of cystic fibrosis in a newborn and a method of increasing surfactant levels in a fetus are also described.
    Type: Application
    Filed: April 8, 2003
    Publication date: July 1, 2004
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Steven Freedman, Juan G. Alvarez
  • Patent number: 6552081
    Abstract: A method of treating disorders in which DHA levels are affected is described. The method includes administering to a subject suffering from the disorder a therapeutically affective amount of DHA. This method is particularly useful in treating subjects suffering from a disorder characterized by a defect in the CF gene, e.g., cystic fibrosis, or a chronic inflammatory disorder, e.g., ulcerative colitis, Crohn's disease, chronic pancreatitis, asthma, rheumatoid arthritis or chronic gastritis. A method of ameliorating affects of cystic fibrosis in a newborn and a method of increasing surfactant levels in a fetus are also described.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: April 22, 2003
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Steven Freedman, Juan G. Alvarez
  • Patent number: 6180671
    Abstract: A method of treating disorders in which DHA levels are affected is described. The method includes administering to a subject suffering from the disorder a therapeutically affective amount of DHA. This method is particularly useful in treating subjects suffering from a disorder characterized by a defect in the CF, gene, e.g. cystic fibrosis, or a chronic inflammatory disorder, e.g., ulcerative colitis, Crohn's disease, chronic pancreatitis, asthma, rheumatoid arthritis or chronic gastritis. A method of ameliorating affects of cystic fibrosis in a newborn and a method of increasing surfactant levels in a fetus are also described.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: January 30, 2001
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Steven Freedman, Juan G. Alvarez
  • Patent number: 5935800
    Abstract: Assays and kits for identifying fertile sperm samples (e.g. for use in an assisted reproductive technology or as an indication of an ineffective male contraception (vasectomy)) and sub-fertile sperm samples (e.g. as an indication of a potentially infertile male donor or an effective male contraception) are disclosed.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: August 10, 1999
    Assignee: Beth Israel Deaconess Medical Center
    Inventor: Juan G. Alvarez
  • Patent number: 5912179
    Abstract: Systems and methods for material analysis are disclosed in which an organic sample (e.g., a foodstuff, tissue sample or petroleum product) is illuminated at a plurality of discrete wavelengths which are absorbed by fatty acid and fatty acid oxidation products in the sample. Measurements of the intensity of reflected or absorbed light at such wavelengths are taken, and a analysis of absorbance ratios for various wavelengths is performed. Changes in the reflection ratios are correlated with the oxidative state of fatty acids present in the material.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: June 15, 1999
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Juan G. Alvarez, Mark Modell
  • Patent number: 5895749
    Abstract: Kits and assays, incorporating antibodies specific for glutathione peroxidase, for determining the fertilizing ability of a male at home or in a clinical laboratory are disclosed.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 20, 1999
    Assignee: Beth Israel Deaconess Medical Center
    Inventor: Juan G. Alvarez
  • Patent number: 5856196
    Abstract: Processes for detecting or quantitating a particular phosphoglyceride in a sample containing the phosphoglyceride and other lipids and clinical uses for the process (e.g. for diagnosing improperly functioning lungs and other conditions) are disclosed.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: January 5, 1999
    Assignee: Beth Israel Hospital
    Inventors: Juan G. Alvarez, Jack Ludmir
  • Patent number: 5712165
    Abstract: Systems and methods for material analysis are disclosed in which an organic sample (e.g., a foodstuff, tissue sample or petroleum product) is illuminated at a plurality of discrete wavelengths which are absorbed by fatty acid and fatty acid oxidation products in the sample. Measurements of the intensity of reflected or absorbed light at such wavelengths are taken, and a analysis of absorbance ratios for various wavelengths is performed. Changes in the reflection ratios are correlated with the oxidative state of fatty acids present in the material.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: January 27, 1998
    Assignee: Beth Israel Hospital Administration
    Inventors: Juan G. Alvarez, Mark Modell
  • Patent number: 5443989
    Abstract: The present invention provides an accurate, rapid and precise methodology for assessing maturity of the lungs in a fetus prior to birth, especially for premature fetuses having a gestation period of 37 weeks or less. The methodology quantitatively measures a specific phosphoglyceride, dipalmitoyl phosphatidyl choline, in samples of amniotic fluid for the assessment of fetal lung maturity. The process enzymatically cleaves such phophoglycerides and preferably detects the resulting diacylglycerols by HPTLC-reflectance spectrodensitometry.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: August 22, 1995
    Assignee: Beth Israel Hospital Association
    Inventors: Juan G. Alvarez, Jack Ludmir