Abstract: Pharmaceutical composition comprising growth-hormone releasing peptide 6 (GHRP-6), tartrate buffer at pH 5.0-6.0, and trehalose as stabilizing agent, as well as the use of said composition for the manufacture of a medicament. The invention also provides a kit of parts comprising said pharmaceutical composition and a method of treatment of an individual in need thereof, which entails the administration of a therapeutically effective amount of the pharmaceutical composition comprising of GHRP-6, tartrate buffer at pH 5.0-6.0 and trehalose.

Abstract: An adapter for use with a tattoo machine is disclosed. The adapter may enable a tattoo machine configured with a wireless battery pack to switch to a wired configuration by removing the wireless battery pack and replacing it with the adapter. One end of the adapter may be affixed to a portion of the tattoo machine so that the adapter may deliver power to the componentry of the tattoo machine to facilitate the operation of the tattoo machine. The other end of the adapter may include a connector for enabling connection of the adapter to a power supply or power source so that power may be delivered from the power supply or power source through the adapter and to the tattoo machine. When the tattoo machine is powered, the motor of the tattoo machine may reciprocate a needle included in a needle cartridge affixed to the tattoo machine.

Abstract: Disclosed herein are homology-independent targeted integration methods of integrating an exogenous DNA sequence into a genome of a non-dividing cell and compositions for such methods. Methods herein comprise contacting the non-dividing cell with a composition comprising a targeting construct comprising the exogenous DNA sequence and a targeting sequence, a complementary strand oligonucleotide homologous to the targeting sequence, and a nuclease, thereby altering the genome of the non-dividing cell.

Abstract: A parking facility access management system having a sensing device communicatively connected to the internet and to a mechanism for providing access to a parking facility. A mobile device is communicatively connected to the sensing device while in proximity to the sensing device, and also communicatively connected to the internet while not in proximity to the sensing device. As the mobile device enters proximity to the sensing device, the mobile device communicates exclusively with the sensing device and not the internet. In some embodiments, as the mobile device enters proximity to the sensing device, the mobile device sends a signal to the sensing device to alert the mechanism for providing access to provide access to the parking facility.

Abstract: Techniques described herein are directed to an intelligent lending platform in which a payment service may receive respective lending queries from users, analyze the queries using a machine-learned model and, if the queries are denied, output respective signals indicating that the respective queries are denied and the reasons for each respective decline. In some instances, the described techniques analyze data associated with each respective denied query to determine high-level reasons for the decline and may present these reasons in a manner that is both understandable to and actionable by the respective user. That is, the techniques may automatically identify the most significant reasons why a particular lending query was denied and may automatically output these reasons to a user in a manner that the user is able to easily comprehend and act upon to increase the chance of receiving an approval upon a subsequent lending query.

Abstract: The disclosure relates to a surgical staple defining a median folding zone which is continued by a pair of branches, each branch having a pointed fastening end and an intermediate clamping zone situated between the median folding zone and the pointed fastening end. The staple is deformable so that each branch can be folded relative to the median folding zone by causing each fastening end to approach the other branch, the staple being formed by a metal cutout pre-shaped by folding, and is of constant thickness. Intermediate clamping zones of the two branches are cut out such as to form at least two teeth, the edges of which form two complementary clamping surfaces, parallel to the median plane when the staple is folded. The cross-section of clamping surfaces correspond to the cross-section of the metal cutout.

Abstract: The present disclosure provides modular magnetic anastomosis devices that can be implemented in digestive surgery or in any circumstance of anastomosis between adjacent organs or two hollow viscera. The device is minimally invasive and easily and quickly delivered using laparoscopic or endoscopic procedures.

Abstract: Systems, devices, and methods are described for providing, among other things, a device including a heartbeat mimetic unit configured to generate an acoustic stimulus that mimics a heartbeat. In an embodiment, the device includes a warm-touch unit configured to generate a thermal stimulus. In an embodiment, the device includes a controller unit operably coupled to the heartbeat mimetic unit and the warm touch unit, the controller unit configured to activate at least one of the heartbeat mimetic unit or the warm-touch unit. In an embodiment, the device includes a communication unit configured to exchange at least one of heartbeat mimetic data or warm-touch data with a remote network.

Abstract: An endoscopic needle holder for handling curved needles includes an articulated assembly including a first gripping jaw forming one piece with a duct and a second gripping jaw actuated by the movable core in transverse displacement; the jaws are made of coaxial cylindrical parts with the mobile core; the first jaw has a plurality of longitudinally extending peripheral teeth; the second jaw consists of a cylindrical part with a plurality of peripheral teeth; and the second jaw is movable with respect to the first jaw by a longitudinal linear displacement between a rest position, where the jaws are spaced to delimit, between the ends of the teeth, an interval at least equal to the section of a needle and a close position where they keep the needle curved.

Abstract: Systems and methods for presenting nucleic acid molecules for analysis are provided. The nucleic acid molecules have a central portion that is contained within a nanoslit. The nanoslit contains an ionic buffer. The nucleic acid molecule has a contour length that is greater than a nanoslit length of the nanoslit. An ionic strength of the ionic buffer and electrostatic or hydrodynamic properties of the nanoslit and the nucleic acid molecule combining to provide a summed Debye length that is greater than or equal to the smallest physical dimension of the nanoslit.

Abstract: The present disclosure provides modular magnetic anastomosis devices that can be implemented in digestive surgery or in any circumstance of anastomosis between adjacent organs or two hollow viscera. The device is minimally invasive and easily and quickly delivered using laparoscopic or endoscopic procedures.

Abstract: The disclosure relates to a surgical staple defining a median folding zone which is continued by a pair of branches, each branch having a pointed fastening end and an intermediate clamping zone situated between the median folding zone and the pointed fastening end. The staple is deformable so that each branch can be folded relative to the median folding zone by causing each fastening end to approach the other branch, the staple being formed by a metal cutout pre-shaped by folding, and is of constant thickness. Intermediate clamping zones of the two branches are cut out such as to form at least two teeth, the edges of which form two complementary clamping surfaces, parallel to the median plane when the staple is folded. The cross-section of clamping surfaces correspond to the cross-section of the metal cutout.

Abstract: Described are passenger seat assemblies having an impact bracket for a support pin. The support pin may be a component of a monitor assembly. The impact bracket includes a body that defines an aperture and a flex member within the aperture. The flex member defines a support region and a travelling region of the aperture. The flex member retains the support pin in the support region responsive to a load that is less than a minimum impact load, and releases the support pin from the support region into the travelling region responsive to a load that is at least the minimum impact load.

Abstract: The balloon includes a pouch formed of a sealed wall delimiting an internal space, and a valve for filling the internal space with a fluid, capable of being occluded after filling the internal space. The pouch delimits a fluid-draining orifice opening into the internal space. The balloon further includes an occluding ball that occludes the draining orifice. The occluding ball can be spherical or polyhedral, and be capable of releasing the draining orifice under the effect of a magnetic field, so as to enable the at least partial drainage of the fluid contained in the internal space. The occluding ball is movable along at least two distinct axes in relation to the pouch.

Abstract: The present disclosure provides description of applicators to implement modular magnetic anastomosis device. In one embodiment the delivery device is a laparoscopic instrument for MISS surgery, in another embodiment the delivery device is endoscopy or colonoscopy instrument for NOTES surgery.

Abstract: The present disclosure provides modular magnetic anastomosis devices that can be implemented in digestive surgery or in any circumstance of anastomosis between adjacent organs or two hollow viscera. The device is minimally invasive and easily and quickly delivered using laparoscopic or endoscopic procedures.

Abstract: The present disclosure provides description of applicators to implement modular magnetic anastomosis device. In one embodiment the delivery device is a laparoscopic instrument for MISS surgery, in another embodiment the delivery device is endoscopy or colonoscopy instrument for NOTES surgery.

Abstract: Described are passenger seat assemblies having an impact bracket for a support pin. The support pin may be a component of a monitor assembly. The impact bracket includes a body that defines an aperture and a flex member within the aperture. The flex member defines a support region and a travelling region of the aperture. The flex member retains the support pin in the support region responsive to a load that is less than a minimum impact load, and releases the support pin from the support region into the travelling region responsive to a load that is at least the minimum impact load.

Abstract: The present disclosure provides modular magnetic anastomosis devices that can be implemented in digestive surgery or in any circumstance of anastomosis between adjacent organs or two hollow viscera. The device is minimally invasive and easily and quickly delivered using laparoscopic or endoscopic procedures.

Abstract: An endoscopic needle holder for handling curved needles includes an articulated assembly including a first gripping jaw forming one piece with a duct and a second gripping jaw actuated by the movable core in transverse displacement; the jaws are made of coaxial cylindrical parts with the mobile core; the first jaw has a plurality of longitudinally extending peripheral teeth; the second jaw consists of a cylindrical part with a plurality of peripheral teeth; and the second jaw is movable with respect to the first jaw by a longitudinal linear displacement between a rest position, where the jaws are spaced to delimit, between the ends of the teeth, an interval at least equal to the section of a needle and a close position where they keep the needle curved.