Abstract: The vertebral body prosthesis includes cephalic and caudal components with a separating setscrew therebetween. The cephalic component includes a generally horizontal member having an upper porous, water-permeable surface complementary shaped to the underside of the adjacent vertebral body, a securement element upstanding along one side for receiving screws to secure the cephalic component to the upper vertebral body and a depending guide element. The lower caudal component includes a generally horizontally disposed member having a porous, water-permeable undersurface complementary shaped to the upper surface of the lower adjacent vertebral body, a depending securement element along one side for receiving screws to secure the caudal component to the lower vertebral body and an upstanding guide element for engaging the depending guide element of the cephalic component to prevent rotation of the components.