Patents by Inventor Juan Jose de Pablo

Juan Jose de Pablo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240402524
    Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.
    Type: Application
    Filed: August 8, 2024
    Publication date: December 5, 2024
    Inventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
  • Patent number: 12085792
    Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.
    Type: Grant
    Filed: June 7, 2023
    Date of Patent: September 10, 2024
    Assignee: The University of Chicago
    Inventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
  • Patent number: 12042519
    Abstract: Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: July 23, 2024
    Assignee: The University of Chicago
    Inventors: Juan Jose de Pablo, Johnny D. Alfaro-Perez, Nader Taheri Qazvini
  • Patent number: 11921393
    Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: March 5, 2024
    Assignee: The University of Chicago
    Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
  • Publication number: 20230400719
    Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.
    Type: Application
    Filed: June 7, 2023
    Publication date: December 14, 2023
    Inventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
  • Patent number: 11779922
    Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: October 10, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
  • Patent number: 11475185
    Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties to the structure adjuster.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: October 18, 2022
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner, Marcos A. Reyes-Martinez, Meng Shen
  • Publication number: 20220288589
    Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
    Type: Application
    Filed: December 20, 2021
    Publication date: September 15, 2022
    Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
  • Publication number: 20220269840
    Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties to the structure adjuster.
    Type: Application
    Filed: April 28, 2022
    Publication date: August 25, 2022
    Inventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner, Marcos A. Reyes-Martinez, Meng Shen
  • Patent number: 11213825
    Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: January 4, 2022
    Assignees: Wisconsin Alumni Research Foundation, University of Leiden, University of Chicago
    Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
  • Publication number: 20210263357
    Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.
    Type: Application
    Filed: March 8, 2021
    Publication date: August 26, 2021
    Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
  • Publication number: 20210145901
    Abstract: Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).
    Type: Application
    Filed: July 13, 2018
    Publication date: May 20, 2021
    Applicants: University of Chicago, University of Chicago
    Inventors: Juan Jose de Pablo, Johnny D. Alfaro-Perez, Nader Taheri Qazvini
  • Patent number: 10969642
    Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 6, 2021
    Assignee: The University of Chicago
    Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
  • Publication number: 20200320235
    Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties 222 to the structure adjuster.
    Type: Application
    Filed: April 1, 2020
    Publication date: October 8, 2020
    Inventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner
  • Publication number: 20200078789
    Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
    Type: Application
    Filed: May 16, 2018
    Publication date: March 12, 2020
    Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk
  • Publication number: 20190054012
    Abstract: Provided herein are polymer-stabilized CaP nanoparticle formulations and related methods of manufacture. In certain embodiments, the methods reliably and selectively form nanoparticles with homogenous size, charge, and morphology. The CaP nanoparticles include calcium ions and phosphate ions with an ionic polymer, thereby forming stable hybrid nanoparticles. The CaP nanoparticle formulations include powders, suspensions and injectable pastes. According to various embodiments, the polymer-stabilized CaP nanoparticles may be polycation-stabilized (CaP/polymer(+) nanoparticles) or polyanion-stabilized (CaP/polymer(-) nanoparticles). The CaP/polymer nanoparticles can be freeze-dried and stored for months with no loss of properties or changes to their morphology.
    Type: Application
    Filed: March 13, 2017
    Publication date: February 21, 2019
    Inventors: Juan Jose de Pablo, Nader Taheri Qazvini, Monirosadat Sadati, Matthew Tirrell
  • Publication number: 20190049767
    Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 14, 2019
    Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
  • Patent number: 9718250
    Abstract: Provided are methods of fabricating thin film structures that involve assembling block copolymer materials in the presence of condensed phase surfaces on both sides of the thin film, at least one of which is a chemically patterned surface configured to direct the assembly of the block copolymer material. According to various embodiments, the other of the condensed phase surfaces can be a chemically homogenous surface or a chemically patterned surface. Also provided are structures, morphologies, and templates formed in the domain structure of block copolymer materials. In certain embodiments, complex 3-D morphologies and related structures not present in bulk block copolymer materials are provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 1, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Paul Franklin Nealey, Huiman Kang, Guoliang Liu, Hiroshi Yoshida, Yashuhiko Tada, Juan Jose De Pablo, Abelardo Ramirez-Hernandez
  • Publication number: 20130189504
    Abstract: Provided are methods of fabricating thin film structures that involve assembling block copolymer materials in the presence of condensed phase surfaces on both sides of the thin film, at least one of which is a chemically patterned surface configured to direct the assembly of the block copolymer material. According to various embodiments, the other of the condensed phase surfaces can be a chemically homogenous surface or a chemically patterned surface. Also provided are structures, morphologies, and templates formed in the domain structure of block copolymer materials. In certain embodiments, complex 3-D morphologies and related structures not present in bulk block copolymer materials are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 25, 2013
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Paul Franklin Nealey, Huiman Kang, Guoliang Liu, Hiroshi Yoshida, Yashuhiko Tada, Juan Jose De Pablo, Abelardo Ramirez-Hernandez
  • Patent number: 7851252
    Abstract: The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some embodiments, the dimensions of the features may be determined by adjusting the grafting density and/or the molecular weight of the brushes. Once the brushes are patterned, the features can be shaped and reshaped with thermal or solvent treatments to achieve the desired profiles. The chemical nature of the polymer brush is thus independent of the patterning process, which allows for optimization of the polymer brush used for specific applications. Applications include masks for pattern transfer techniques such as reactive ion etching.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: December 14, 2010
    Assignee: Wisconsin Alumini Research Foundation
    Inventors: Paul F. Nealey, Tushar S. Jain, Erik W. Edwards, Juan Jose de Pablo