Patents by Inventor Juan Jose de Pablo
Juan Jose de Pablo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240402524Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.Type: ApplicationFiled: August 8, 2024Publication date: December 5, 2024Inventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
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Patent number: 12085792Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.Type: GrantFiled: June 7, 2023Date of Patent: September 10, 2024Assignee: The University of ChicagoInventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
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Patent number: 12042519Abstract: Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).Type: GrantFiled: July 13, 2018Date of Patent: July 23, 2024Assignee: The University of ChicagoInventors: Juan Jose de Pablo, Johnny D. Alfaro-Perez, Nader Taheri Qazvini
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Patent number: 11921393Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.Type: GrantFiled: March 8, 2021Date of Patent: March 5, 2024Assignee: The University of ChicagoInventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
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Publication number: 20230400719Abstract: Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.Type: ApplicationFiled: June 7, 2023Publication date: December 14, 2023Inventors: Juan Jose de Pablo, Gustavo Andres Vasquez Montoya, Tadej Emersic
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Patent number: 11779922Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.Type: GrantFiled: December 20, 2021Date of Patent: October 10, 2023Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
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Patent number: 11475185Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties to the structure adjuster.Type: GrantFiled: April 1, 2020Date of Patent: October 18, 2022Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCEInventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner, Marcos A. Reyes-Martinez, Meng Shen
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Publication number: 20220288589Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.Type: ApplicationFiled: December 20, 2021Publication date: September 15, 2022Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
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Publication number: 20220269840Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties to the structure adjuster.Type: ApplicationFiled: April 28, 2022Publication date: August 25, 2022Inventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner, Marcos A. Reyes-Martinez, Meng Shen
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Patent number: 11213825Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.Type: GrantFiled: May 16, 2018Date of Patent: January 4, 2022Assignees: Wisconsin Alumni Research Foundation, University of Leiden, University of ChicagoInventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
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Publication number: 20210263357Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.Type: ApplicationFiled: March 8, 2021Publication date: August 26, 2021Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
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Publication number: 20210145901Abstract: Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).Type: ApplicationFiled: July 13, 2018Publication date: May 20, 2021Applicants: University of Chicago, University of ChicagoInventors: Juan Jose de Pablo, Johnny D. Alfaro-Perez, Nader Taheri Qazvini
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Patent number: 10969642Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.Type: GrantFiled: July 30, 2018Date of Patent: April 6, 2021Assignee: The University of ChicagoInventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
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Publication number: 20200320235Abstract: An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties 222 to the structure adjuster.Type: ApplicationFiled: April 1, 2020Publication date: October 8, 2020Inventors: Christopher L. Soles, Edwin Pak-Nin Chan, Irmgard Bischofberger, Sidney Robert Nagel, Heinrich Martin Jaeger, Juan Jose de Pablo, Nidhi Pashine, Daniel Robert Reid, Carl Goodrich, Andrea Jo-Wei Liu, Daniel Hexner
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Publication number: 20200078789Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.Type: ApplicationFiled: May 16, 2018Publication date: March 12, 2020Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk
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Publication number: 20190054012Abstract: Provided herein are polymer-stabilized CaP nanoparticle formulations and related methods of manufacture. In certain embodiments, the methods reliably and selectively form nanoparticles with homogenous size, charge, and morphology. The CaP nanoparticles include calcium ions and phosphate ions with an ionic polymer, thereby forming stable hybrid nanoparticles. The CaP nanoparticle formulations include powders, suspensions and injectable pastes. According to various embodiments, the polymer-stabilized CaP nanoparticles may be polycation-stabilized (CaP/polymer(+) nanoparticles) or polyanion-stabilized (CaP/polymer(-) nanoparticles). The CaP/polymer nanoparticles can be freeze-dried and stored for months with no loss of properties or changes to their morphology.Type: ApplicationFiled: March 13, 2017Publication date: February 21, 2019Inventors: Juan Jose de Pablo, Nader Taheri Qazvini, Monirosadat Sadati, Matthew Tirrell
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Publication number: 20190049767Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.Type: ApplicationFiled: July 30, 2018Publication date: February 14, 2019Inventors: Juan Jose de Pablo, Paul Franklin Nealey, Xiao Li, Jose A. Martinez-Gonzalez, Monirosadat Sadati, Rui Zhang, Ye Zhou
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Patent number: 9718250Abstract: Provided are methods of fabricating thin film structures that involve assembling block copolymer materials in the presence of condensed phase surfaces on both sides of the thin film, at least one of which is a chemically patterned surface configured to direct the assembly of the block copolymer material. According to various embodiments, the other of the condensed phase surfaces can be a chemically homogenous surface or a chemically patterned surface. Also provided are structures, morphologies, and templates formed in the domain structure of block copolymer materials. In certain embodiments, complex 3-D morphologies and related structures not present in bulk block copolymer materials are provided.Type: GrantFiled: September 14, 2012Date of Patent: August 1, 2017Assignee: Wisconsin Alumni Research FoundationInventors: Paul Franklin Nealey, Huiman Kang, Guoliang Liu, Hiroshi Yoshida, Yashuhiko Tada, Juan Jose De Pablo, Abelardo Ramirez-Hernandez
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Publication number: 20130189504Abstract: Provided are methods of fabricating thin film structures that involve assembling block copolymer materials in the presence of condensed phase surfaces on both sides of the thin film, at least one of which is a chemically patterned surface configured to direct the assembly of the block copolymer material. According to various embodiments, the other of the condensed phase surfaces can be a chemically homogenous surface or a chemically patterned surface. Also provided are structures, morphologies, and templates formed in the domain structure of block copolymer materials. In certain embodiments, complex 3-D morphologies and related structures not present in bulk block copolymer materials are provided.Type: ApplicationFiled: September 14, 2012Publication date: July 25, 2013Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Paul Franklin Nealey, Huiman Kang, Guoliang Liu, Hiroshi Yoshida, Yashuhiko Tada, Juan Jose De Pablo, Abelardo Ramirez-Hernandez
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Patent number: 7851252Abstract: The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some embodiments, the dimensions of the features may be determined by adjusting the grafting density and/or the molecular weight of the brushes. Once the brushes are patterned, the features can be shaped and reshaped with thermal or solvent treatments to achieve the desired profiles. The chemical nature of the polymer brush is thus independent of the patterning process, which allows for optimization of the polymer brush used for specific applications. Applications include masks for pattern transfer techniques such as reactive ion etching.Type: GrantFiled: February 17, 2009Date of Patent: December 14, 2010Assignee: Wisconsin Alumini Research FoundationInventors: Paul F. Nealey, Tushar S. Jain, Erik W. Edwards, Juan Jose de Pablo