Patents by Inventor Juan L Hancke Orozco

Juan L Hancke Orozco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hippocampus Regeneration And Memory Recovery
    Publication number: 20220409573
    Abstract: We found that Andrographolide binds to GSK-3?: In so doing, andrographolide changies the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-?. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may he used to heal patients with a damaged hippocampus and recover memory loss in such patients.
    Type: Application
    Filed: June 11, 2021
    Publication date: December 29, 2022
    Applicant: INNOBIOSCIENCE, LLC
    Inventors: Nibaldo C. INESTROSA, Juan L. HANCKE OROZCO
  • Treatment of Alzheimer's and Cognitive Impairment With Andrographolides
    Publication number: 20150352075
    Abstract: We found that Andrographolide binds to GSK-3?: In so doing, andrographolide prevents changes in neuropathology in an Alzheimer's model, reducing Amyloid-? peptide levels, changing the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-?. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may be used to treat Alzheimer's disease.
    Type: Application
    Filed: April 21, 2014
    Publication date: December 10, 2015
    Applicant: INNOBIOSCIENCE, LLC
    Inventors: Nibaldo C. INESTROSA, Juan L. HANCKE OROZCO
  • Combination therapy with interferon and andrographolides for Multiple Sclerosis
    Patent number: 9060994
    Abstract: The effectiveness of interferon for treating multiple sclerosis and other demyelinating diseases is synergistically potentiated by concomitant administration of a compound of Formula (I): wherein R1 is H, alkyl or OH, R2 is hydroxyalkyl or alkyl-O-L1, R3 is H or OH, X is C(?CH2), CH(OH), or spirooxirane-2, Z is CH2CH(OH) or C(=0), and R4 is an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: June 23, 2015
    Assignee: Inno Biosciences, S.p.A.
    Inventors: Juan L Hancke Orozco, Rafael Burgos
  • Combination Therapy with Interferon and Andrographolides for Multiple Sclerosis
    Publication number: 20140301981
    Abstract: The effectiveness of interferon for treating multiple sclerosis and other demyelinating diseases is synergistically potentiated by concomitant administration of a compound of Formula (I): wherein R1 is H, alkyl or OH, R2 is hydroxyalkyl or alkyl-O-L1, R3 is H or OH, X is C(?CH2), CH(OH), or spirooxirane-2, Z is CH2CH(OH) or C(=0), and R4 is an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety.
    Type: Application
    Filed: December 19, 2012
    Publication date: October 9, 2014
    Applicant: INNOBIOSCIENCE LLC
    Inventors: Juan L Hancke Orozco, Rafael Burgos