Patents by Inventor Juan Luengo

Juan Luengo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)
    Publication number: 20200291037
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Inventors: Juan Luengo, Hong Lin, Michael Hawkins, Rupa Shetty, Philip Pitis, Gisela Saborit Villarroya
  • Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Patent number: 10711007
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: July 14, 2020
    Assignee: Prelude Therapeutics Incorporated
    Inventors: Juan Luengo, Hong Lin, Michael Hawkins, Rupa Shetty, Philip Pitis, Gisela Saborit Villarroya
  • Spiro-Sulfonamide Derivatives As Inhibitors Of Myeloid Cell Leukemia-1 (MCL-1) Protein
    Publication number: 20200148705
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Inventors: Jincong Zhuo, Raul Leal, Rupa Shetty, Juan Luengo, Andrew Paul Combs
  • Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5)
    Publication number: 20200148692
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: January 16, 2020
    Publication date: May 14, 2020
    Inventors: Hong Lin, Juan Luengo, Rupa Shetty, Michael Hawkins
  • Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Patent number: 10570140
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: February 25, 2020
    Assignee: Prelude Therapeutics Incorporated
    Inventors: Hong Lin, Juan Luengo, Rupa Shetty, Michael Hawkins
  • SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)
    Publication number: 20190284193
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: April 5, 2019
    Publication date: September 19, 2019
    Inventors: Juan Luengo, Hong Lin, Michael Hawkins, Rupa Shetty, Philip Pitus, Gisela Saborit Villarroya
  • Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
    Publication number: 20190048014
    Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
    Type: Application
    Filed: August 9, 2018
    Publication date: February 14, 2019
    Inventors: Hong Lin, Juan Luengo, Rupa Shetty, Michael Hawkins
  • Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors
    Publication number: 20140187545
    Abstract: PI3K? selective compounds having the structure
    Type: Application
    Filed: June 29, 2012
    Publication date: July 3, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Hong Lin, Juan Luengo, Michael Lee Moore, Junya Qu, Ralph A. Rivero, Rosanna Tedesco, Hongyi Yu
  • Pyrimidinone compounds as calcilytics
    Patent number: 7491728
    Abstract: The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: February 17, 2009
    Assignee: SmithKline Beecham Corp.
    Inventors: Irina V. Shcherbakova, Manuel F. Balanddrin, Guangfei Huang, Otto Geoffroy, John Fox, Robert Marquis, Dennis Shinji Yamashita, Juan Luengo, Wenyong Wang
  • Thrombopoietin mimetics
    Publication number: 20080090787
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Application
    Filed: January 8, 2007
    Publication date: April 17, 2008
    Inventors: Kevin Duffy, Connie Erickson-Miller, Daniel Eppley, Julian Jenkins, Juan Luengo, Nannan Liu, Alan Price, Antony Shaw, Sophie Visonneau, Kenneth Wiggall
  • Thrombopoietin mimetics
    Publication number: 20080090996
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Application
    Filed: January 8, 2007
    Publication date: April 17, 2008
    Inventors: Kevin Duffy, Connie Erickson-Miller, Daniel Eppley, Julian Jenkins, Juan Luengo, Nannan Liu, Alan Price, Antony Shaw, Sophie Visonneau, Kenneth Wiggall
  • Thrombopoietin mimetics
    Patent number: 7332481
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kevin J. Duffy, Connie Erickson-Miller, Julian Jenkins, Juan Luengo, Alan T. Price, Antony N. Shaw, Sophie Visonneau, Kenneth Wiggall
  • Reversed Pyrimidinone Compounds as Calcilytics
    Publication number: 20070270446
    Abstract: Calcilytic compounds and methods of preparing them are disclosed. Methods of using the calcilytic compounds are also provided.
    Type: Application
    Filed: October 6, 2005
    Publication date: November 22, 2007
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Robert Marquis Jr, Jae Jeong, Juan Luengo, Dennis Yamashita
  • Calcilytic Compounds
    Publication number: 20070232628
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: May 3, 2005
    Publication date: October 4, 2007
    Inventors: Juan Luengo, Robert Marquis, Ren Xie, Dennis Yamashita
  • Pyrimidinone Compounds As Calcilytics
    Publication number: 20070197555
    Abstract: The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
    Type: Application
    Filed: April 7, 2004
    Publication date: August 23, 2007
    Inventors: Irina Shcherbakova, Manuel Balandrin, Guangfei Huang, Otto Geoffroy, John Fox, Robert Marquis, Dennis Yamashita, Juan Luengo, Wenyong Wang
  • THROMBOPOIETIN MIMETICS
    Publication number: 20070179192
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Application
    Filed: November 9, 2006
    Publication date: August 2, 2007
    Inventors: Kevin Duffy, Connie Erickson-Miller, Julian Jenkins, Juan Luengo, Sophie Visonneau
  • THROMBOPOIETIN MIMETICS
    Publication number: 20070129338
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Application
    Filed: January 5, 2007
    Publication date: June 7, 2007
    Inventors: Kevin DUFFY, Connie Erickson-Miller, Daniel Eppley, Julian Jenkins, Juan Luengo, Nannan Liu, Alan Price, Antony Shaw, Sophie Visonneau, Kenneth Wiggall