Abstract: Various embodiments provide for bistable collapsible tubular mast (Bi-CTM) booms. Various embodiments provide CTM booms that may be bistable in nature, thereby achieving intrinsic benefits bistability may bring. Bistability may be achieved in various embodiments through specific combinations of the thin-shell cross-section geometry and the composite laminate selected for each thin-shell segment. Additionally, in various embodiments, the thin-shell geometry of each boom half may be different. Various embodiments may include combinations of circular, ellipsoidal, or parabolic segments that form each shell.

Abstract: Modulation of microRNAs against myotonic dystrophy type 1 and antagonists of microRNAs therefor. The invention provides the use of inhibitors of microRNAs repressors of MBNL1 and/or MBNL2 genes for the manufacture of a medicinal product for the treatment of myotonic dystrophy 1. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2, thereby alleviating symptoms of the disease, especially when inhibiting repressors that are expressed in the main affected organs: skeletal muscle, heart or organs of the central nervous system. The inhibition of the microRNAs miR-23b-3p and miR-218-5p is preferred. It also provides oligoribonucleotide or oligoribonucleotide analogue antagonists suitable therefor, preferably antagomiRs directed against the microRNAs mentioned with chemical modifications that enhance their interaction with the target, their stability in vivo and their ability to penetrate into the cells and distribute throughout tissues and organs.

Abstract: Various embodiments provide for bistable collapsible tubular mast (Bi-CTM) booms. Various embodiments provide CTM booms that may be bistable in nature, thereby achieving intrinsic benefits bistability may bring. Bistability may be achieved in various embodiments through specific combinations of the thin-shell cross-section geometry and the composite laminate selected for each thin-shell segment. Additionally, in various embodiments, the thin-shell geometry of each boom half may be different. Various embodiments may include combinations of circular, ellipsoidal, or parabolic segments that form each shell.

Abstract: Modulation of microRNAs against myotonic dystrophy type 1 and antagonists of microRNAs therefor. The invention provides the use of inhibitors of microRNAs repressors of MBNL1 and/or MBNL2 genes for the manufacture of a medicinal product for the treatment of myotonic dystrophy 1. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2, thereby alleviating symptoms of the disease, especially when inhibiting repressors that are expressed in the main affected organs: skeletal muscle, heart or organs of the central nervous system. The inhibition of the microRNAs miR-23b-3p and miR-218-5p is preferred. It also provides oligoribonucleotide or oligoribonucleotide analogue antagonists suitable therefor, preferably antagomiRs directed against the microRNAs mentioned with chemical modifications that enhance their interaction with the target, their stability in vivo and their ability to penetrate into the cells and distribute throughout tissues and organs.

Abstract: Various embodiments provide for Corrugated Rollable Tubular Boom (COROTUB) designs. Various embodiments provide a new thin-shell tubular mast design, specifically COROTUB designs, that have unique corrugation features enabled in part by shells only affixed to each other at two respective cross-sectional end web regions.

Abstract: Various embodiments provide for bistable collapsible tubular mast (Bi-CTM) booms. Various embodiments provide CTM booms that may be bistable in nature, thereby achieving intrinsic benefits bistability may bring. Bistability may be achieved in various embodiments through specific combinations of the thin-shell cross-section geometry and the composite laminate selected for each thin-shell segment Additionally, in various embodiments, the thin-shell geometry of each boom half may be different. Various embodiments may include combinations of circular, ellipsoidal, or parabolic segments that form each shell.

Abstract: Various embodiments provide for bistable collapsible tubular mast (Bi-CTM) booms. Various embodiments provide CTM booms that may be bistable in nature, thereby achieving intrinsic benefits bistability may bring. Bistability may be achieved in various embodiments through specific combinations of the thin-shell cross-section geometry and the composite laminate selected for each thin-shell segment Additionally, in various embodiments, the thin-shell geometry of each boom half may be different. Various embodiments may include combinations of circular, ellipsoidal, or parabolic segments that form each shell.

Abstract: Modulation of microRNAs against myotonic dystrophy type 1 and antagonists of microRNAs therefor. The invention provides the use of inhibitors of microRNAs repressors of MBNL1 and/or MBNL2 genes for the manufacture of a medicinal product for the treatment of myotonic dystrophy 1. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2, thereby alleviating symptoms of the disease, especially when inhibiting repressors that are expressed in the main affected organs: skeletal muscle, heart or organs of the central nervous system. The inhibition of the microRNAs miR-23b-3p and miR-218-5p is preferred. It also provides oligoribonucleotide or oligoribonucleotide analogue antagonists suitable therefor, preferably antagomiRs directed against the microRNAs mentioned with chemical modifications that enhance their interaction with the target, their stability in vivo and their ability to penetrate into the cells and distribute throughout tissues and organs.

Abstract: Various embodiments provide rollable and deployable composite booms that may be used in a wide range of applications both for space and terrestrial structural solutions. Various embodiment composite booms may be bistable, i.e. having a stable strain energy minimum in the coiled configuration as well as the in the deployed configuration. In various embodiments, a boom may be fabricated by aligning two independent tape-springs front-to-front encircled by a durable seamless polymer sleeve. The durable seamless polymer sleeve may allow the two tape-springs to slide past each other during the coiling/deployment process so as to reduce, e.g., minimize, shear and its derived problems.

Abstract: Various embodiments provide rollable and deployable composite booms that may be used in a wide range of applications both for space and terrestrial structural solutions. Various embodiment composite booms may be bistable, i.e. having a stable strain energy minimum in the coiled configuration as well as the in the deployed configuration. In various embodiments, a boom may be fabricated by aligning two independent tape-springs front-to-front encircled by a durable seamless polymer sleeve. The durable seamless polymer sleeve may allow the two tape-springs to slide past each other during the coiling/deployment process so as to reduce, e.g., minimize, shear and its derived problems.

Abstract: A process for producing a photovoltaic device having a substrate comprising silicon doped with a first dopant, the process comprising the steps of: a. forming a first layer over a front surface of the substrate, the first layer comprising a second dopant of a conductivity type opposite the first dopant; b. forming a second surface coating over the first layer; c. forming elongate grooves reaching or entering the silicon substrate, d. forming a third layer within the grooves, the layer comprising a third dopant of a conductivity type opposite to the first dopant; e. forming a contact finger system which intersects with the grooves to provide an electrically conducting front contact; and f. forming a second contact.

Abstract: A process for making a photovoltaic cell comprising forming a first layer on a front surface of a semiconductor wafer, the wafer comprising a first dopant and the first layer comprising a dopant of a conductivity type opposite the first dopant; depositing a surface coating on the front surface over the first layer; forming grooves in the front surface after depositing the surface coating thereon; doping the grooves with a dopant having a conductivity opposite the first dopant; treating a back surface of the wafer to remove at least substantially all dopant having a conductivity type opposite the first dopant; forming a back surface field; forming a back electrical contact over the back surface; and adding an electrically conductive material to the grooves to form a front electrical contact.

Abstract: An in-line roller skate having at least one gyroscopic stabilizer mechanically coupled to at least one wheel of the skate for providing stabilization and improved coasting of the skate. The at least one stabilizer is positioned beneath the boot of the skate proximate the user's longitudinal center of gravity and is coupled to one or more of the wheels by a drive belt. An alternate embodiment of the present invention includes a generator driven by one or more of the skate wheels for supplying electrical power to a plurality of lights on the skate.