Patents by Inventor Juan M. Melero-Martin

Juan M. Melero-Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to enhance microvascular engraftment of bioengineered and primary tissues
    Patent number: 11679126
    Abstract: Methods of tissue grafting, and more particularly methods for enhancing tissue graft revascularization, e.g., host engagement of pre-existing graft blood vessels.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 20, 2023
    Assignee: Chldren's Medical Center Corporation
    Inventors: Juan M. Melero-Martin, Ruei-Zeng Lin
  • ROBUST DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO ENDOTHELIAL CELLS USING TRANSCRIPTION FACTOR ETV2
    Publication number: 20200385685
    Abstract: Methods for in vitro differentiation of human pluripotent stem cells into endothelial cells, using a protocol that includes transient expression of exogenous ETS translocation variant 2 (ETV2), and uses of those cells in human therapies, e.g., to treat hemophilia.
    Type: Application
    Filed: May 28, 2020
    Publication date: December 10, 2020
    Inventors: Kai Wang, Ruei-Zeng Lin, Juan M. Melero-Martin
  • Novel Methods to Enhance Microvascular Engraftment of Bioengineered and Primary Tissues
    Publication number: 20190275080
    Abstract: Methods of tissue grafting, and more particularly methods for enhancing tissue graft revascularization, e.g., host engagement of pre-existing graft blood vessels.
    Type: Application
    Filed: November 17, 2017
    Publication date: September 12, 2019
    Inventors: Juan M. Melero-Martin, Ruei-Zeng Lin
  • ENGINEERED VASCULAR ADIPOSE TISSUE
    Publication number: 20130236429
    Abstract: Embodiments of the invention relate to methods, compositions and kits for the in vivo formation of vascularized new adipose tissue in a subject. Combination of endothelial progenitor cells (EPCs) and mesenchymal progenitor cells (MPCs) implanted in vivo in a subject work synergistically to promote the formation vascularized new adipose tissue.
    Type: Application
    Filed: September 22, 2011
    Publication date: September 12, 2013
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Juan M. Melero-Martin, Joyce E. Bischoff
  • METHODS FOR PROMOTING NEOVASCULARIZATION
    Publication number: 20100040584
    Abstract: The success of tissue engineering and therapeutic neovascularization depends on the development of a microvascular network. The present invention provides methods for promoting neovascularization in tissue engineering constructs, tissue repair, and wound healing comprising endothelial and mesenchymal progenitor cells.
    Type: Application
    Filed: December 19, 2007
    Publication date: February 18, 2010
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Juan M. Melero-Martin, Joyce E. Bischoff