Patents by Inventor Juan M Taboas
Juan M Taboas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12285545Abstract: Methods of regenerating vital tooth tissue in situ after endodontic therapy include introducing a hydrogel scaffold into a root canal of a tooth in a patient after native pulp has been removed from the root canal. The hydrogel scaffold may comprise a sponge scaffold, and can be acellular. The hydrogel scaffold can contain chemotactic, angiogenic, neurogenic, and/or immunomodulatory biofactors that cause infiltration of endogenous cells from the patient into the root canal. Alternatively, such biofactors/drugs can be administered to the patient separately from the hydrogel scaffold. The hydrogel scaffold can fill the periapical space of an abscessed root.Type: GrantFiled: March 20, 2019Date of Patent: April 29, 2025Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Herbert L. Ray, Jingming Chen, Patrick Eugene Donnelly, Tyler Swenson
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Publication number: 20230372589Abstract: Disclosed herein implantable material and methods for treatment of growth plate injuries and other purposes. These materials can be particularly useful for treating children whose growth plates are active, and can help encourage proper healing and inhibit unwanted bone formations. Exemplary compositions can comprise poly (ethylene glycol) (“PEG”), gelatin (“GEL”), and heparin (“HEP”). The PEG, GEL, and HEP components can be present in various forms of these materials, such as methacrylated forms, etc. The implanted materials can be anti-osteogenic and/or ant-mineralization, and can help prevent unwanted bone growth in the implanted area, such as boney tethers, which can inhibit desirable growth plate healing and overall bone growth.Type: ApplicationFiled: September 20, 2021Publication date: November 23, 2023Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Jingming Chen
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Publication number: 20230241293Abstract: Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold.Type: ApplicationFiled: February 9, 2023Publication date: August 3, 2023Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Jingming Chen
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Patent number: 11583613Abstract: Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold.Type: GrantFiled: March 3, 2017Date of Patent: February 21, 2023Assignee: University of Pittsburgh—Of The Commonwealth System of Higher EducationInventors: Juan M. Taboas, Jingming Chen
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Publication number: 20210213170Abstract: Biomaterials disclosed herein can comprise a hydrogel comprising PEG, gelatin, and a glycosaminoglycan with sulfated moiety; and chondrogenic, osteogenic, and immunomodulatory cytokines; wherein the biomaterial is capable of potentiating bone regeneration in a compromised wound while reducing inflammatory response. The glycosaminoglycan with sulfated moiety can comprise heparin, heparan sulfate, keratin sulfate, chondroitin sulfate, dermatan sulfate, and/or similar materials. The biomaterial can further comprise mesenchymal stem cells (MSCs), a crosslinking initiator, microparticles and nanoparticles, and or other materials. The biomaterial can be injectable into a wound, or the biomaterial can be loaded in, or further comprise a porous scaffold providing mechanical support for other components of the biomaterial, such that it can be implanted into a wound.Type: ApplicationFiled: June 13, 2019Publication date: July 15, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Alejandro Jose Almarza, Jingming Chen
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Publication number: 20210205500Abstract: Described herein are biomaterials, systems, and methods for guiding regeneration of an epiphyseal growth plate or similar interfacial tissue structures. In one aspect, the disclosed technology can include a biologic material that can comprise one or more of a hydrogel carrier for growth factors and MSCs, chondrogenic and immunomodulatory cytokines, microparticles for prolonged and spatially controlled growth factor delivery; and/or porous scaffold providing mechanical support. The implanted material can be applied via various different modalities depending on the nature of the physeal injury. One modality is an injectable hydrogel and another modality is an implantable hydrogel infused scaffold.Type: ApplicationFiled: March 3, 2017Publication date: July 8, 2021Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Jingming Chen
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Publication number: 20200405916Abstract: Methods of regenerating vital tooth tissue in situ after endodontic therapy include introducing a hydrogel scaffold into a root canal of a tooth in a patient after native pulp has been removed from the root canal. The hydrogel scaffold may comprise a sponge scaffold, and can be acellular. The hydrogel scaffold can contain chemotactic, angiogenic, neurogenic, and/or immunomodulatory biofactors that cause infiltration of endogenous cells from the patient into the root canal. Alternatively, such biofactors/drugs can be administered to the patient separately from the hydrogel scaffold. The hydrogel scaffold can fill the periapical space of an abscessed root.Type: ApplicationFiled: March 20, 2019Publication date: December 31, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Juan M. Taboas, Herbert L. Ray, Jingming Chen, Patrick Eugene Donnelly, Tyler Swenson
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Patent number: 8709793Abstract: A bioreactor device, and a method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 ?L) of local medium volume but sample sizes of about 100 ?L or greater. The bioreactor device includes a bioreactor chamber for containing a sample, where sample growth in response to mechanical, electrical, and biofactor stimulation is monitored through one or more optical ports. Embedded sensors are provided for measuring fluid pressure, pH, temperature, and oxygen tension. The bioreactor device can receive different types of mechanical loadings, including fluid shear, hydrostatic pressure, matrix compression, and clinorotation.Type: GrantFiled: July 20, 2006Date of Patent: April 29, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Juan M. Taboas, Rocky S. Tuan, Steven D. Hudson
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Publication number: 20090215104Abstract: A bioreactor device, and a method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 ?L) of local medium volume but sample sizes of about 100 ?L or greater. The bioreactor device includes a bioreactor chamber for containing a sample, where sample growth in response to mechanical, electrical, and biofactor stimulation is monitored through one or more optical ports. Embedded sensors are provided for measuring fluid pressure, pH, temperature, and oxygen tension. The bioreactor device can receive different types of mechanical loadings, including fluid shear, hydrostatic pressure, matrix compression, and clinorotation.Type: ApplicationFiled: July 20, 2006Publication date: August 27, 2009Applicant: Government of the US, as represented by the Secre- tary, Department of Health and Human ServicesInventors: Juan M. Taboas, Rocky S. Tuan, Steven D. Hudson
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Patent number: 7174282Abstract: A design methodology is provided for creating biomaterial scaffolds optimized for in vivo function with any 3D anatomic shape. The method creates all designs using voxel based design techniques. It also provides for optimization of implant and scaffold microstructure to best match functional and biofactor delivery (including cells, genes and proteins) requirements. The voxel based design techniques readily allow combination of any scaffold or implant microstructure database with any complex 3D anatomic shape created by CT or MRI scanners. These designs can be readily converted to formats for layered manufacturing or casting.Type: GrantFiled: June 24, 2002Date of Patent: February 6, 2007Inventors: Scott J Hollister, Gabriel Tien-Min Chu, Juan M Taboas
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Publication number: 20030069718Abstract: A design methodology is provided for creating biomaterial scaffolds optimized for in vivo function with any 3D anatomic shape. The method creates all designs using voxel based design techniques. It also provides for optimization of implant and scaffold microstructure to best match functional and biofactor delivery (including cells, genes and proteins) requirements. The voxel based design techniques readily allow combination of any scaffold or implant microstructure database with any complex 3D anatomic shape created by CT or MRI scanners. These designs can be readily converted to formats for layered manufacturing or casting.Type: ApplicationFiled: June 24, 2002Publication date: April 10, 2003Inventors: Scott J. Hollister, Gabriel Tien-Min Chu, Juan M. Taboas
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Publication number: 20030006534Abstract: An indirect solid free form scaffold manufacturing technique is provided. More particularly, the present invention provides a set of molds, casting methods, mold removals, and surface modification techniques that are compatible with image-based design methods and with solvent, melt, and slurry casting of polymers and ceramics.Type: ApplicationFiled: June 24, 2002Publication date: January 9, 2003Inventors: Juan M. Taboas, Rachel D. Maddox, Paul H. Krebsbach, Scott J. Hollister, Tien-Min Gabriel Chu