Abstract: The present disclosure provides a recombinant humanized monoclonal antibody against programmed cell death receptor-1 (PD-1) or an antigen-binding fragment thereof, which can be used in tumor or cancer immunotherapy. The disclosure also provides nucleic acid sequences encoding said antibody or antigen-binding fragment thereof, vectors containing said nucleic acid sequences, pharmaceutical compositions and kits.

Abstract: An electrolytic solution includes a compound containing a —CN functional group and a compound containing a silicon functional group. M is C or Si. R11, R12, and R13 are each independently selected from a substituted or non-substituted C1-C12 alkylene group, a substituted or non-substituted C2-C12 alkenylene group, an O—R group, an R0—S—R group or an R0—O—R group, R0 and R are each independently selected from a substituted or non-substituted C1-C6 alkylene group. n is 0 or 1. R14 is H, fluorine, a cyano group, a substituted or non-substituted C1-C12 alkyl group, a substituted or non-substituted C2-C12 alkenyl group, an O—R1 group, an R0—S—R1 group, or an R0—O—R1 group. R0 is a substituted or non-substituted C1-C6 alkylene group, and R1 is a substituted or non-substituted C1-C6 alkyl group.

Abstract: The present application relates to an electrolyte and an electrochemical device including the same. The electrolyte includes a diboronic acid compound and a nitrile compound, so that the storage performance and cycle performance of the electrochemical device using the electrolyte can be remarkably improved.

Abstract: The present application relates to an electrolytic solution and an electrochemical device using same. The electrolytic solution of the present application comprises a compound containing a —CN functional group and a compound containing a P—O bond. By introducing the compound containing a —CN functional group and the compound containing a P—O bond into the electrolytic solution, an active material can be better protected, thereby effectively improving floatation performance and nailing performance of a battery, and cycle impedance of the battery.

Abstract: A rail apparatus, a laser apparatus, and a laser machining device are provided in the present disclosure. The rail apparatus includes a rail frame assembly and a mounting assembly. The rail frame assembly includes a rail frame and a guide shaft fixed to the rail frame. The mounting assembly includes a mounting base and a pulley. The pulley defines a sliding groove. The sliding groove is slidably connected with the guide shaft. The laser apparatus includes a base, a laser, and a focusing member. The laser is disposed on the base and is configured to emit a laser light. The focusing member is movably disposed on the base and has a focusing end. The laser apparatus is operable in a retracting state and an extending state. The laser machining device includes the rail apparatus and the laser apparatus.

Abstract: The present application relates to an electrolyte and an electrochemical device. The electrolyte comprises a cesium salt and a nitrile compound. The electrolyte provided in the present application improves rapid charge-discharge performance and cycle performance of a lithium-ion battery while improving the problem of battery gassing during continuous charge.

Abstract: An electrolytic solution includes a compound containing a —CN functional group and a compound containing a silicon functional group. M is C or Si. R11, R12, and R13 are each independently selected from a substituted or non-substituted C1-C12 alkylene group, a substituted or non-substituted C2-C12 alkenylene group, an O—R group, an R0—S—R group or an R0—O—R group, R0 and R are each independently selected from a substituted or non-substituted C1-C6 alkylene group. n is 0 or 1. R14 is H, fluorine, a cyano group, a substituted or non-substituted C1-C12 alkyl group, a substituted or non-substituted C2-C12 alkenyl group, an O—R1 group, an R0—S—R1 group, or an R0—O—R1 group. R0 is a substituted or non-substituted C1-C6 alkylene group, and R1 is a substituted or non-substituted C1-C6 alkyl group.

Abstract: The present disclosure provides a recombinant humanized monoclonal antibody against programmed cell death receptor-1 (PD-1) or an antigen-binding fragment thereof, which can be used in tumor or cancer immunotherapy. The disclosure also provides nucleic acid sequences encoding said antibody or antigen-binding fragment thereof, vectors containing said nucleic acid sequences, pharmaceutical compositions and kits.

Abstract: The present application relates to an electrolyte and an electrochemical device. The electrolyte includes an organic solvent, an additive and a lithium salt, the additive including a cyclic borate and a nitrile compound. The electrolyte of the present application has good stability at a high working voltage. In another embodiment of the present application, the combination of the electrolyte and an anode having a high compacted density provides a high energy density for the electrochemical device, and improves the storage, floating charge and dynamicperformance of the electrochemical device.

Abstract: The present application relates to an electrolytic solution and an electrochemical device using same. The electrolytic solution of the present application comprises a compound containing a —CN functional group and a compound containing a P—O bond. By introducing the compound containing a —CN functional group and the compound containing a P—O bond into the electrolytic solution, an active material can be better protected, thereby effectively improving floatation performance and nailing performance of a battery, and cycle impedance of the battery.

Abstract: The present application relates to an electrolyte and an electrochemical device including the same. The electrolyte includes a diboronic acid compound and a nitrile compound, so that the storage performance and cycle performance of the electrochemical device using the electrolyte can be remarkably improved.

Abstract: The present application relates to an electrolyte and an electrochemical device. The electrolyte comprises a cesium salt and a nitrile compound. The electrolyte provided in the present application improves rapid charge-discharge performance and cycle performance of a lithium-ion battery while improving the problem of battery gassing during continuous charge.

Abstract: The present application relates to an electrolyte and an electrochemical device. The electrolyte includes an organic solvent, an additive and a lithium salt, the additive including a cyclic borate and a nitrile compound. The electrolyte of the present application has good stability at a high working voltage. In another embodiment of the present application, the combination of the electrolyte and an anode having a high compacted density provides a high energy density for the electrochemical device, and improves the storage, floating charge and dynamicperformance of the electrochemical device.

Abstract: The present application provides an electrolyte and a lithium ion battery. The electrolyte comprises an additive and a solvent, wherein the additive comprises a cyclic borate ester, and the solvent comprises a fluorocarbonate compound. The present application greatly improves the high temperature performance and safety performance of a lithium ion battery at a high voltage by using a cyclic borate ester as a high temperature additive and in combination with a fluorocarbonate compound.

Abstract: The present application provides an electrolytic solution, comprising: a carbonate compound of the formula (I), wherein R1, R2, R3 and R4 are each independently selected from hydrogen or halogen, and at least one of R1, R2, R3 and R4 is halogen; a carbonate compound of the formula (II), wherein R5 and R6 are each independently selected from hydrogen, halogen, (C1-C10)alkyl, (C1-C10)haloalkyl, (C1-C10)alkoxy or (C1-C10)haloalkoxy, and at least one of R5 and R6 is (C1-C10)haloalkyl or (C1-C10)haloalkoxy; and a nitrile compound, the nitrile compound being selected from the group consisting of a dinitrile compound of the formula (III), a dinitrile compound of the formula (IV), a trinitrile compound of the formula (V), and a combination thereof: where x is a positive integer from 1 to 10, and y is a positive integer from 2 to 10.

Abstract: Examples of the present application provide an electrolyte comprising a lithium salt, an organic solvent, and an additive, wherein the additive comprises a nitrile compound, a fluorophosphazene, and a fluoroether. By using the electrolyte comprising a nitrile compound, a fluorophosphazene, a fluoroether, the thermal stability of the electrolyte itself and the positive electrode material may be significantly improved through the synergistic effect of above three and the safety of the lithium-ion battery is greatly enhanced when the electrolyte is applied to the lithium-ion battery. In addition, by adding a cyclic carbonate with carbon-carbon double bond and fluorocyclic carbonate and by controlling the mass percentage of nitrile compound, fluorophosphazene, fluoroether in electrolyte, significant improvements in the safety of lithium-ion batteries may be achieved without significantly degrading the cycling performance of the lithium-ion battery.

Abstract: The invention relates to a preparation method of green nylon poly butyrolactams, the biological materials of GABA in vacuum under the condition of high temperature melt decomposition and purified butyrolactams, then by vacuum polymerization of green nylon poly butyrolactams. Compared with the prior art, the invention is prepared by biological method for the synthesis of a wide range of sources, to solve the problem of raw material supply PA4 for mass production, reduce the cost of reaction, and the reaction condition is simple, easy to implement simplified synthesis steps, from the laboratory to the transformation of industrial production.

Abstract: The invention relates to a preparation method of green nylon poly butyrolactams, the biological materials of GABA in vacuum under the condition of high temperature melt decomposition and purified butyrolactams, then by vacuum polymerization of green nylon poly butyrolactams. Compared with the prior art, the invention is prepared by biological method for the synthesis of a wide range of sources, to solve the problem of raw material supply PA4 for mass production, reduce the cost of reaction, and the reaction condition is simple, easy to implement simplified synthesis steps, from the laboratory to the transformation of industrial production.

Abstract: A method for detecting Bacillus Anthracis comprises steps: obtaining DNA of a sample; respectively mixing the DNA with Primer Sets pXO1, pXO2 and PL3 to form a first reactant mixture, a second reactant mixture and a third reactant mixture, wherein the Primer Sets pXO1, pXO2 and PL3 are respectively sequences specially designed for pXO1, pXO2 and PL3; respectively undertaking PCRs of the first reactant mixture, the second reactant mixture and the third reactant mixture; and detecting whether the sample contains sequences of pXO1, pXO2 and PL3 simultaneously to determine whether the sample contains Bacillus Anthracis. The present invention detects whether the sample contains pXO1, pXO2 and PL3 simultaneously to determine whether the sample contains Bacillus Anthracis and further uses specified primer sets to undertake PCRs and increase the sensitivity and specificity of detection. Thereby is increased the speed and accuracy of detection.

Abstract: Techniques for scanning an object that does not fit upon a scan surface of a scanner and requires a non-linear scanning path are described. In one embodiment, a pair of optical navigation sensors and an image sensor (e.g., CIS) are used to determine coordinates and an angle of a scanning object. By acquiring the coordinates of optical navigation sensors with respect to the image sensor after each relative movement between the image sensor and the scanning object, coordinates of pixel points on the image sensor can be readily determined as long as there is a predefined geometry between the optical navigation sensors and the image sensor. In addition, scanned image data can be modified, enhanced or corrected in scanning or in memory.