Abstract: This invention relates to a recombinant single chain chorionic gonadotropin polypeptide, having an amino acid sequence encoding the beta chain and the alpha chain of the equine chorionic gonadotropin linked to one or more sequences that include glycosylation sites, which results in excellent in vitro and in vivo activity. The DNA molecules that encode the recombinant polypeptide are also taught, an expression vector comprising these DNA molecules, compositions comprising the recombinant protein and methods for preparing them are also disclosed.

Abstract: A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.

Abstract: A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.