Patents by Inventor Juan Marugan
Juan Marugan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240002350Abstract: Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions.Type: ApplicationFiled: November 17, 2021Publication date: January 4, 2024Inventors: Sally Ellen MORGANROTH, Valerian KAGAN, Jinming ZHAO, Ganesha RAI, Hulya BAYIR, Yulia TYURINA, Haider DAR, Tamil ANTHONYMUTHU, Joel GREENBERGER, Michael EPPERLY, Diane LUCI, Juan MARUGAN, Anton SIMEONOV, Alexey V. ZAKHAROV, Adam YASGAR, Andrew AMOSCATO
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Publication number: 20230279007Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: ApplicationFiled: April 7, 2023Publication date: September 7, 2023Inventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 11702417Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: GrantFiled: May 18, 2020Date of Patent: July 18, 2023Assignees: The General Hospital Corporation, The United States Of America, as represented by the secretary, Department of Health and Human ServicesInventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Publication number: 20230158025Abstract: Described herein are compounds that inhibit galactokinase (GALK) and other kinases and methods for producing the same. Also described are methods for using Structure-Activity Relationships (SAR) to develop compounds with enhanced activity.Type: ApplicationFiled: April 22, 2021Publication date: May 25, 2023Inventors: Li Lui, Ya-qin Zhang, Surendra Karavadhi, Juan Marugan, Matthew Hall, Min Shen, Samarjit Patnaik, Kent Lai, Manshu Tang, Francis G. Whitby, Christopher P. Hill, Bijina Balakrishna
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Publication number: 20230000857Abstract: The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for prevention and treatment of human cytomegalovirus (CMV). In one embodiment, a pharmaceutical composition comprises (a) emetine or a derivative thereof; (b) a human cytomegalovirus (HCMV) drug; and (c) a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical composition further comprises an adjuvant. In a specific embodiment, the HCMV drug is ganciclovir. In such embodiments, emetine is present at about 1/10 to about 1/100 the normal dosage for amebiasis.Type: ApplicationFiled: February 11, 2022Publication date: January 5, 2023Inventors: Ravit Boger, Marc Ferrer, Juan Marugan, Andres Dulcey Garcia, Noel Terrence Southall, Xin Hu
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Patent number: 11253511Abstract: The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for prevention and treatment of human cytomegalovirus (CMV). In one embodiment, a pharmaceutical composition comprises (a) emetine or a derivative thereof; (b) a human cytomegalovirus (HCMV) drug; and (c) a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical composition further comprises an adjuvant. In a specific embodiment, the HCMV drug is ganciclovir. In such embodiments, emetine is present at about 1/10 to about 1/100 the normal dosage for amebiasis.Type: GrantFiled: January 4, 2017Date of Patent: February 22, 2022Assignees: The Johns Hopkins University, THE UNITED STATES OF AMERICA, as represented by thInventors: Ravit Boger, Marc Ferrer, Juan Marugan, Andres Dulcey Garcia, Noel Terrence Southall, Xin Hu
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Publication number: 20200283441Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: ApplicationFiled: May 18, 2020Publication date: September 10, 2020Inventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 10676475Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: GrantFiled: January 15, 2016Date of Patent: June 9, 2020Assignees: The General Hospital Corporation, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 10620187Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perfluorinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: GrantFiled: March 23, 2018Date of Patent: April 14, 2020Assignees: University of Maryland, College Park, Children's National Medical CenterInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Patent number: 10392646Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.Type: GrantFiled: October 17, 2013Date of Patent: August 27, 2019Assignees: University of Maryland, College Park, Children's National Medical Center, The United States of America, as Represented by The Secretary, Department of Health and Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Publication number: 20190022083Abstract: The present invention relates to the field of virology. More specifically, the present invention provides methods and CN compositions useful for prevention and treatment of human cytomegalovirus (CMV). In one embodiment, a pharmaceutical composition comprises (a) emetine or a derivative thereof; (b) a human cytomegalovirus (HCMV) drug; and (c) a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical composition further comprises an adjuvant. In a specific embodiment, the HCMV drug is ganciclovir. In such embodiments, emetine is present at about 1/10 to about 1/100 the normal dosage for amebiasis.Type: ApplicationFiled: January 4, 2017Publication date: January 24, 2019Inventors: Ravit Boger, Marc Ferrer, Juan Marugan, Andres Dulcey Garcia, Noel Terrence Southall, Xin Hu
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Publication number: 20180284099Abstract: The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: ApplicationFiled: March 23, 2018Publication date: October 4, 2018Applicants: University of Maryland, College Park, Children's National Medical Center, The United States Of America, As Represented By The Secretary, Dept. Of Health And Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Publication number: 20180118748Abstract: Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.Type: ApplicationFiled: January 15, 2016Publication date: May 3, 2018Inventors: Susan A. Slaugenhaupt, Graham Johnson, William D. Paquette, Wei Zhang, Juan Marugan
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Patent number: 9952199Abstract: The present disclosure relates to a bio-sensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkaline buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: GrantFiled: September 2, 2014Date of Patent: April 24, 2018Assignees: University of Maryland, College Park, Children's National Medical Center, The United States of America, As Represented By The Secretary, Dept. Of Health And Human ServicesInventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Patent number: 9446048Abstract: A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBF? and RUNX1 binding in the subject, thereby treating the CBF leukemia.Type: GrantFiled: March 15, 2012Date of Patent: September 20, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Pu Liu, Wei Zheng, Juan Marugan, Noel T. Southall, Lea Cunningham
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Publication number: 20160231310Abstract: The present disclosure relates to a bio-sensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkaline buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.Type: ApplicationFiled: September 2, 2014Publication date: August 11, 2016Inventors: Omar Bilal AYYUB, Adam Michael BEHRENS, Peter KOFINAS, Marshall Lynn SUMMAR, Juan Manuel CABRERA-LUQUE, Gary CUNNINGHAM, Anton SIMEONOV, Juan MARUGAN
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Publication number: 20160168613Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.Type: ApplicationFiled: October 17, 2013Publication date: June 16, 2016Inventors: Omar Bilal Ayyub, Adam Michael Behrens, Peter Kofinas, Marshall Lynn Summar, Juan Manuel Cabrera-Luque, Gary Cunningham, Anton Simeonov, Juan Marugan
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Publication number: 20140155420Abstract: The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.Type: ApplicationFiled: January 10, 2012Publication date: June 5, 2014Applicants: The Regents of the University of Colorado, a body corporate, Department of Health and Human ServicesInventors: Rui Zhao, Heide L. Ford, Noel Southall, Erika Englund, Samarjit Patnaik, Marc Ferrer, Wei Zheng, Seameen Dehdashti, Juan Marugan
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Publication number: 20140004082Abstract: A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBF? and RUNX1 binding in the subject, thereby treating the CBF leukemia.Type: ApplicationFiled: March 15, 2012Publication date: January 2, 2014Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Pu Liu, Wei Zheng, Juan Marugan, Noel T. Southall, Lea Cunningham
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Publication number: 20070219233Abstract: The present invention relates to novel substituted indole compounds that are antagonists of alpha V (?v) integrins, for example ?v?3 and ?v?5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by ?v?3 and ?v?5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.Type: ApplicationFiled: May 31, 2007Publication date: September 20, 2007Inventors: Tianbo Lu, Bruce Tomczuk, Louis LaFrance, Thomas Markotan, Juan Marugan Sanchez, Victor Marder, David U'Prichard, Beth Anaclerio, Zihong Guo, Wenzi Pan, Kristi Leonard