Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

Abstract: The disclosure is generally directed to systems and methods for assisting a physically handicapped individual to obtain a ride in an autonomous vehicle. In one exemplary embodiment, a physically handicapped individual can use a helper application installed in a smartphone to initiate a request for an autonomous vehicle. Upon receiving the request, the helper application determines a first set of location coordinates of the physically handicapped individual and a second set of location coordinates of an autonomous vehicle that is available to provide the ride. The helper application may use the first set and/or the second set of location coordinates to identify a parking spot for the autonomous vehicle. The smartphone then transmits to the autonomous vehicle, a first set of instructions directing the autonomous vehicle to drive to the parking spot, and a second set of instructions to the physically handicapped individual to assist in moving to the parking spot.

Abstract: The disclosure is generally directed to systems and methods for assisting a physically handicapped individual to obtain a ride in an autonomous vehicle. In one exemplary embodiment, a physically handicapped individual can use a helper application installed in a smartphone to initiate a request for an autonomous vehicle. Upon receiving the request, the helper application determines a first set of location coordinates of the physically handicapped individual and a second set of location coordinates of an autonomous vehicle that is available to provide the ride. The helper application may use the first set and/or the second set of location coordinates to identify a parking spot for the autonomous vehicle. The smartphone then transmits to the autonomous vehicle, a first set of instructions directing the autonomous vehicle to drive to the parking spot, and a second set of instructions to the physically handicapped individual to assist in moving to the parking spot.

Abstract: A turbine blade for a gas turbine engine. The turbine blade having a plurality of cooling holes defined therein, at least some of the plurality of cooling holes being located on a suction side of an airfoil of the turbine blade and in fluid communication with an internal cavity of the turbine blade; and wherein the at least some of the plurality of cooling holes are located in the airfoil according to the coordinates of Tables 1 and/or 2.

Abstract: Disclosed herein is a turbine blade for a gas turbine engine. The turbine blade having a plurality of cooling holes defined therein, at least some of the plurality of cooling holes being located on a suction side of an airfoil of the turbine blade and in fluid communication with an internal cavity of the turbine blade; and wherein the at least some of the plurality of cooling holes are located in the airfoil according to the coordinates of Tables 1 and/or 2.