Abstract: The present disclosure provides for, among other things, methods and systems for detecting, diagnosing, predicting, monitoring, screening for, staging, and/or providing survival prognosis for advanced adenoma and/or colorectal cancer using DNA methylation markers. For example, described herein are DNA methylation markers that enable categorization and prognosis evaluation of advanced adenoma (AA) and/or colorectal cancer (CRC) patients with high accuracy from human biospecimens.

Abstract: The luggage case construction has a first open sided shell over which a cover is removably secured. The shell includes bottom, top and two end walls interconnected by a rectangular back wall. An elongated frame member extends continuously along the inner top wall surface, both end walls and for a distance inwardly of the end walls onto the bottom wall. The frame is centrally located within the shell and includes a pair of parallel rib-like elements integrally related by a wall portion via which it is riveted to the luggage case shell. At each of the corners of the luggage case sheel and in the central portion immediately under the handle of the top wall there are provided sheet-like elements between the channel and the luggage case walls. The sheet-like members extend transversely of the luggage case an amount equal to the total case width, such that when the cover is closed over the shell and the secured in place, the sheet-like member establishes a firm case width.