Patents by Inventor Juan Ramon Rodriguez Fernandez-Alba

Juan Ramon Rodriguez Fernandez-Alba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SEALANT COMPOSITIONS
    Publication number: 20160082145
    Abstract: The invention provides a combination comprising thrombin, fibrinogen, and lipidated tissue factor, as well as sealant compositions comprising thereof, and their use as a sealant agent as well as in the treatment of hemorrhages. The combination and compositions of the invention shows improved hemostatic properties and, at the same time, the quality of the clot formed is so consistent that the sealant efficiency is improved over those sealant compositions of the prior art.
    Type: Application
    Filed: December 20, 2013
    Publication date: March 24, 2016
    Applicant: THROMBOTARGETS EUROPE, S.L.
    Inventors: Juan Ramon RODRÍGUEZ FERNÁNDEZ - ALBA, Jesús MURAT MORENO
  • HEMOSTATIC COMPOSITIONS
    Publication number: 20160000863
    Abstract: The invention provides a composition comprising a combination of lipidated tissue factor and thrombin, wherein the amount of thrombin is comprised from 1 to 30 IU per gram of composition, and the amount of lipidated tissue factor is comprised from 5 to 150 ng per gram of composition. The present invention also provides pharmaceutical or veterinary compositions as well as hemostatic compositions. The compositions of the invention are useful in the treatment of hemorrhages.
    Type: Application
    Filed: January 23, 2014
    Publication date: January 7, 2016
    Applicant: THROMBOTARGETS EUROPE, S.L
    Inventors: Juan Ramon RODRÍGUEZ FERNÁNDEZ-ALBA, Jesús MURAT MORENO
  • Microvesicles derived from recombinant yeast having haemostatic activities and uses thereof
    Patent number: 8759294
    Abstract: Tissue factor-bearing yeast derived microvesicles comprising a yeast membrane and a tissue factor protein, or a fragment thereof, or a tissue factor protein or a fragment thereof fused to another peptide as a fusion protein having pro-coagulant activity are disclosed. Said products can be used as pro-coagulant agents in the treatment of hemorrhages in a subject.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: June 24, 2014
    Assignee: Thrombotargets Europe, S.L.
    Inventors: Francisco Javier Pedrño Egea, Luis Ignacio Caveda Catasus, Juan Ramón Rodríguez Fernández-Alba
  • Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof
    Patent number: 8735351
    Abstract: The invention relates to a method for improving the procoagulant properties of TF expressed in eukaryotic cells by contacting microvesicles derived from said eukaryotic cells with a negatively-charged phospholipid such as phosphatidylserine. The invention also relates to microvesicles obtained using said method as well as to the uses thereof as procoagulant agents, for wound healing and for promoting angiogenesis.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: May 27, 2014
    Assignee: Thrombotargets Europe, S.L.
    Inventors: Jesús Murat Moreno, Juan Ramon Rodriguez Fernández-Alba
  • PHOSPHOLIPID-ENRICHED VESICLES BEARING TISSUE FACTOR HAVING HAEMOSTATIC ACTIVITIES AND USES THEREOF
    Publication number: 20130059782
    Abstract: The invention relates to a method for improving the procoagulant properties of TF expressed in eukaryotic cells by contacting microvesicles derived from said eukaryotic cells with a negatively-charged phospholipid such as phosphatidylserine. The invention also relates to microvesicles obtained using said method as well as to the uses thereof as procoagulant agents, for wound healing and for promoting angiogenesis.
    Type: Application
    Filed: April 19, 2011
    Publication date: March 7, 2013
    Applicant: THROMBOTARGETS EUROPE, S.L.
    Inventors: Jesús Murat Moreno, Juan Ramon Rodríguez Fernández - Alba
  • MICROVESICLES DERIVED FROM RECOMBINANT YEAST HAVING HAEMOSTATIC ACTIVITIES AND USES THEREOF
    Publication number: 20100047335
    Abstract: Tissue factor-bearing yeast derived microvesicles comprising a yeast membrane and a tissue factor protein, or a fragment thereof, or a tissue factor protein or a fragment thereof fused to another peptide as a fusion protein having pro-coagulant activity are disclosed. Said products can be used as pro-coagulant agents in the treatment of hemorrhages in a subject.
    Type: Application
    Filed: December 28, 2007
    Publication date: February 25, 2010
    Applicant: THROMBOTARGETS EUROPE , SL
    Inventors: Javier Pedreno Egea, Luis Caveda Catasus, Juan Ramon Rodriguez-Fernandez-Alba
  • Empty capsids (vlps(-vp4)) of the infectious bursal disease virus (ibdv), obtainment process and applications
    Publication number: 20090208528
    Abstract: The empty capsids of the infectious bursal disease virus (IBDV), VLP(?VP4), are characterized in that they are constituted only by assembly of IBDV pVP2 proteins and IBDV VP3 proteins. Said capsids have immunogenic activity and can be used in the manufacture of vaccines for protecting animals from the infection caused by IBDV, as well as in the manufacture of gene therapy vectors.
    Type: Application
    Filed: January 21, 2005
    Publication date: August 20, 2009
    Inventors: Jose Francisco Rodriguez Aguirre, Jose Ruiz Caston, Maria Dolores Gonzalez de Llano, Ana Maria Ona Blanco, Fernando Abaitua Elustondo, Daniel Luque Buzo, Juan Ramon Rodriguez Fernandez-Alba
  • Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
    Patent number: 7476387
    Abstract: The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound to a region B consisting of a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful for prophylactic, therapeutic or diagnostic purposes.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: January 13, 2009
    Assignee: Chimera Pharma S.L.U.
    Inventors: Jose Francisco Rodriguez Aguirre, Jose Ruiz Caston, Irene Saugar Gomez, Ana Maria Ona Blanco, Juan Ramon Rodriguez Fernandez-Alba
  • Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
    Publication number: 20070015243
    Abstract: The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound to a region B consisting of a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: May 11, 2006
    Publication date: January 18, 2007
    Inventors: Jose Francisco Rodriguez Aguirre, Jose Caston, Irene Gomez, Ana Maria Blanco, Juan Ramon Rodriguez Fernandez-Alba