Abstract: The present invention provides IP4-4,6 substituted derivatives, their methods of synthesis and their uses. In some aspects, the IP4-4,6 derivative is a compound of formula I wherein R1, R3, R7, and R11 are OPO32?, and R5 and R9 are selected from the group consisting of —O(Alkyl)nX, —O(Alkyl)yCy(Alkyl2)y-Z, —O(Alkyl)yA(Alkyl)y-Z?, and their thiophosphate analogs. Also provided are methods, pharmaceutical compositions and formulations, methods of use, articles of manufacture, and kits for the treatment of diseases and conditions such as pathological crystallization-related diseases and conditions.

Abstract: A splint device for robotically-guided surgery includes elongate co-extending first and second splint portions each defining spaced-apart relief holes between first and second ends. A first separability provision is disposed between and extends along the first and second splint portions. A tracking portion is engaged with and extends outwardly from the first or second splint portion and extending outwardly therefrom, and has a kinematic mount engaged therewith. A second separability provision extending between one of the relief holes of the first splint portion and one of the relief holes of the second splint portion, wherein the second separability provision is arranged to be severable so as to facilitate adjustability of a length of the first and second splint portions and the first separability provision. The splint device can include a tool calibration provision or a fiducial marker element disposed in a predetermined disposition relative to the kinematic mount.

Abstract: A splint device for guided robotic surgery, includes an arcuate splint body having first and second ends and opposing concave and convex surfaces. The splint body defines a plurality of holes spaced apart between the first and second ends, with each hole extending between the concave and convex surfaces. A tracking portion is engaged with the convex surface of the splint body between the first and second ends such that at least one of the holes is disposed between the tracking portion and each of the first and second ends. The tracking portion extends outwardly from the convex surface and has a kinematic mount engaged therewith.

Abstract: A plate for fracture fixation is provided including a plurality of individually adjustable heads and various features to achieve: a.) superior fixation of the plate to osteoporotic diaphyseal bone; b.) improved visualization of the fracture line; c.) intraoperative adjustability to achieve better contact of the plate and the bone; d.) reduced risk of post-surgery tendon rupture; d.) improved fixation of small volar marginal fragments and, e.) improved targeting and fixing of particular fractured bone fragments.

Abstract: A hook plate for use in conjunction with a fracture fixation plate, said fracture fixation plate including a bone contacting surface and an opposite surface, said hook plate comprising a substantially rigid plate having a first portion and a second portion; the first portion adapted for slidable engagement with, said opposite surface of said fracture fixation plate; the second portion configured to wrap around an edge of said fracture fixation plate to engage with a bone fragment and reduce a fracture; the first portion being substantially flat and defining a first portion plane; the second portion having at least two projections which curve downward to a position below the first portion plane and terminate in hook ends adapted to engage with said bone fragment; the first portion including a slot that transects said hook plate from a surface of said hook plate that faces the fracture fixation plate to an opposing surface of said hook plate for engagement with a fastener on said opposite surface of said fractu

Abstract: A splint device (100) co-operable with a guidance system of a robot is provided. In some aspects, a splint body (200) is fixedly coupled to a first object (102) disposed within a pliable housing (104) defining an opening. The splint body includes a laterally-extending medial portion (202) having opposed lateral sides (204, 206), and first and second stabilizing portions (208, 210) extending therefrom and extending about and affixed to the first object. In some aspects, the splint body includes a retractor (300) having a first portion (302) coupled to the splint body, and a second portion (304) extending away from the splint body and engaging the pliable housing about the opening to retract and maintain the pliable housing away from the first object, such that the first object is accessible through the opening, and/or a spacer (400) engaged with the splint body and cooperating with the splint body to separate a second object (106) from the first object within the pliable housing.

Abstract: A tracking and guidance arrangement for a surgical robot system and related method are provided. The arrangement includes a patient-interacting device including an instrument engaged a distal end of a guide arm and a fiducial marker coupled to maxillofacial anatomy of the patient. A detector is connected to an articulating arm and co-operable therewith to be positioned adjacent to the fiducial marker, with the detector being configured to interact with the fiducial marker. A controller device is configured to receive data from the detector relative to the interaction thereof with the fiducial marker, to determine a spatial relation between the fiducial marker and the detector based on the data, to determine a spatial relation of the instrument relative to the fiducial marker, and to direct the instrument to interact with the maxillofacial anatomy of the patient according to the determined spatial relations.

Abstract: Dental implantation systems and methods are provided, including a system comprising a patient-interacting device having an instrument for preparing a site within a patient's mouth for a dental implant. A guiding device in communication with a fiducial marker engaged with the patient's mouth receives the patient-interacting device, and guides the instrument, relative to the fiducial marker, in conjunction with user manipulation of the patient-interacting device. A controller device including a processor is in communication with the guiding device, and directs the patient-interacting device via the guiding device to prepare the site to receive the dental implant. An engagement sensor is operably engaged with the patient-interacting device and communicates with the controller device. The controller device is responsive to sensed disengagement between the patient-interacting device and the user to direct the guiding device to maintain the patient-interacting device at a minimum vertical disposition.

Abstract: A hook plate for use in conjunction with a fracture fixation plate, said fracture fixation plate including a bone contacting surface and an opposite surface, said hook plate comprising a substantially rigid plate having a first portion and a second portion; the first portion adapted for slidable engagement with, said opposite surface of said fracture fixation plate; the second portion configured to wrap around an edge of said fracture fixation plate to engage with a bone fragment and reduce a fracture; the first portion being substantially flat and defining a first portion plane; the second portion having at least two projections which curve downward to a position below the first portion plane and terminate in hook ends adapted to engage with said bone fragment; the first portion including a slot that transects said hook plate from a surface of said hook plate that faces the fracture fixation plate to an opposing surface of said hook plate for engagement with a fastener on said opposite surface of said fractu

Abstract: Dental implantation systems and methods are provided, including a site preparation device for preparing a site within a patient's mouth for receiving an anchor portion of a dental implant. An implant preparation device forms a crown portion of the dental implant for reception by the anchor portion. A guidance device communicates with a fiducial marker engaged with the patient's mouth, to interchangeably receive the site and implant preparation devices, and to guide the site and/or implant preparation device, relative to the fiducial marker, in conjunction with manipulation thereof by a user. A planning device communicates with and via the guidance device, and determines an arrangement of the dental implant at the site, to direct the site preparation device to prepare the site to receive the dental implant arrangement, and to direct the implant preparation device to prepare the crown portion for receipt by the anchor portion.

Abstract: A method of implementing a splint device, and associated splint device are provided for a guidance system of a surgical robot. An adhesive material is engaged with a first stabilizing portion of a first splint portion, and the adhesive material is engaged with a second stabilizing portion of a second splint portion. The first or second splint portion has a mounting portion extending outwardly therefrom, The first and second splint portions are removably engaged with each other and about a tooth of a patient such that, when engaged, the first stabilizing portion is generally opposed to and laterally spaced apart from the second stabilizing portion to define a channel therebetween, with the mounting portion being disposed and extending outwardly of the channel, and with the first and second stabilizing portions defining the channel being secured to respective sides of the tooth via the adhesive material.

Abstract: A plate for fracture fixation, a system and methods are provided including a plurality of individually adjustable heads and various features and accessories to achieve: a.) superior fixation of the plate to osteoporotic diaphyseal bone; b.) improved visualization of the fracture line; c.) intraoperative adjustability to achieve better contact of the plate and the bone; d.) reduced risk of post-surgery tendon rupture; d.) improved fixation of small volar marginal fragments; e.) improved targeting and fixing of particular fractured bone fragments and, f.) reduced surgical operation time.

Abstract: A grooved slot is provided in a bone fixation device for osteosynthesis that permits adjustment of the bone fixation device relative to the bone, before the bone fixation device is finally fixed to the bone. The grooves are formed on the two longitudinally extending, facing walls of the slot, with the grooves on a first side wall of the slot having a vertical displacement of exactly one-half pitch relative to the grooves on the second, opposite side wall of the slot.

Abstract: A grooved slot is provided in a bone fixation device for osteosynthesis that permits adjustment of the bone fixation device relative to the bone, before the bone fixation device is finally fixed to the bone. The grooves are formed on the two longitudinally extending, facing walls of the slot, with the grooves on a first side wall of the slot having a vertical displacement of exactly one-half pitch relative to the grooves on the second, opposite side wall of the slot.

Abstract: A method for joint replacement is provided. A representation of a first bone is created, and a representation of a second bone is created. Bone preparation for implanting a first implant on the first bone is planned. The first bone to receive the first implant is prepared by manipulating a surgical tool to sculpt the first bone. Bone preparation for implanting a second implant on the second bone after preparing the first bone is planned. The second bone to receive the second implant is prepared by manipulating the surgical tool to sculpt the second bone.

Abstract: A tracking and guidance arrangement for a surgical robot system and related method are provided. The arrangement includes a patient-interacting device including an instrument engaged a distal end of a guide arm and a fiducial marker coupled to maxillofacial anatomy of the patient. A detector is connected to an articulating arm and co-operable therewith to be positioned adjacent to the fiducial marker, with the detector being configured to interact with the fiducial marker. A controller device is configured to receive data from the detector relative to the interaction thereof with the fiducial marker, to determine a spatial relation between the fiducial marker and the detector based on the data, to determine a spatial relation of the instrument relative to the fiducial marker, and to direct the instrument to interact with the maxillofacial anatomy of the patient according to the determined spatial relations.

Abstract: A grooved slot is provided in a bone fixation device for osteosynthesis that permits adjustment of the bone fixation device relative to the bone, before the bone fixation device is finally fixed to the bone.

Abstract: A bone screw and a method for using same, the bone screw comprising an elongated shaft including a proximal end, a distal end, a leading portion, and intermediate portion and a trailing portion, the elongated shaft defining a longitudinal axis; a cannula bored completely through said elongated shaft extending from said distal end to said proximal end, the cannula aligned with said longitudinal axis; the leading portion having at least one thread; the intermediate portion being unthreaded; and the trailing portion comprising a threaded tapered head adapted engage a threaded hole at a selectable angle.

Abstract: A device is provided including a distal nail portion and a proximal nail portion that can be connected to each other to attain a rigid configuration. The device is to be placed internally within the medullary cavities of bones. The device is placed intramedullarily in order to minimize incision size, excessive bone resection and post-operative tendon damage and tenderness. Additionally, one particular method for using the device is provided that includes placing and affixing the distal nail in bone, placing the proximal nail in bone, connecting the distal nail to the proximal nail, doing the desired geometrical adjustments, affixing the proximal nail to the distal nail by tightening the connection and affixing the proximal nail to attain a rigid configuration.

Abstract: Dental implantation systems and methods are provided, including a system comprising a patient-interacting device having an instrument for preparing a site within a patient's mouth for a dental implant. A guiding device in communication with a fiducial marker engaged with the patient's mouth receives the patient-interacting device, and guides the instrument, relative to the fiducial marker, in conjunction with user manipulation of the patient-interacting device. A controller device including a processor is in communication with the guiding device, and directs the patient-interacting device via the guiding device to prepare the site to receive the dental implant. An engagement sensor is operably engaged with the patient-interacting device and communicates with the controller device. The controller device is responsive to sensed disengagement between the patient-interacting device and the user to direct the guiding device to maintain the patient-interacting device at a minimum vertical disposition.