Patents by Inventor Juan Sanchez-Ramos

Juan Sanchez-Ramos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating chemical dependency in mammals and a composition therefor
    Publication number: 20030153552
    Abstract: An essentially pure noribogaine compound having the formula: 1
    Type: Application
    Filed: February 14, 2002
    Publication date: August 14, 2003
    Inventors: Deborah C. Mash, Juan Sanchez-Ramos, William Lee Hearn
  • Bone marrow cells as a source of neurons for brain and spinal cord repair
    Patent number: 6528245
    Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: March 4, 2003
    Assignee: University of South Florida
    Inventors: Juan Sanchez-Ramos, Shijie Song, William Janssen, Paul Sanberg, Thomas Freeman
  • BONE MARROW CELLS AS A SOURCE OF NEURONS FOR BRAIN AND SPINAL CORD REPAIR
    Publication number: 20020146821
    Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.
    Type: Application
    Filed: May 7, 1999
    Publication date: October 10, 2002
    Inventors: JUAN SANCHEZ-RAMOS, SHIJIE SONG, WILLIAM JANSSEN, PAUL SANBERG, THOMAS FREEMAN
  • Method of treating chemical dependency in mammals and a composition therefor
    Patent number: 6348456
    Abstract: An essentially pure noribogaine compound having the formula: wherein R is hydrogen or a hydrolyzable group of the formula: wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted by lower alkyl or lower alkoxy groups, wherein the noribogaine compound having the hydrolyzable group hydrolyzes in vivo to form 12-hydroxy ibogamine.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: February 19, 2002
    Inventors: Deborah C. Mash, Juan Sanchez-Ramos, W. Lee Hearn