Patents by Inventor Juan Saus

Juan Saus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating and diagnosing disease using inhibitors of goodpasture antigen binding protein
    Patent number: 10633455
    Abstract: The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: April 28, 2020
    Assignee: University of Valencia
    Inventors: Juan Saus, Fernando Revert, Ramón Merino Pérez, Jesús Merino Pérez, Francisco Revert-Ros
  • GPBP inhibition using Qpeptidomimetics
    Patent number: 10544083
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: January 28, 2020
    Assignee: Universitat de València
    Inventors: Juan Saus, Santos Fustero, Juan F. Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert
  • GPBP inhibition using Q2 peptidomimetics
    Publication number: 20180179139
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 28, 2018
    Inventors: Juan Saus, Santos Fustero, Juan F. Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert
  • Methods for treating and diagnosing disease
    Publication number: 20170218088
    Abstract: The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.
    Type: Application
    Filed: April 12, 2017
    Publication date: August 3, 2017
    Inventors: Juan Saus, Fernando Revert, Ramón Merino Pérez, Jesús Merino Pérez, Francisco Revert-Ros
  • Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes
    Publication number: 20170204197
    Abstract: Disclosed herein are methods for treating type 2 diabetes, limiting development of type 2 diabetes, and treating a pre-diabetic state by administering to a subject in need thereof a GPBP inhibitor. Also disclosed herein are methods for diagnosing a pre-diabetic state and for diagnosing a propensity to develop type 2 diabetes by determining an amount of GPBP in a sample from a subject and comparing to control.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 20, 2017
    Inventors: Juan SAUS, Fernando REVERT, Francisco REVERT-ROS
  • Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition
    Publication number: 20160184274
    Abstract: Methods of using inhibitors of Goodpasture Antigen Binding Protein for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition (EMT), treating an invasive tumor, and detecting EMT in a tissue are described.
    Type: Application
    Filed: December 30, 2015
    Publication date: June 30, 2016
    Inventors: Juan Saus, Fernando Revert, Aida Artigot, Francisco Revert-Ros, Ernesto Lopez-Pascual, Raul Blasco, Nuria Roda, Juan F. Sanz-Cervera, Roberto Gozalbo-Rovira
  • GPBP inhibition using Q2 peptidomimetics
    Publication number: 20160083327
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 24, 2016
    Inventors: Juan Saus, Santos Fustero, Juan F. Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert
  • GPBP inhibition using Q2 peptidomimetics
    Patent number: 9199936
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: December 1, 2015
    Assignee: Fibrostatin Sociedad Limitada
    Inventors: Juan Saus, Santos Fustero, Juan F Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert
  • GPBP-1 inhibition and its therapeutic use
    Publication number: 20150320730
    Abstract: The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.
    Type: Application
    Filed: June 17, 2015
    Publication date: November 12, 2015
    Inventors: Juan Saus, Francisco Ravert-Ros, Fernando Revert, Carmen Aguado-Velasco, Ernesto Lopez-Pascual, Alejandra Maria Perez-Sastre, Raúl Blasco, Héctor Pérez-Montoyo
  • GPBP-1 inhibition and its therapeutic use
    Patent number: 9066938
    Abstract: The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: June 30, 2015
    Assignees: Fibrostein, S.L., Universitat de Valencia
    Inventors: Juan Saus, Francisco Revert-Ros, Fernando Revert, Carmen Aguado-Velasco, Ernesto López-Pascual, Alejandra María Pérez-Sastre, Raúl Blasco, Héctor Pérez-Montoyo
  • Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes
    Publication number: 20150093378
    Abstract: Disclosed herein are methods for treating type 2 diabetes, limiting development of type 2 diabetes, and treating a pre-diabetic state by administering to a subject in need thereof a GPBP inhibitor. Also disclosed herein are methods for diagnosing a pre-diabetic state and for diagnosing a propensity to develop type 2 diabetes by determining an amount of GPBP in a sample from a subject and comparing to control.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Inventors: Juan SAUS, Fernando REVERT, Francisco REVERT-ROS
  • Goodpasture Antigen Binding Protein and Its Detection
    Publication number: 20150064716
    Abstract: The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 5, 2015
    Inventors: Juan Saus, Fernando Revert
  • GPBP inhibition using Q2 peptidomimetics
    Publication number: 20140080852
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Application
    Filed: October 25, 2013
    Publication date: March 20, 2014
    Applicant: FIBROSTATIN, S.L.
    Inventors: Juan Saus, Santos Fustero, Juan F Sanz-Cervera, Enrique Pérez-Payá, Raül Blasco, Francisco Revert-Ros, Fernando Revert
  • GPBP-1 inhibition and its therapeutic use
    Publication number: 20140005134
    Abstract: The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.
    Type: Application
    Filed: July 2, 2013
    Publication date: January 2, 2014
    Inventors: Juan Saus, Francisco Revert-Ros, Fernando Revert, Carmen Aguado-Velasco, Ernesto López-Pascual, Alejandra Maria Pérez-Sastre, Raúl Blasco, Héctor Pérez-Montoyo
  • GPBP inhibition using Qpeptidomimetics
    Patent number: 8586776
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: November 19, 2013
    Assignee: FibroStatin, S.L.
    Inventors: Juan Saus, Santos Fustero, Juan F. Sanz-Cervera, Enrique Perez-Paya, Raul Blasco, Francisco Revert-Ros, Fernando Revert
  • Methods for treating and diagnosing disease
    Publication number: 20120213800
    Abstract: The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.
    Type: Application
    Filed: February 21, 2012
    Publication date: August 23, 2012
    Applicant: Fibrostatin S.L.
    Inventors: Juan Saus, Fernando Revert, Ramón Merino, Jesús Merino, Francisco Revert-Ros
  • Goodpasture Antigen Binding Protein and its Detection
    Publication number: 20110189707
    Abstract: The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.
    Type: Application
    Filed: April 11, 2011
    Publication date: August 4, 2011
    Inventors: Juan Saus, Fernando Revert
  • GPBP inhibition using Q2 peptidomimetics
    Publication number: 20110105545
    Abstract: Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis.
    Type: Application
    Filed: November 5, 2010
    Publication date: May 5, 2011
    Applicant: FIBROSTATIN, S.L.
    Inventors: JUAN SAUS, SANTOS FUSTERO, JUAN F. SANZ-CERVERA, ENRIQUE PEREZ-PAYA, RAUL BLASCO, FRANCISCO REVERT-ROS, FERNANDO REVERT
  • Goodpasture antigen binding protein and its detection
    Patent number: 7935492
    Abstract: The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: May 3, 2011
    Assignee: Fibrostatin, Sociedad Limitada
    Inventors: Juan Saus, Fernando Revert
  • Goodpasture Antigen Binding Protein
    Publication number: 20100247553
    Abstract: The present invention provides isolated nucleic acid sequences and expression vectors encoding the Goodpasture antigen binding protein (GPBP), substantially purified GPBP, antibodies against GPBP, and methods for detecting GPBP.
    Type: Application
    Filed: October 15, 2009
    Publication date: September 30, 2010
    Inventor: Juan Saus