Abstract: An antibody-drug conjugate containing a side chain of a functional small molecule for enhancement of targeted treatment of cancers and refractory diseases is provided. The preparation of such conjugate, pharmaceutical compositions, and methods in treatment of refractory diseases are also provided.

Abstract: A method, a device and a medium for information processing, the method includes: receiving second page address information input into a first page, the second page address information being associated with multimedia content information; acquiring multimedia content information associated with a second page based on the second page address information; and displaying a multimedia display window in the first page and displaying the multimedia content information associated with the second page in the multimedia display window.

Abstract: The present disclosure generally relates to conjugates, compounds, and compositions comprising a MUC16 antibody, and to methods of using the conjugates for treating cancers and tumors.

Abstract: The present disclosure generally relates to conjugates, compounds, and compositions comprising a PTK7 antibody, and to methods of using the conjugates for treating cancers and tumors.

Abstract: Provided is a photovoltaic module, including a first intermediate busbar having a first lead-out terminal provided at an end thereof; a second intermediate busbar having a second lead-out terminal provided at an end thereof; and a first jumper wire arranged on a first isolation bar; the first lead-out terminal and the second lead-out terminal are located on two opposite sides of the first jumper wire, and the first lead-out terminal and the second lead-out terminal abut against two opposite side surfaces of the first isolation bar or overlap a top surface of the first isolation bar. Compared with the related art, the first isolation bar where the first jumper wire is located is clamped or pressed by the first lead-out terminal and the second lead-out terminal, to prevent short circuit or shielding of the cell caused by free movement of the first jumper wire, the first and second intermediate busbars.

Abstract: The present disclosure presents a device and method for monitoring and early warning of information perception regarding urban yellow mud water, featuring a rainfall collecting component, a video shooting component, a sediment content monitoring component, a water level monitoring component and a main controller. The video shooting component evaluates the long-term trend of yellow mud water production in a monitoring area by analyzing the color depth of captured water flow, sediment content in the pipeline's flow section, and meteorological rainfall data from the rainfall collecting component. Utilizing data on color, sediment content, flow section, and rainfall, this system achieves unsupervised real-time monitoring and precise early warning for yellow mud water. It provides a scientific basic for traceability, dynamic monitoring, and address challenges such as low measurement accuracy and omitted applicability found in existing methods.

Abstract: A heteroaryloxynaphthalene compound, in particular, compound A or a pharmaceutically acceptable salt thereof is used in preparing a medicament for treating a tumor-related disease. Compound A or the pharmaceutically acceptable salt thereof exhibits good efficacy against tumors and good tolerance, and thus has clinical potential for treating tumors.

Abstract: Some embodiments of the disclosure provide a quality control method for data annotation on a fundus image. In some examples, the method includes: acquiring a plurality of fundus images; performing standardization processing on the fundus images to obtain a plurality of standardized fundus images; performing preliminary filtering on quality of the standardized fundus images to acquire a plurality of qualified fundus images; preparing a target fundus image set; a plurality of first annotation doctors respectively annotating the images of the target fundus image set, to acquire a plurality of groups of doctor annotation results; calculating, on the basis of the doctor annotation results, self-consistency and gold-standard consistency of the corresponding first annotation doctors, to acquire the doctor annotation results of the first annotation doctors satisfying a preset condition as target annotation results; and gathering a plurality of groups of target annotation results to acquire a final annotation result.

Abstract: The disclosure is directed to an antibody and an antibody-drug conjugate (ADC) including a monoclonal antibody, or an antigen-binding fragment thereof, conjugated to a cytotoxin, directed against B-cell maturation antigen (BCMA). The BCMA antibody and its ADCs are useful for treatment of multiple myeloma cells, B-cell mediated or plasma cell mediated disease, and immune disorders as well as for detecting BCMA. Further disclosed are pharmaceutical compositions and medical treatment methods.

Abstract: A pressure-regulating inertial friction welding system and a method are provided. The pressure-regulating inertial friction welding system includes: an inertial friction welding machine including a flywheel set and a tailstock arranged oppositely, the flywheel set and the tailstock being provided with clamping assemblies, the flywheel set being connected to a rotation driving element, and the tailstock being connected to a servo feed assembly; and a control assembly including a controller, a strain gauge and a temperature monitor, the strain gauge being capable of measuring and obtaining strain data of the workpiece to be welded and sending the strain data to the controller, and the temperature monitor being capable of sending a temperature of the welding zone to the controller; and the controller being configured to control the servo feed assembly to regulate a pressure between the workpieces to be welded.

Abstract: Provided herein is a process for preparing a homogeneous conjugate of an antibody or antibody-like protein via linkage of cysteine sites between heavy-light chains in the IgG antibody or antibody-like protein. It also relates to method of making the conjugates in a specific manner including either generation of specific thiols of an antibody or antibody-like protein agent, followed by reaction with drug/linker complexes, or generation of specific thiols of an antibody or antibody-like protein agent and conjugation of a synthetic linker-drug assembly with the thiols simultaneously in one pot reaction, to provide conjugates with over 75%, in most cases more than 80% of payloads linked at the specific cysteine sites between heavy-light chains of the IgG antibody or antibody-like protein. It also relates to methods of using the homogeneous conjugate in targeted prophylaxis or treatment of cancer, infection and immunological disorders.

Abstract: Provided is a photovoltaic module, including a first intermediate busbar having a first lead-out terminal provided at an end thereof; a second intermediate busbar having a second lead-out terminal provided at an end thereof; and a first jumper wire arranged on a first isolation bar; the first lead-out terminal and the second lead-out terminal are located on two opposite sides of the first jumper wire, and the first lead-out terminal and the second lead-out terminal abut against two opposite side surfaces of the first isolation bar or overlap a top surface of the first isolation bar. Compared with the related art, the first isolation bar where the first jumper wire is located is clamped or pressed by the first lead-out terminal and the second lead-out terminal, to prevent short circuit or shielding of the cell caused by free movement of the first jumper wire, the first and second intermediate busbars.

Abstract: Some embodiments of the disclosure provide a measuring method and measuring apparatus of a blood vessel diameter of a fundus image. In some examples, the measuring method include the following steps: acquiring a fundus image, generating a blood vessel segmentation image based on the fundus image, performing resolution enhancement on the blood vessel segmentation image, extracting blood vessel skeletons from the enhanced blood vessel segmentation image and performing fitting on the blood vessel skeletons to obtain a continuous blood vessel skeleton and a vessel diameter measurement direction of measurement pixel points, generating a blood vessel contour corresponding to the measurement pixel points based on the enhanced blood vessel segmentation image, and calculating a blood vessel diameter corresponding to the measurement pixel points based on a number of blood vessel pixel points in the blood vessel contour.

Abstract: A recommendation method, an electronic device and a computer-readable medium are provided. The recommendation method, applied to a first client, includes: in response to a first operation, displaying an information configuration page; in response to a trigger operation on a first control in the information configuration page, displaying an object aggregation page, where the object aggregation page includes recommendation description information of at least one candidate object corresponding to a target account; in response to a selection operation on recommendation description information of at least one target object in the at least one candidate object, updating the information configuration page by using the recommendation description information of the at least one target object; and in response to a trigger operation on a second control in the information configuration page, generating an object recommendation interface corresponding to the information configuration page.

Abstract: The present disclosure provides a cell patch cryopreservation solution, which includes: a cryoprotectant, a buffer, a reducing agent, a calcium channel inhibitor and an apoptosis inhibitor. The present disclosure also provides a method of cryopreserving a cell patch by using the aforementioned cell patch cryopreservation solution. The cell patch cryopreservation solution and the method of cryopreserving a cell patch provided by the present disclosure can maintain the structural integrity and the cell activity of the cell patch.

Abstract: A negative electrode sheet, a secondary battery, and an electric device. The negative electrode sheet includes a negative electrode current collector, a buffer layer, and an active layer, where the buffer layer is located between the negative electrode current collector and the active layer; the buffer layer includes a first binder; and an active material of the active layer includes silicon-carbon composite particles, and the silicon-carbon composite particles include a porous carbon material and a silicon material located in pores of the porous carbon material.

Abstract: Provided in the present invention are a splint nucleic acid molecule for cyclizing a single-stranded nucleic acid molecule and an application therefor. The splint nucleic acid molecule is composed of a 5? terminal fragment and a 3? terminal fragment, the 5? terminal fragment being adapted to forming a first complementary region with a 5? terminal of the single-stranded nucleic acid molecule, and the 3? terminal fragment being suited to forming a second complementary region with a 3? terminal of the single-stranded nucleic acid molecule, the length of the first complementary region and the second complementary region being different.