Abstract: Ultrasound systems and methods are provided using mass characterization frequency methods that provide for predicting benign or malignant lesions, a response to treatment, tumor grading, and/or the expressions of immunohistochemical biomarkers, which are currently used for breast cancer classification and hormone therapy determination. The systems and methods are based on the shear wave parameter, mass characteristic frequency. The status of malignancy, treatment response, grade, and/or each immunohistochemical biomarker may be determined based on a corresponding mass characteristic frequency threshold.

Abstract: Ultrasound systems and methods are provided using mass characterization frequency methods that provide for predicting benign or malignant lesions, a response to treatment, tumor grading, and/or the expressions of immunohistochemical biomarkers, which are currently used for breast cancer classification and hormone therapy determination. The systems and methods are based on the shear wave parameter, mass characteristic frequency. The status of malignancy, treatment response, grade, and/or each immunohistochemical biomarker may be determined based on a corresponding mass characteristic frequency threshold.