Patents by Inventor Jubrail Rahil

Jubrail Rahil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acyl phosphonate inhibitors of &bgr;-lactamases
    Patent number: 6599889
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: July 29, 2003
    Assignee: MethylGere, Inc.
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt
  • Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
    Patent number: 6472406
    Abstract: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not require a &bgr;-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: October 29, 2002
    Assignee: MethylGene, Inc.
    Inventors: Jeffrey M. Besterman, Daniel Delorme, Jubrail Rahil
  • Acyl phosphonate inhibitors of beta-lactamases
    Publication number: 20020022607
    Abstract: The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not possess a &bgr;-lactam pharmacophore. These new inhibitors are fully synthetic, allowing ready access to a wide variety of structurally related analogs. Certain embodiments of these new inhibitors also bind bacterial DD-peptidases, thus potentially acting both as &bgr;-lactamase inhibitors and as antibiotics.
    Type: Application
    Filed: March 1, 2001
    Publication date: February 21, 2002
    Inventors: Jeffrey M. Besterman, Jubrail Rahil, Rex Pratt