Abstract: A smart advisor receives blood test data for a sample and applies a series of rules in a pipeline to determine a match between the results from the sample and one of a set of possible presumptive patterns. The presumptive patterns each correspond to a condition. The smart advisor generates an enhanced report that identifies the selected pattern. The report may also include a likelihood that the presumptive pattern is a correct match for the sample as well as comments and notes. The comments and notes may suggest additional testing that should be performed, identify common diagnosis pitfalls, identify demographic factors that may correlate with diagnosis, suggest family studies to confirm inheritance of a variant, and alert on reproductive risks if both partners are carriers of a specific variant.