Patents by Inventor Judith E. Miller

Judith E. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Forward mutation assay based on 5-fluorouracil resistance
    Patent number: 7923204
    Abstract: Disclosed herein is a novel forward mutation assay based on 5-fluorouracil (5-FU) resistance which utilizes a strain of Salmonella typhimurium derived from the Ames strain TA100. More specifically, the invention provides a high throughput alternative to the standard Ames mutation assay for the evaluation of the genotoxicity activity of compounds during an early stage of the drug development process. The invention also identifies the upp locus as a mutational target that is capable of detecting a diverse spectrum of mutagenic events and further describes a S. typhimurium tester strain, designated FU100 (his+, rfa, ?uvrB, pkM101, 5-fluorouridine resistant) for use in the assay of the invention.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: April 12, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Warren E. Glaab, Thomas R. Skopek, Katerina Vlasakova, Judith E. Miller