Patents by Inventor Judith G. Deal

Judith G. Deal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6495699
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: December 17, 2002
    Assignee: Agouron Pharmaceuticals Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Publication number: 20020173515
    Abstract: Novel derivatives of 5-thia- and 5-selenopyrimidinone are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
    Type: Application
    Filed: October 23, 2001
    Publication date: November 21, 2002
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Publication number: 20020019429
    Abstract: The present invention is directed to compound of the formula I: 1
    Type: Application
    Filed: August 6, 2001
    Publication date: February 14, 2002
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K.M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Patent number: 6323210
    Abstract: Novel derivatives of 5-thia- and 5-selenopyrimidinone are sound to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: November 27, 2001
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6306892
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R 5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: October 23, 2001
    Assignees: Agouron Pharmaceuticals, Inc., Syntex Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Publication number: 20010018443
    Abstract: Novel derivatives of 5-thia- and 5-selenopyrimidinone are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
    Type: Application
    Filed: February 14, 2001
    Publication date: August 30, 2001
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Patent number: 6207670
    Abstract: Novel derivatives of 5-thia- and 5-selenopyrimidinone are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: March 27, 2001
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
    Patent number: 6174915
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R5, X, Y, and  are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: January 16, 2001
    Assignees: Agouron Pharmaceuticals, Inc., Syntex (U.S.A.) Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6008243
    Abstract: The present invention is directed to compound of the formula I: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y, and ##STR2## are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: December 28, 1999
    Assignees: Agouron Pharmaceuticals, Inc., Syntex (U.S.A.), Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Jian Jeffrey Chen, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Patent number: 5945427
    Abstract: The present invention is directed to derivatives of 5-thia- and 5-selenopyrimidinone are useful as inhibitors of the enzyme glycimide ribonucleotide formyl transferase (GARFT) and amino imidozole carboxamide ribonucleotide formyl transferase (AICARFT), pharmaceutical compositions containing these derivatives, and methods of using these derivatives. The present invention is also directed to intermediates useful for preparing these derivatives and methods of preparing these intermediates.
    Type: Grant
    Filed: January 6, 1998
    Date of Patent: August 31, 1999
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
    Patent number: 5739141
    Abstract: The present invention is directed to derivatives of 5-thia- and 5-selenopyrimidinone, which are useful as inhibitors of the enzymes glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase AICARFT), pharmaceutical compositions containing these derivatives, and methods of using these derivatives. The present invention is also directed to intermediates useful for preparing these derivatives and methods of preparing these intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 14, 1998
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal
  • Methods for preparing antiproliferative 5-substituted pyrimidone compounds
    Patent number: 5726312
    Abstract: Intermediates for preparing derivatives of 5-thia- and 5-selenopyrimidinone, ##STR1## which are useful as inhibitors of the enzymes glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). The present invention is also directed to methods of preparing these intermediates.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: March 10, 1998
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael D. Varney, William H. Romines, Cynthia L. Palmer, Judith G. Deal