Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of promoting protective immunity and/or for preventing and/or treating bacterial or viral infections and/or for limiting immune mediated pathology following infection in an individual comprising delivering to the individual in need an effective unit dose form of reduced nicotinamide.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of cardiovascular disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention maintain or improve cardiovascular tissue and cellular function. In another embodiment of the invention, said compounds and compositions of the invention enhance cardiovascular recovery after injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of neurological disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention maintain or improve brain function, in particular brain energy deficits. In another embodiment of the invention, compounds and compositions of the invention improve neurological recovery and regeneration after injury or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat neurological diseases and/or conditions and/or recovery after injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of lung disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve the lung by maintaining or improving lung function. In another embodiment of the invention, the compounds and compositions of the invention improve lung recovery and regeneration after injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of liver disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve liver by maintaining or improving liver function; maintaining or improving hepatocyte function; and improving liver recovery and regeneration after injury, transplantation or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat liver diseases and/or conditions such as: non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease, hepatic steatosis, cirrhosis and/or recovery and regeneration after liver injury, transplantation or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of kidney diseases and conditions. In one embodiment of the invention, said compounds and compositions of the invention improve kidney function by reducing formation of kidney cysts, reducing glomerule dilatation, reducing renal cell apoptosis and preventing increases in blood urea nitrogen. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat acute kidney injury (AKI), chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, nephrotic syndrome, renal fibrosis and kidney cancer.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of skeletal muscle disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve skeletal muscle by maintaining or improving muscle function; maintaining or increasing muscle mass; maintaining or improving muscle strength; and improving muscle recovery and regeneration after injury or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat skeletal muscle diseases and/or conditions such as: cachexia or precachexia; sarcopenia, myopathy, dystrophy, and/or recovery after intense exercise, muscle injury or surgery.