Patents by Inventor Judith M. Healy

Judith M. Healy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein
    Patent number: 6706495
    Abstract: The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal GTP-binding protein. The present invention further relates to a method of producing Staphylococcal GTP-binding protein and a method for high throughput screening to identify potential antimicrobial compounds useful against Staphylococcal bacterial strains.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: March 16, 2004
    Assignee: Anadys Pharmaceuticals
    Inventors: Yueh-tyng Chien, Jason A. Thresher, C. Richard Wobbe, Judith M. Healy
  • Staphylococcus strains comprising an inducible gene encoding an RNA polymerase specificity factor
    Patent number: 6451582
    Abstract: The present invention relates to a recombinant organism, and a bacterial strain such as Staphylococcus, and S. aureus, in particular. The organism has a regulatable gene for encoding an RNA polymerase specificity factor required for expression of at least one gene essential for growth of the organism. The regulatable gene is one which is responsive to an exogenous effector molecule, and may in particular be an inducer-responsive gene including an operator site, such as a lac operator, to which a repressor, such as a lacl-encoded repressor, is capable of binding. The regulatable gene may in particular be an IPTG responsive plaC allele.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: September 17, 2002
    Assignee: Anadys Pharmaceuticals, Inc
    Inventors: Judith M. Healy, C. Richard Wobbe, Patricia Carroll, Jason Thresher
  • Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein
    Publication number: 20020055138
    Abstract: The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal GTP-binding protein. The present invention further relates to a method of producing Staphylococcal GTP-binding protein and a method for high throughput screening to identify potential antimicrobial compounds useful against Staphylococcal bacterial strains.
    Type: Application
    Filed: February 23, 2001
    Publication date: May 9, 2002
    Inventors: Yueh-Tyng Chien, Jason A. Thresher, C. Richard Wobbe, Judith M. Healy
  • Regulated gene expression in yeast
    Patent number: 6365409
    Abstract: The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: April 2, 2002
    Assignee: Anadys Pharmaceuticals, Inc
    Inventors: John D. Bradley, Craig M. Thompson, Jeffrey B. Moore, C. Richard Wobbe, Judith M. Healy, Caroline E. Donnelly
  • M. tuberculosis RNA polymerase alpha subunit
    Patent number: 6355464
    Abstract: The present invention provides isolated nucleic acids encoding RNA polymerase alpha subunit from M. tuberculosis, vectors comprising the nucleic acids, cells comprising the vectors, and methods for producing M. tuberculosis alpha subunit. The invention also provides in vitro and in vivo methods for high-throughput screening to identify inhibitors of M. tuberculosis RNA polymerase.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: March 12, 2002
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Judith M. Healy, Jana Bodorova, Kelvin T. Lam, Andrea J. Lesoon
  • Regulated gene expression in yeast
    Patent number: 6004779
    Abstract: The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: December 21, 1999
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: John D. Bradley, Craig M. Thompson, Jeffrey B. Moore, C. Richard Wobbe, Judith M. Healy, Caroline E. Donnelly