Patents by Inventor Judith Margarete Gottwein

Judith Margarete Gottwein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PURIFYING WHOLE VIRUS PARTICLES
    Publication number: 20230272350
    Abstract: The present invention relates to a method of purifying whole HCV particles, the method comprising the steps of a) providing a cell culture supernatant comprising virus particles, b) purification and/or concentration of the cell culture supernatant, c) purification and/or concentration of the product of above step b) using steric exclusion chromatography (SXC) at alkaline pH in the range of 8-10, d) purification and/or concentration of the product of above step c) using sulphated cellulose membrane absorbers (SCMA), e) obtaining purified whole virus particles.
    Type: Application
    Filed: July 12, 2021
    Publication date: August 31, 2023
    Inventors: Judith Margarete Gottwein, Jens Bukh, Anna Offersgaard, Anne Finne Pihl, Michael Wolff, Keven Lothert
  • EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 6A
    Publication number: 20230250402
    Abstract: The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) of genotype 6a that are useful in the fundamental research of HCV as well as in the search of antivirals and vaccines against HCV. In particular, the present invention relates to nucleic acid sequences that comprises HCVs, which are capable of expressing said virus when transfected into cells and are capable of replication or infectivity in cultured cells.
    Type: Application
    Filed: February 8, 2019
    Publication date: August 10, 2023
    Inventors: Jens Bukh, Long Van Pham, Santseharay Ramirez Almelda, Judith Margarete Gottwein, Yi-Ping Li, Jannie Pedersen
  • Development of methods for production of a whole virus vaccine candidate stock and novel adaptive mutations in hepatitis C virus
    Patent number: 10258687
    Abstract: The present invention relates to methods for obtaining a whole virus vaccine candidate stock. The present invention also relates to an inactivated whole virus vaccine candidate stock that can be used for vaccination purposes as well as development of novel high titer virus, which is the preferred virus for this technique.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: April 16, 2019
    Assignee: HVIDOVRE HOSPITAL
    Inventors: Christian Kjærulff Mathiesen, Tanja Bertelsen Jensen, Jens Bukh, Judith Margarete Gottwein
  • DEVELOPMENT OF METHODS FOR PRODUCTION OF A WHOLE VIRUS VACCINE CANDIDATE STOCK AND NOVEL ADAPTIVE MUTATIONS IN HEPATITIS C VIRUS
    Publication number: 20170274067
    Abstract: The present invention relates to methods for obtaining a whole virus vaccine candidate stock. The present invention also relates to an inactivated whole virus vaccine candidate stock that can be used for vaccination purposes as well as development of novel high titer virus, which is the preferred virus for this technique.
    Type: Application
    Filed: April 16, 2015
    Publication date: September 28, 2017
    Inventors: Christian Kjærulff Mathiesen, Tanja Bertelsen Jensen, Jens Bukh, Judith Margarete Gottwein