Patents by Inventor Judith Sebolt-Leopold

Judith Sebolt-Leopold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF
    Publication number: 20200078360
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a quinazoline structure which function as dual inhibitors EGFR and PI3K, and their use as therapeutics for the treatment of cancer (e.g., cancers associated with mutated KRAS and BRAF) (e.g., in combination with MAPK pathway inhibitors (e.g., BRAF inhibitors, MEK inhibitors, ERK inhibitors).
    Type: Application
    Filed: November 3, 2017
    Publication date: March 12, 2020
    Inventors: Christopher Emil WHITEHEAD, Elizabeth ZIEMKE, Judith SEBOLT-LEOPOLD
  • Combination chemotherapy
    Publication number: 20040171632
    Abstract: Mitotic inhibitors such as paclitaxel have improved antitumor activity when used in combination with a selective MEK inhibitor, especially a phenyl amine compound of Formula I and II: 1
    Type: Application
    Filed: November 3, 2003
    Publication date: September 2, 2004
    Inventors: Richard Carleton Gowan, Judith Sebolt-Leopold
  • Method for treating Alzheimer's disease
    Publication number: 20010051642
    Abstract: The present invention provides methods and compositions for inhibiting A&bgr; synthesis and for treating Alzheimer's disease by administering a farnesyl transferase inhibitor of the formula: 1
    Type: Application
    Filed: January 29, 2001
    Publication date: December 13, 2001
    Inventors: Kyunghye Ahn, Mark Richard Emmerling, Taraneh Haske, Donald J. Hupe, Judith Sebolt-Leopold, Harry LeVine, Jeffrey David Scholten
  • Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
    Patent number: 6300501
    Abstract: Inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: October 9, 2001
    Assignee: Warner-Lambert Company
    Inventors: Ellen M. Dobrusin, Annette M. Doherty, James S. Kaltenbronn, Daniele M. Leonard, Dennis J. McNamara, Judith Sebolt-Leopold, Kevon R. Shuler
  • Tricyclic inhibitors of protein farnesyltransferase
    Patent number: 5919780
    Abstract: Compounds of formula I ##STR1## wherein X is N or C--R.sup.9, Y is N--R.sup.10, CH.sub.2, O, S, SO, SO.sub.2, C.dbd.O or CH--OH,R is H or alkyl,R.sup.1 is heteroaryl,n is 1-5, andR.sup.2 -R.sup.10 are H or various substituents,are useful as inhibitors of protein farnesyl transferase and for the treatment of proliferative diseases including cancer, restenosis and psoriasis, and as antiviral agents.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: July 6, 1999
    Assignee: Warner Lambert Company
    Inventors: Gary L. Bolton, Annette M Doherty, James S. Kaltenbronn, John Quin, III, Jeffrey D. Scholten, Judith Sebolt-Leopold, Harold Zinnes
  • Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
    Patent number: 5763577
    Abstract: Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Warner-Lambert Company
    Inventors: Gary Louis Bolton, Alfred Campbell, Richard Gowan, John Cooke Hodges, Donald Hupe, Daniele Leonard, Tomi Sawyer, Judith Sebolt-Leopold, Francis J. Tinney