Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Abstract: The present disclosure relates to sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises N-oxide of active pharmaceutical agent at a level less than 1 wt %, based on weight of the composition. In some case, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

Abstract: Among other things, the present disclosure relates to re-purposing used lithium-ion batteries. The present disclosure includes treating an electrode using a solvent prior to electrochemically relithiating the electrode. In some embodiments, the relithiation may be done using a roll-to-roll device, wherein the electrode may be secured on a first pin and a second pin, then it may be unwound and submerged in an electrolyte solution. Lithium ions may be inserted into the electrode using a voltage. The layer of lithium may provide lithium ions to the electrode.

Abstract: The present disclosure provides a magnetic multi-turn sensor comprising a continuous coil of magnetoresistive elements and a method of manufacturing said sensor. The continuous coil is formed on a substrate such as a silicon wafer that has been fabricated so as to form a trench and bridge arrangement that enables the inner and outer spiral to be connected without interfering with the magnetoresistive elements of the spiral winding in between. Once the substrate has been fabricated with the trench and bridge arrangement, a film of the magnetoresistive material can be deposited to form a continuous coil on the surface of the substrate, wherein a portion of the coil is formed in the trench and a portion of the coil is formed on the bridge.

Abstract: Methods, systems, and devices for cache management in a memory subsystem are described. An interface controller may include a first buffer and a second buffer. The interface controller may use the first and second buffers to facilitate operating a volatile memory as a cache for a non-volatile memory. During an access operation, the interface controller may use the buffer to transfer data between the volatile memory, non-volatile memory, and another device. In response to the access operation, the interface controller may use the second buffer to transfer second data from the volatile memory to the non-volatile memory.

Abstract: A knob locking assembly for a laparoscopic medical device is provided. The knob locking assembly includes a lock configured to engage the knob locking assembly with a drive tube housing of the laparoscopic medical device in extended and retracted positions where the knob locking assembly rotates but does not translate with respect to the drive tube housing when engaged. The knob locking assembly also has a biasing member that provides a biasing force for biasing the lock in each of the extended and retracted positions to lock out longitudinal translation of the rotatable drive assembly when the knob locking assembly is engaged with the drive tube. In addition, the knob locking assembly includes an actuator to counter the biasing force for disengaging the lock to permit longitudinal translation of the rotatable drive assembly via the knob locking assembly when disengaged.

Abstract: An example method is described. The method includes receiving, by a computing system, data indicative of a call into an interactive voice response (IVR) system from a user device and determining, by the computing system and based on the data, a set of actions performed by the user device within the IVR system and a corresponding set of results performed by the IVR system during the call. Additionally, the method includes converting, by the computing system, the set of actions and the corresponding set of results into a sequence of code pairs using a dictionary established based on training data, determining, by the computing system, an activity pattern during the call based on the sequence of code pairs; and calculating, by the computing system, a probability that the call is fraudulent based on the activity pattern during the call.

Abstract: An apparatus includes a client addition circuit structured to interpret a client description for each one of a plurality of clients comprising users of an online platform. An apparatus includes a tranche assignment circuit structured to determine at least one tranche adjustment value in response to the client description for at least one of the plurality of clients in one of the plurality of tranches. An apparatus may execute at least one operation indicated by the at least one tranche adjustment value. An apparatus includes a platform analysis circuit structured to update a tranche analytics profile in response to the execution of the at least one operation indicated by the at least one tranche adjustment value.

Abstract: An infusion set includes a base (221) and a flexible catheter (242) movable from a first catheter position disposed substantially entirely within the base (221) to a second catheter position in which a free end of the catheter (242) is disposed externally of the base (221). An introducer needle (234) is located within the catheter (242) and is movable between a first introducer needle position disposed substantially entirely within the base (221) and a second introducer needle position in which a free end of the introducer needle (234) is disposed externally of the base (221). A spring (281) is activated to move the catheter (242) from the first to the second catheter position and the introducer needle (234) from the first to the second introducer needle position to facilitate insertion of the catheter (242).

Abstract: An RF-shielded window apparatus may include a primary panel and a secondary panel. The primary panel may include a primary RF shield layer disposed between a primary backing substrate and a protective layer. The secondary panel may include a secondary backing substrate and a secondary RF shield layer. The first panel element and the second panel element may be secured to one another such that the primary RF shield layer, the secondary RF shield layer and the protective layer are collectively disposed between the primary backing substrate and the secondary backing substrate. The primary RF shield layer and the secondary RF shield layer may be in electrically-conductive communication with one another. A panel joining strip may help secure the first panel to the second panel, and the electrically-conductive communication may be at least in part by way of the panel joining strip. Associated manufacturing methods are also disclosed.

Abstract: A method of forming a circuit board assembly includes receiving a flat no-lead package. The package includes: a housing having a first side and second side; a circuit disposed within the housing; and an exposed thermal belly pad that is thermally coupled to the circuit and passes at least partially through the first side such that it can be exposed to an environment outside of the housing. The method also includes attaching the second side of the flat no-lead package to a first side of a printed circuit board (PCB) such that the exposed thermal belly pad is opposite the first side of the PCB.

Abstract: A method and model for sustainable leadership development, premised on the sustainable-unsustainable leadership theory (SULT) is set forth herein to intervene in the phenomenon of leadership failure and associated crises. Empirical evidence of leadership failure longitudinally, demonstrated a need for a paradigm shift for leadership. Unnecessary war-related deaths and expenditures, scandals, and other harms to people are unsustainable. The method and model supported by leadership's grand theory, is underpinned by a 3-year exploratory sequential mixed methods study. A theory emerged during theoretical sampling and constant comparative analysis of interviews from six continents, giving rise to the aphorism “leadership in the absence of moral action is unsustainable.” Random sampling from 2,523 global cases, analyzing 2,191 in a quantitative phase, showed statistically significant association between unethical leadership action (ULA) and unsustainable leadership outcomes (ULO), ?2 (1, N=2,191)=119.643, p<0.

Abstract: Memristors are provided, which, in embodiments, comprise a bottom electrode; a top electrode in electrical communication with the bottom electrode, wherein one or both of the bottom and top electrodes is a Schottky electrode; and a dielectric stack between the bottom and top electrodes, the dielectric stack forming a top interface with a bottom surface of the top electrode and a bottom interface with a top surface of the bottom electrode, the dielectric stack comprising a plurality of atomic layer deposition (ALD)-grown atomic sublayers, the plurality comprising an ALD-grown atomic sublayer of a first metal oxide and an ALD-grown atomic sublayer of a second metal oxide. The second metal oxide is different from the first metal oxide and has a greater concentration of oxygen vacancies (VO) than the first metal oxide. The dielectric stack has a thickness of no more than about 5 nm.

Abstract: The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of hepatocellular carcinoma with extrahepatic metastasis. Provided herein are methods and compositions for treatment, screening, diagnosis and prognosis of metastatic cancers. Also provided are monoclonal antibodies and compositions for the treatment of cancers. Provided herein is therapeutic target for the treatment of cancers or as a marker for cancers.

Abstract: A method is used to cut a suture. The method provides a drive wire coupled with a cutter. The cutter has a first blade defining a first plane, and a second blade defining a second plane that is non-parallel with the first plane. The first blade and the second blade define an opening. The method hooks a suture into the opening. The method cuts the suture by pulling the drive wire in a proximal direction.

Abstract: A system for generating a graphical user interface for providing graphical representations of data processed by one or more machine learned networks that allows a user to quickly compare various metrics. In some cases, the graphical user interface may be configured to present metrics related to geographic locations of various entities as well as demographic data of individuals. The metrics may be generated by a machine learned networks, such as a neural network. In some cases, the graphical user interface may be determined based on a type of device, such as a smartphone, laptop, desktop, tablet, or the like.

Abstract: A method of making a plasmonic metal/graphene heterostructure comprises heating an organometallic complex precursor comprising a metal at a first temperature T1 for a first period of time t1 to deposit a layer of the metal on a surface of a heated substrate, the heated substrate in fluid communication with the precursor; and heating, in situ, the precursor at a second temperature T2 for a second period of time t2 to simultaneously form on the layer of the metal, a monolayer of graphene and a plurality of carbon-encapsulated metal nanostructures comprising the metal, thereby providing the plasmonic metal/graphene heterostructure. The heated substrate is characterized by a third temperature T3. The plasmonic metal/graphene heterostructures, devices incorporating the heterostructures, and methods of using the heterostructures are also provided.

Abstract: An infusion set includes a base (221) and a flexible catheter (242) movable from a first catheter position disposed substantially entirely within the base (221) to a second catheter position in which a free end of the catheter (242) is disposed externally of the base (221). An introducer needle (234) is located within the catheter (242) and is movable between a first introducer needle position disposed substantially entirely within the base (221) and a second introducer needle position in which a free end of the introducer needle (234) is disposed externally of the bases (221). A spring (281) is activated to move the catheter (242) from the first to the second catheter position and the introducer needle (234) from the first to the second introducer needle position to facilitate insertion of the catheter (242).

Abstract: Methods and systems include ways to implement change analysis of an automated production line including at least one robot. Monitoring a plurality of operating parameters associated with the automated production line including the at least one robot is followed by recording at least one change to the plurality of operating parameters. A notification is then provided identifying the at least one change to the plurality of operating parameters. The notification can include mapping the at least one change onto a graphical representation of the automated production line, thereby identifying a portion of the automated production line affected by the at least one change. As a result, at least one of the operating parameters can be adjusted in response to the notification. An action can also be performed in response to the notification. In this manner, the change analysis can optimize operation of the automated production line.