Abstract: Systems (100), methods, and machine-executable data structures for the processing of data for the secure creation, administration, manipulation, processing, and storage of electronic data useful in the processing of electronic payment transactions and other secure data processes. Aspects of such systems (100) include trusted platforms (120) by which networked communication devices (110) and merchant systems (130) may registered as trusted entities 110?, 130. Information associated with particular payment means, such as accounts or payment tokens, can be stored on device(s) secure data sets known as virtual or electronic wallets (112), or in the form of secure payment tokens. Common application programming interfaces executed by devices (110) may facilitate push and pull processes between electronic wallets (112) and other secure data stores (136, 120, 160). Users (190) may thereby initiate and complete electronic transactions directly from within applications on trusted devices (110?).

Abstract: A virtual assistant/chatbot to improve clinical workflow for home renal replacement therapies is disclosed herein. A virtual assistant/chatbot includes a patient-facing user interface configured to enable a patient to engage in a virtual chat session by typing, speaking, or otherwise providing information regarding a patient request or issue related to their renal replacement therapy. The virtual assistant/chatbot also includes a backend server-based system configured to provide logic to respond to a patient's requests. The logic defines a sequence of questions and answers for resolving patient queries. The sequence of assistant/chatbot questions and patient answers may be configured in a node arrangement such that certain patient answers/requests lead to additional questions for additional information from a patient.

Abstract: Aspects of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such aspects can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some aspects can include various configurations of the sheath that comprise an elongated tube having a disclosed composition that can form an outer jacket or a strain relief jacket or can be used as the outer layer of the sheath. Aspects of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel and reduce the push force needed for passage of the medical device, thus offering advantages over prior art introducer sheaths.

Abstract: A protective paper towel device includes a disk having a diameter sized to cover at least a portion of a radial end of a roll of paper towel. The disk includes a central slot configured for receiving a paper towel holding rod. The radial end of the upper part of a roll of paper towels is protected from hand contamination.

Abstract: An extensional mode electrostatic microelectromechanical systems (MEMS) gyroscope is described. The MEMS gyroscope operates in an extensional mode. The MEMS gyroscope comprises a vibrating ring structure that is electrostatically excited in the extensional mode.

Abstract: A computer-implemented method includes: receiving, by an augmented reality device, a medical image of a surgical site, generating, by the augmented reality device, a virtual surgical site model based on the medical image; presenting, by the augmented reality device, the virtual surgical site model; receiving, by the augmented reality device, user calibration input; aligning, by the ugmented reality device, the virtual surgical site model with a real-life surgical site based on the user calibration input; and displaying, by the augmented reality device and after the aligning, a virtual insertion path between an incision point and a target point to aid in inserting a tool as part of performing a surgical procedure.

Abstract: A method is provided for lowering blood pressure in a subject in need thereof by administering an angiotensin II receptor blocker pharmaceutical composition to a subject qualified for over-the-counter access to the angiotensin II receptor blocker pharmaceutical composition. In some embodiments, the angiotensin II receptor blocker pharmaceutical composition includes azilsartan medoxomil, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, or valsartan. In some embodiments, the angiotensin II receptor blocker pharmaceutical composition comprises an active ingredient that is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2?-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof.

Abstract: Provided are compositions and methods for determining baseline serum autoantibodies (autoAbs) for use in patient selection and for treatment with immune checkpoint blockade agents to promote avoidance of development of severe immune related adverse events (IRAEs). The treatments include administering anti-cancer agents that are not predicted to cause toxicity to selected patients, and administering agents to reduce predicted toxicity in selected patients.

Abstract: An interactive group-specific player board game method comprising the steps of drawing a grid and labeling a plurality of blocks in a sequential process from 1 to n, wherein n depends on the size of the grid, rolling a dice by each player sequentially and recording a number on the dice until each box on the grid has a unique number, establishing a set of at least 6 rules by the group-specific players, each rule corresponding to a unique action to be performed by the players, rolling the dice by at least one player, moving the number of blocks on the board game corresponding to the number on the dice, receiving the action to be performed by the player based on the unique number on the grid established by the set of rules, determining the completion of the action by the remaining group-specific players.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: The invention relates to a method of preparing a protein formulation including a therapeutic protein, the method comprising the steps of: providing a solution comprising said protein; concentrating the protein in the solution by a first ultra-filtration step; diafiltering the solution with a diafiltration buffer including at least one first excipient, whereby a retentate is obtained comprising the protein and the first excipient; further concentrating the protein in the retentate by a second ultra-filtration step; and adding at least one final excipient, whereby the protein formulation with a desired protein concentration is obtained. According to the inven tion, the method further comprises, before the second ultra-filtration step, adding a second excipient to the retentate obtained from the diafiltration step. The invention is also directed to antibody formulations produced by the foregoing method.

Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A vehicle system includes a vehicle body defining a vehicle interior and a vehicle exterior, one or more detection devices, a sanitization device, and a controller, the controller including a processor and a non-transitory computer readable and executable instruction set, which when executed, causes the processor to receive data from the one or more detection devices, determine a surface at least one of within the vehicle interior or on the vehicle exterior contacted by a user based at least in part on the data from the one or more detection devices, determine whether the user is within the vehicle based at least in part on the data from the one or more detection devices, and direct the sanitization device to sanitize the surface based at least in part on the data from the one or more detection devices.

Abstract: A computer-implemented method for storing documents in a centralized database system based on geographical data localization includes receiving, by a database manager, a request to update a document according to a data localization criterion, the document stored in a local storage device of the centralized database system. The method further includes determining, by the database manager, a geographical location for a local copy of the document based on an attribute of the document matching the localization criterion. The method further includes creating, by the database manager, a remote copy of the document on a storage device that is physically located in the geographical location. The method further includes modifying, by the database manager, the local copy of the document to include a location information of the remote copy.

Abstract: Methods, systems, and devices for cache metadata management in a memory subsystem are described. The memory subsystem may include an interface controller coupled with a non-volatile memory and a volatile memory. The interface controller may use metadata, such as validity information and dirty information, to operate the volatile memory as cache. The interface controller may store the dirty information in the volatile memory and may store the validity information in an array in the interface controller.

Abstract: A cooking appliance and methods for operating the same in a crisp reheat cycle are provided. In one example aspect, the cooking appliance includes features for crisp reheating a food item that has been cooked and chilled thereafter. The cooking appliance includes a casing defining a cooking cavity configured to receive food items. The cooking appliance also includes a controller. The controller can access data that provides a plurality of crisp reheating instructions for operating the cooking appliance in a crisp reheat cycle for various food items. The controller retrieves a crisp reheating instruction associated with a food type selected by a user. The controller then commences the crisp reheat cycle by activating heating elements of the cooking appliance, such as a microwave module, an upper heater module, a lower heater module, and a convection module.

Abstract: A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor.