Abstract: An electronically controlled capsule or medicament delivery system (900) is provided. Disposed within a housing (102) of the system (900) configured for internal placement within a patient is a reservoir (960) for storing medicament. The reservoir (960) communicates with at least one respective aperture (970) of the housing (102). A pressure mechanism (962) is provided for displacing medicament stored within the reservoir (960) for causing the medicament to exit the housing (102) through the at least one respective aperture (970). At least one a closure member (966) is provided. Respective closure members (966) are in fluid communication with an associated aperture. The respective closure members (966) are actuatable between a closed state for substantially blocking flow of the medicament through the respective closure member (966) and an open state for permitting flow of the medicament through the respective closure member (966) for dispensing of the medicament.

Abstract: A treatment system (1600, 1900) is provided for traversing the alimentary tract. The system (1600, 1900) includes an ingestible capsule, which includes a gas pressurizing module (1602)) providing a gas and at least one balloon (1604, 1901) in fluid communication with the gas pressurization module (1602). The capsule further includes an exhaust channel (1610) in fluid communication with a respective balloon of the at least one balloon (1604, 1901), and a depressurizing closure member (1608) for selectively controlling flow of gas between the balloon (1604, 1901) and the ambient surroundings of the capsule. The system further includes control circuitry (906) for controlling the depressurizing closure member (1608).

Abstract: An ingestible electrical capsule system (1400) for acquiring samples along the alimentary tract of a patient is provided. The capsule system (1400) includes a housing (102) having at least one aperture (970); at least one impervious collection chamber (1402) disposed within the housing (102) and having at least one aperture in fluid communication with a respective aperture of the housing (102); and at least one closure member (966). Individual closure members (966) are associated with a respective aperture of the at least one collection chamber (1402), wherein the individual closure members (966) are actuatable between an open state for permitting flow of the fluid through the respective closure member into the associated collection chamber (1402) for acquiring a sample of ambient fluid, and a closed state for substantially blocking flow of fluid into and out of the associated collection chamber (1402) for storing the acquired sample.