Patents by Inventor Judy Y. Chang

Judy Y. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for refolding insoluble, misfolded insulin-like growth factor-1 into an active conformation
    Patent number: 5410026
    Abstract: A method for refolding insoluble, improperly folded IGF-I is provided, wherein the IGF-I, precipitated from prokaryotic host cells, is concurrently solubilized, unfolded, and refolded into a biologically active conformation in a single buffer. The buffer contains reducing agent and chaotropic agent to solubilize the IGF-I at concentrations sufficiently low to allow solubilization and refolding to occur. Also provided is a triple-protease deficient E. coli host suitable for use in the process.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: April 25, 1995
    Assignee: Genentech, Inc.
    Inventors: Judy Y. Chang, Nancy C. McFarland, James R. Swartz
  • Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
    Patent number: 5288931
    Abstract: A method for refolding insoluble, improperly folded IGF-I is provided, wherein the IGF-I, precipitated from prokaryotic host cells, it concurrently solubilized, unfolded, and refolded into a biologically active conformation in a single buffer. The buffer contains reducing agent and chaotropic agent to solubilize the IGF-I at concentrations sufficiently low to allow solubilization and folding to occur. Also provided is a triple-protease deficient E. coli host suitable for use in the process.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: February 22, 1994
    Assignee: Genentech, Inc.
    Inventors: Judy Y. Chang, Nancy C. McFarland, James R. Swartz