Patents by Inventor Jue-Yeon Lee

Jue-Yeon Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140377243
    Abstract: The present invention relates to a cell permeable fusion protein for strengthening regenerative potential of stem cells, and more particularly to a cell permeable fusion protein for strengthening regenerative potential of stem cells for stimulating the differentiation of stem cells, inhibiting apoptosis, maintaining the functionality of stem cells and restoring the stress-inhibited functionality of stem cells.
    Type: Application
    Filed: December 16, 2011
    Publication date: December 25, 2014
    Applicants: NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO, LTD., SEOUL NATIONAL UNIVERSITY R AND DB FOUNDATION
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20140336067
    Abstract: The present invention relates to a method for discovering bioactive peptides, and a use thereof. The present invention relates to a method for discovering a peptide which has an effect on tissue regeneration or a peptide which adheres to a biomaterial, by searching the smallest bioactive domain from a protein. This method for discovering a peptide is named PEPscovery (PEPtide Discovery). According to the present invention, it is possible to discover peptides comprising 20 or more amino acids more rapidly than conventional techniques for discovering a peptide, and to discover bioactive peptides effective in tissue regeneration and capable of being adhered to a specific biomaterial through PEPscovery, thereby developing medical supplies and medical equipment and applying the same to the development of a diagnostic chip.
    Type: Application
    Filed: December 13, 2012
    Publication date: November 13, 2014
    Applicant: Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
    Inventors: Chong-Pyoung Chung, Yoon Jeong Park, Jue-Yeon Lee
  • Patent number: 8853165
    Abstract: The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: October 7, 2014
    Assignee: Nano Intelligent Biomedical Engineering Corporation Co., Ltd.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Sang Hoon Rhee, Jue-Yeon Lee
  • Publication number: 20140187743
    Abstract: The present invention relates to a membrane having bound thereto an antibacterial peptide that binds to collagen, and more particularly to a collagen membrane comprising a fusion peptide of a collagen-binding peptide and an antibacterial peptide, fixed to the collagen surface. The present invention provides a collagen membrane having surface activity by a fusion peptide bound to the surface thereof. When the collagen membrane is transplanted in vivo, the retention time of the fusion peptide in a local region can increase, and the fusion peptide can promote the cell migration, proliferation and differentiation associated with bone tissue regeneration, thereby maximizing the ability to regenerate bone tissue. Thus, the collagen membrane contributes to the development of therapeutic technology for bone induction and regeneration. Also, the fusion peptide may be applied to other types of graft materials made of collagen.
    Type: Application
    Filed: December 16, 2011
    Publication date: July 3, 2014
    Applicant: Nano Intelligent Biomedical Engineering Corporation Co., Ltd.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee, In Kyong Shim, Hyun Jung Park
  • Patent number: 8546529
    Abstract: The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: October 1, 2013
    Assignees: Nano Intelligent Biomedical Engineering Corporation Co., Ltd., Seoul National University Industry Foundation
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20130237484
    Abstract: The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immuno-genicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development of a drug delivery system and treatment technologies using said peptide.
    Type: Application
    Filed: April 25, 2011
    Publication date: September 12, 2013
    Applicants: Nanao Intelligent Biomedical Engineering Corporation Co., Ltd., Seoul National University R&DB Foundation
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee, Jin Sook Suh
  • Publication number: 20130224128
    Abstract: The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.
    Type: Application
    Filed: February 28, 2011
    Publication date: August 29, 2013
    Applicant: NANO INTELLIGENT BIOMEDICAL ENGINEERING CO., LTD.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20130210707
    Abstract: The present invention relates to a peptide having antibacterial or anti-inflammatory activity and a pharmaceutical composition containing the same as an active ingredient, and more particularly to a peptide having antibacterial or anti-inflammatory activity against dental bacteria, including periodontal pathogens, and bacteria causing atopic dermatitis, and to a pharmaceutical composition containing the peptide as an active ingredient. The inventive peptide having antibacterial or anti-inflammatory activity can be used for the treatment of both dental infectious diseases, including periodontitis or peri-implantitis, and inflammations, including atopy, psoriasis or arthritis.
    Type: Application
    Filed: June 13, 2011
    Publication date: August 15, 2013
    Applicant: Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20130210736
    Abstract: The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide.
    Type: Application
    Filed: March 9, 2011
    Publication date: August 15, 2013
    Applicant: NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Sang Hoon Rhee, Jue- Yeon Lee
  • Patent number: 8349804
    Abstract: The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: January 8, 2013
    Assignee: Seoul National University Industry Foundation
    Inventors: Yoon-Jeong Park, Chong-Pyoung Chung, Seung-Jin Lee, Jue-Yeon Lee
  • Publication number: 20110213036
    Abstract: The present invention relates to a composition for prevention of tooth hypersensitivity, and more particularly to a composition for prevention of tooth hypersensitivity, which comprises an adhesive polymer for coating teeth, an active ingredient for prevention of hypersensitivity, a substance for promoting the penetration of the active ingredient for prevention of hypersensitivity, a desensitizing active ingredient, and a pH-adjusting agent. The composition for prevention of tooth hypersensitivity according to the invention can rapidly show the effect of preventing tooth hypersensitivity while maintaining the sensory feel of conventional tooth desensitizers, and it can maintain the tooth hypersensitivity-preventing effect for a long time.
    Type: Application
    Filed: October 8, 2009
    Publication date: September 1, 2011
    Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
    Inventors: Yoon-Jeong Park, Chong-Pyoung Chung, Jue-Yeon Lee, Hyun Jung Park
  • Publication number: 20110045048
    Abstract: The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide.
    Type: Application
    Filed: January 19, 2007
    Publication date: February 24, 2011
    Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
    Inventors: Yoon-Jeong Park, Chong-Pyoung Chung, Seung-Jin Lee, Jue-Yeon Lee
  • Publication number: 20100317587
    Abstract: The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc.
    Type: Application
    Filed: June 5, 2008
    Publication date: December 16, 2010
    Applicants: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION, NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20100104519
    Abstract: The present invention relates to a tooth whitening agent delivery system, more particularly, to a tooth whitening composition comprising an adhesive polymer, a tooth whitening active material, a material for promoting penetration of the tooth whitening active material, a hydrophobic surfactant, a stabilizer, an antioxidant, an antihypersensitive agent, pyrophosphate and SiO2.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 29, 2010
    Applicant: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee, Hyun Jung Park