Abstract: An injection device for administering a substance, including a housing, a plunger rod which can be moved relative to the housing, at least one retaining element associated with the rod to hold the rod relative to the housing, and a displaceable locking sleeve which can be displaced relative to the housing from one position in which the sleeve holds the at least one retaining element in a retaining position to a second position in which the at least one retaining element is released.

Abstract: An autoinjector for dispensing a liquid product includes a housing; a product container arranged in the housing, particularly, a syringe comprising a displaceable piston; a drive member; a first spring which acts on the drive member and the piston to dispense the product from the container; signal element releasably axially coupled with the drive member so that the signal element is transported in the dispensing direction as the drive member is displaced; and a second spring, which exerts a spring force on the signal element against the dispensing direction and is tensioned as the signal element is transported in the dispensing direction. When the signal element is released or detached from the axial coupling, the second spring causes the signal element to accelerate opposite the dispensing direction and strike against a signal stop and generate an acoustic and/or tactile signal.

Abstract: A method for analyzing a patient based on a volumetric pulmonary scan includes receiving volumetric pulmonary scan data representative of a patient's pulmonary structure. This method also includes determining a level of transpulmonary pressure defining an effort metric based on one or more characteristics from the received volumetric pulmonary scan data. This method further includes determining one or more physiological or anatomical parameters associated with the transpulmonary pressure based on the received volumetric pulmonary scan data and the effort metric. A non-transitory computer readable medium can be programmed with instructions for causing one or more processors to perform the method for analyzing a patient based on a volumetric pulmonary scan.

Abstract: A method for visualizing a tubular object from a set of volumetric data may include the steps of: determining a viewing direction for the tubular object; selecting a constraint subset of the tubular object within the volumetric data; defining a cut-surface through the volumetric data and including the constraint subset of the tubular object within the volumetric data; and rendering an image based upon the determined viewing direction and the volumetric data of the tubular object along the intersection of the volumetric data and the defined cut-surface. Additionally or alternatively, the method may identify a plurality of bifurcations in the tubular object; assign a weighting factor to each identified bifurcation; determine a bifurcation normal vector associated with each bifurcation; determine a weighted average of the bifurcation normal vectors; and render an image of the volumetric data from a perspective parallel to the weighted average of the bifurcation normal vectors.

Abstract: A method for visualizing a tubular object from a set of volumetric data may include the steps of: determining a viewing direction for the tubular object; selecting a constraint subset of the tubular object within the volumetric data; defining a cut-surface through the volumetric data and including the constraint subset of the tubular object within the volumetric data; and rendering an image based upon the determined viewing direction and the volumetric data of the tubular object along the intersection of the volumetric data and the defined cut-surface. Additionally or alternatively, the method may identify a plurality of bifurcations in the tubular object; assign a weighting factor to each identified bifurcation; determine a bifurcation normal vector associated with each bifurcation; determine a weighted average of the bifurcation normal vectors; and render an image of the volumetric data from a perspective parallel to the weighted average of the bifurcation normal vectors.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: A system and method for navigating a medical instrument in a branched structure of a body employs a tracking system, for collecting positional information for the medical instrument, and data, which defines a geometrical model of the branched structure, in particular, coordinates for predetermined points defining a pathway extending along branches of the model. Coordinates are identified for each Euclidean distance of the instrument, from an anchor point of a coordinate system for the tracking system, that corresponds to a Euclidean distance of a designated point, of the predetermined points, from a reference point of a coordinate system for the model, wherein the anchor point of the tracking coordinate system has been established to correspond to the reference point of the model coordinate system. The two coordinate systems are registered to one another using the identified coordinates of the instrument and the corresponding coordinates of each designated point.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: A system and method for navigating a medical instrument in a branched structure of a body employs a tracking system, for collecting positional information for the medical instrument, and data, which defines a geometrical model of the branched structure, in particular, coordinates for predetermined points defining a pathway extending along branches of the model. Coordinates are identified for each Euclidean distance of the instrument, from an anchor point of a coordinate system for the tracking system, that corresponds to a Euclidean distance of a designated point, of the predetermined points, from a reference point of a coordinate system for the model, wherein the anchor point of the tracking coordinate system has been established to correspond to the reference point of the model coordinate system. The two coordinate systems are registered to one another via a mathematical transformation using the identified coordinates of the instrument and the corresponding coordinates of each designated point.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: Methods and systems for displaying a volumetric model of a patient's lung including sublobar regions. The system may include a processor and software operable on the processor to receive data from multi-dimensional images of the patient's lungs, such as CT images, and produce data for creation of a volumetric model of the patient's lungs, including sublobar regions, on a graphical user interface. The system may also display the multi-dimensional images on the graphical user interface. A user may select an airway location in the airways on the volumetric model or a multi-dimensional image on the graphical user interface and the portion of the lung distal to the selected location, which may be a sublobe, may be highlighted and/or characterized by the system.

Abstract: A system and method for navigating a medical instrument in a branched structure of a body employs a tracking system, for collecting positional information for the medical instrument, and data, which defines a geometrical model of the branched structure, in particular, coordinates for predetermined points defining a pathway extending along branches of the model. Coordinates are identified for each Euclidean distance of the instrument, from an anchor point of a coordinate system for the tracking system, that corresponds to a Euclidean distance of a designated point, of the predetermined points, from a reference point of a coordinate system for the model, wherein the anchor point of the tracking coordinate system has been established to correspond to the reference point of the model coordinate system. The two coordinate systems are registered to one another using the identified coordinates of the instrument and the corresponding coordinates of each designated point.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.

Abstract: A system and method for navigating a medical instrument in a branched structure of a body employs a tracking system, for collecting positional information for the medical instrument, and data, which defines a geometrical model of the branched structure, in particular, coordinates for predetermined points defining a pathway extending along branches of the model. Coordinates are identified for each Euclidean distance of the instrument, from an anchor point of a coordinate system for the tracking system, that corresponds to a Euclidean distance of a designated point, of the predetermined points, from a reference point of a coordinate system for the model, wherein the anchor point of the tracking coordinate system has been established to correspond to the reference point of the model coordinate system. The two coordinate systems are registered to one another via a mathematical transformation using the identified coordinates of the instrument and the corresponding coordinates of each designated point.

Abstract: Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one or more locations within the portion that are therapeutically linked to the target treatment region. Other treatment planning methods, devices and systems are included.

Abstract: Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.