Abstract: An orally administered preparation with controlled lease of an opioid analgesic in the form of crystals having particle size of 10 &mgr;m to 3 mm, preferably of 50 &mgr;m to 1 mm, which have at least one controlled release coating.

Abstract: Pharmaceutical formulations containing an opioid, an &agr;-agonist and/or their physically compatible salts, from which at least one medicinally active ingredient is released in a sustained manner.

Abstract: Solid medicinal forms having a multiphase structure for oral administration, containing gatifloxacin or pharmaceutically acceptable salts or hydrates thereof and auxiliary substances selected from the group of fillers, binders, lubricants, disintegration aids and mixtures thereof, in which the inner phase contains the active ingredient gatifloxacin or pharmaceutically acceptable salts or hydrates thereof and auxiliary substances from the group of binders, fillers, disintegration aids and mixtures thereof, and at least one outer phase necessarily contains at least one disintegration aid and further auxiliary substances from the group of at least one lubricant, optionally fillers and/or optionally binders, and a process for the preparation of such solid medicinal forms.

Abstract: Rapidly disintegrating, binder-free tablets of tramadol or a tramadol salt for oral administration comprising microcrystalline cellulose and tramadol or a pharmaceutically acceptable tramadol salt in a weight ratio of at least 2:1.

Abstract: The invention relates to polysaccharides which are crosslinked with bifunctional crosslinkers and are no longer water-soluble but are still biodegradable, have a swelling of from 100 to 1000%, where the swelling, which means the percentage gain in weight, is determined by the following equation: ##EQU1## in which A is the percentage gain in weight, W.sub.o is the weight of the dry polymer and W.sub.t is the weight of the swollen polymer saturated with water. It likewise relates to a process for preparing the crosslinked polysaccharides and to the use of the crosslinked polysaccharides for coating and/or embedding medicinal active substances or drug compositions. The invention furthermore relates to a drug which contains an active substance which acts in the large intestine or an active substance which is broken down on passing through the stomach or small intestine, coated with or embedded in one of the crosslinked polysaccharides.