Abstract: A device supplies energy to a sensor arrangement in a rail vehicle. The device has a housing in which there is arranged a coil which can be inductively coupled to a motor cable carrying an alternating current. The housing is embodied to enclose part of a length of the motor cable, and the coil is wound around an annular coil core which concentrically or substantially concentrically surrounds the motor cable. The housing has multiple parts including at least one first and one second housing part. The annular coil core is implemented in multiple parts and a first coil core part is arranged in the first housing part and a second coil core part is arranged in the second housing part. The housing is further embodied to mechanically secure the motor cable to a component of the rail vehicle and/or to mechanically connect the motor cable to a further motor cable.

Abstract: The present invention relates to antigen binding sites, compositions and uses thereof in the treatment of conditions associated with pathogenic proteins. In one example the condition is Alzheimer's disease.

Abstract: A device supplies energy to a sensor arrangement in a rail vehicle. The device has a housing in which there is arranged a coil which can be inductively coupled to a motor cable carrying an alternating current. The housing is embodied to enclose part of a length of the motor cable, and the coil is wound around an annular coil core which concentrically or substantially concentrically surrounds the motor cable. The housing has multiple parts including at least one first and one second housing part. The annular coil core is implemented in multiple parts and a first coil core part is arranged in the first housing part and a second coil core part is arranged in the second housing part. The housing is further embodied to mechanically secure the motor cable to a component of the rail vehicle and/or to mechanically connect the motor cable to a further motor cable.

Abstract: The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.

Abstract: The present invention relates to methods of restoring cognitive function in aged individuals that do not exhibit a clinically detectable neurodegenerative disease. In one aspect, the present invention provides a method of improving cognitive function in an aged individual that does not have a neurodegenerative disease characterized by aggregation of a pathological protein, the method comprising or consisting of: applying a clinically safe level of acoustic energy to sites within a region of the brain, thereby saturating or substantially saturating the region with acoustic energy, thereby improving cognitive function in the aged individual.

Abstract: The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.

Abstract: The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.

Abstract: The invention relates to an assay for identifying compounds for the treatment of various diseases including those associated with excitotoxicity. The invention also relates to cell lines and constructs for use in an assay of the invention. The invention also relates to methods for determining whether a compound reduces excitotoxic signalling in a cell and whether a compound that inhibits binding of Tau to Fyn is likely to selectively reduce excitotoxic cell signalling. The invention also relates to a Tau protein adapted to form a detectable signal when the Tau protein is bound to a Fyn protein. The invention also relates to a Fyn protein adapted to form a detectable signal when the Fyn protein is bound to a Tau protein.

Abstract: The invention relates to a device (1) for applying liquid coating materials, particularly paints, onto an application surface (8), comprising an ejection system (11) for the coating material, wherein the coating material is fed to a displacement chamber (12), is applied in the displacement chamber (12) by means of a displacement element (13), is fed from the displacement chamber (12) to a throttle (26) in metered doses and is then forcefully ejected via the throttle opening (5) thereof against the application surface (8) in the form of droplets.

Abstract: The invention relates to the distribution of printer paper via a housing flap of a printer, the housing flap being rotatably mounted about an axle by use of a hinge, and at least one central part of the hinge may be a printing paper opening having at least a width B.

Abstract: A housing is disclosed which may be used for a tachograph. The housing includes a battery holder and at least one fastening element arranged to fasten the battery holder to the housing. With the housing it is possible to mount a battery in an exchangeable manner while preventing the possibility of manipulating the components inside the housing during a changing of the battery. When the battery holder is mounted on the housing, the fastening element can only be accessed from the inside of the housing.

Abstract: The invention relates to a lead seal which is introduced into an opening, having a projection, which shaves off when there is a continued insertion movement, the base body being provided with a hook which can be latched opposite the plane enclosed by the limiting contour of the opening to be sealed. In addition, an arrangement having a housing which can be joined together and having an opening to be sealed by the lead seal is the subject matter of the invention, the lead seal having a base body which is provided with a shaped section which limits, in an interlocking manner, the ability of the lead seal to move in the insertion direction. Such lead seals or arrangements have until now been deficient in terms of the intended evidence function. In this case, the invention provides a remedy by the lead seal being fixed to the second housing part opposite the plane enclosed by the limiting contour of the opening to be sealed. In addition, the hook may be in the form of a snap hook.

Abstract: The invention relates to the distribution of printer paper via a housing flap of a printer, the housing flap being rotatably mounted about an axle by use of a hinge, and at least one central part of the hinge may be a printing paper opening having at least a width B.

Abstract: For the distribution of printer paper via a housing flap of a printer, the housing flap is rotatably mounted about an axle by use of a hinge. At least one central part of the hinge may be a printing paper opening having at least a width B.

Abstract: A housing is disclosed which may be used for a tachograph. The housing includes a battery holder and at least one fastening element arranged to fasten the battery holder to the housing. With the housing it is possible to mount a battery in an exchangeable manner while preventing the possibility of manipulating the components inside the housing during a changing of the battery. When the battery holder is mounted on the housing, the fastening element can only be accessed from the inside of the housing.

Abstract: A device is described for applying a fluid medium to a substrate, having a capillary tube or a needle having one end, a first means using which the exit of the fluid medium from the end of the capillary tube or the adherence of the fluid medium to the end of the needle, in particular in the form of a droplet is detectable, and having further means using which the distance of the end of the capillary tube or the needle to the substrate can be changed. Furthermore, an image recording device and an image processing device associated therewith are provided, using which the point in time of the transfer of a droplet, located at the end of the capillary tube or the needle, from the capillary tube or the needle to the substrate is detectable when the distance of the end of the capillary tube or the needle to the substrate diminishes.

Abstract: The invention relates to a lead seal (3) which is introduced into an opening (2), having a projection (13), which shaves off when there is a continued insertion movement, the base body (15) being provided with a hook (31) which can be latched opposite the plane enclosed by the limiting contour of the opening (2) to be sealed. In addition, an arrangement having a housing which can be joined together and having an opening (2) to be sealed by means of the lead seal (3) is the subject matter of the invention, the lead seal (3) having a base body (15) which is provided with a shaped section which limits, in an interlocking manner, the ability of the lead seal to move in the insertion direction. Such lead seals or arrangements have until now been deficient in terms of the intended evidence function. In this case, the invention provides a remedy by the lead seal (3) being fixed to the second housing part (9) opposite the plane enclosed by the limiting contour of the opening (2) to be sealed.

Abstract: The present invention relates to a navigational button including an actuating element which is displaceable at least in two directions and controls the navigation button. The present actuating element is arranged in a casing and performs an action on a communication element. A limitation element is disposed between the actuating element and the casing in such a way that it limits actuation efforts performed on the navigational button.